Buchumschlag

Hoxa9 and Meis1 cooperatively induce addiction to syk signaling by suppressing miR-146a in acute myeloid leukemia

The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene overexpression but is currently considered undruggable. We therefore investigated whether myeloid progenitor cells transformed by Hoxa9 and Meis1 become addicted to targetable signaling pathways. A comprehensive...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Mohr, Sebastian (VerfasserIn) , Doebele, Carmen (VerfasserIn) , Comoglio, Federico (VerfasserIn) , Berg, Tobias (VerfasserIn) , Beck, Julia (VerfasserIn) , Bohnenberger, Hanibal (VerfasserIn) , Alexe, Gabriela (VerfasserIn) , Corso, Jasmin (VerfasserIn) , Ströbel, Philipp (VerfasserIn) , Wachter, Astrid (VerfasserIn) , Beißbarth, Tim (VerfasserIn) , Schnütgen, Frank (VerfasserIn) , Cremer, Anjali (VerfasserIn) , Haetscher, Nadine (VerfasserIn) , Göllner, Stefanie (VerfasserIn) , Rouhi, Arefeh (VerfasserIn) , Palmqvist, Lars (VerfasserIn) , Rieger, Michael A. (VerfasserIn) , Schroeder, Timm (VerfasserIn) , Bönig, Halvard (VerfasserIn) , Müller-Tidow, Carsten (VerfasserIn) , Kuchenbauer, Florian (VerfasserIn) , Schütz, Ekkehard (VerfasserIn) , Green, Anthony R. (VerfasserIn) , Urlaub, Henning (VerfasserIn) , Stegmaier, Kimberly (VerfasserIn) , Humphries, R. Keith (VerfasserIn) , Serve, Hubert (VerfasserIn) , Oellerich, Thomas (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 20 April 2017
In: Cancer cell
Year: 2017, Jahrgang: 31, Heft: 4, Pages: 549-562, e1-e11
ISSN:1878-3686
DOI:10.1016/j.ccell.2017.03.001
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.ccell.2017.03.001
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1535610817300636
Verlag, Volltext: https://www.sciencedirect.com/science/article/pii/S1535610817300636?via%3Dihub
Resolving-System, Volltext: https://dx.doi.org/10.1016/j.ccell.2017.03.001
Volltext
Verfasserangaben:Sebastian Mohr, Carmen Doebele, Federico Comoglio, Tobias Berg, Julia Beck, Hanibal Bohnenberger, Gabriela Alexe, Jasmin Corso, Philipp Ströbel, Astrid Wachter, Tim Beissbarth, Frank Schnütgen, Anjali Cremer, Nadine Haetscher, Stefanie Göllner, Arefeh Rouhi, Lars Palmqvist, Michael A. Rieger, Timm Schroeder, Halvard Bönig, Carsten Müller-Tidow, Florian Kuchenbauer, Ekkehard Schütz, Anthony R. Green, Henning Urlaub, Kimberly Stegmaier, R. Keith Humphries, Hubert Serve, and Thomas Oellerich

MARC

LEADER 00000caa a2200000 c 4500
001 101912279X
003 DE-627
005 20241126110017.0
007 cr uuu---uuuuu
008 180418s2017 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.ccell.2017.03.001  |2 doi 
035 |a (DE-627)101912279X 
035 |a (DE-599)GBV101912279X 
035 |a (OCoLC)1340370588 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Mohr, Sebastian  |d 1972-  |e VerfasserIn  |0 (DE-588)124507131  |0 (DE-627)575605383  |0 (DE-576)294205071  |4 aut 
245 1 0 |a Hoxa9 and Meis1 cooperatively induce addiction to syk signaling by suppressing miR-146a in acute myeloid leukemia  |c Sebastian Mohr, Carmen Doebele, Federico Comoglio, Tobias Berg, Julia Beck, Hanibal Bohnenberger, Gabriela Alexe, Jasmin Corso, Philipp Ströbel, Astrid Wachter, Tim Beissbarth, Frank Schnütgen, Anjali Cremer, Nadine Haetscher, Stefanie Göllner, Arefeh Rouhi, Lars Palmqvist, Michael A. Rieger, Timm Schroeder, Halvard Bönig, Carsten Müller-Tidow, Florian Kuchenbauer, Ekkehard Schütz, Anthony R. Green, Henning Urlaub, Kimberly Stegmaier, R. Keith Humphries, Hubert Serve, and Thomas Oellerich 
264 1 |c 20 April 2017 
300 |b Illustrationen 
300 |a 25 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Erscheinungsdatum im PDF: April 10, 2017 
500 |a Gesehen am 26.11.2024 
520 |a The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene overexpression but is currently considered undruggable. We therefore investigated whether myeloid progenitor cells transformed by Hoxa9 and Meis1 become addicted to targetable signaling pathways. A comprehensive (phospho)proteomic analysis revealed that Meis1 increased Syk protein expression and activity. Syk upregulation occurs through a Meis1-dependent feedback loop. By dissecting this loop, we show that Syk is a direct target of miR-146a, whose expression is indirectly regulated by Meis1 through the transcription factor PU.1. In the context of Hoxa9 overexpression, Syk signaling induces Meis1, recapitulating several leukemogenic features of Hoxa9/Meis1-driven leukemia. Finally, Syk inhibition disrupts the identified regulatory loop, prolonging survival of mice with Hoxa9/Meis1-driven leukemia. Hox genes; PU.1; Syk; leukemia; microRNA; signal transduction 
650 4 |a Hox genes 
650 4 |a leukemia 
650 4 |a microRNA 
650 4 |a PU.1 
650 4 |a signal transduction 
650 4 |a Syk 
700 1 |a Doebele, Carmen  |e VerfasserIn  |4 aut 
700 1 |a Comoglio, Federico  |e VerfasserIn  |4 aut 
700 1 |a Berg, Tobias  |e VerfasserIn  |4 aut 
700 1 |a Beck, Julia  |e VerfasserIn  |4 aut 
700 1 |a Bohnenberger, Hanibal  |e VerfasserIn  |4 aut 
700 1 |a Alexe, Gabriela  |e VerfasserIn  |4 aut 
700 1 |a Corso, Jasmin  |e VerfasserIn  |4 aut 
700 1 |a Ströbel, Philipp  |d 1969-  |e VerfasserIn  |0 (DE-588)115588272  |0 (DE-627)077346734  |0 (DE-576)289964784  |4 aut 
700 1 |a Wachter, Astrid  |e VerfasserIn  |4 aut 
700 1 |a Beißbarth, Tim  |e VerfasserIn  |0 (DE-588)1262259185  |0 (DE-627)1809706106  |4 aut 
700 1 |a Schnütgen, Frank  |e VerfasserIn  |4 aut 
700 1 |a Cremer, Anjali  |e VerfasserIn  |4 aut 
700 1 |a Haetscher, Nadine  |e VerfasserIn  |4 aut 
700 1 |a Göllner, Stefanie  |d 1979-  |e VerfasserIn  |0 (DE-588)133882764  |0 (DE-627)557870151  |0 (DE-576)300169191  |4 aut 
700 1 |a Rouhi, Arefeh  |e VerfasserIn  |4 aut 
700 1 |a Palmqvist, Lars  |e VerfasserIn  |4 aut 
700 1 |a Rieger, Michael A.  |d 1976-  |e VerfasserIn  |0 (DE-588)1146567502  |0 (DE-627)1008046612  |0 (DE-576)188249923  |4 aut 
700 1 |a Schroeder, Timm  |e VerfasserIn  |4 aut 
700 1 |8 1\p  |a Bönig, Halvard  |d 1967-  |e VerfasserIn  |0 (DE-588)120496100  |0 (DE-627)696726009  |0 (DE-576)29224973X  |4 aut 
700 1 |a Müller-Tidow, Carsten  |d 1968-  |e VerfasserIn  |0 (DE-588)1015101798  |0 (DE-627)705330230  |0 (DE-576)351197893  |4 aut 
700 1 |a Kuchenbauer, Florian  |d 1974-  |e VerfasserIn  |0 (DE-588)123986974  |0 (DE-627)085567167  |0 (DE-576)293970823  |4 aut 
700 1 |a Schütz, Ekkehard  |e VerfasserIn  |4 aut 
700 1 |a Green, Anthony R.  |e VerfasserIn  |4 aut 
700 1 |a Urlaub, Henning  |e VerfasserIn  |4 aut 
700 1 |a Stegmaier, Kimberly  |e VerfasserIn  |4 aut 
700 1 |a Humphries, R. Keith  |e VerfasserIn  |4 aut 
700 1 |a Serve, Hubert  |e VerfasserIn  |0 (DE-588)1169095399  |0 (DE-627)1032734256  |0 (DE-576)511922388  |4 aut 
700 1 |a Oellerich, Thomas  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Cancer cell  |d Cambridge, Mass. : Cell Press, 2002  |g 31(2017), 4 vom: Apr., Seite 549-562, e1-e11  |h Online-Ressource  |w (DE-627)343970082  |w (DE-600)2074034-7  |w (DE-576)097935972  |x 1878-3686  |7 nnas  |a Hoxa9 and Meis1 cooperatively induce addiction to syk signaling by suppressing miR-146a in acute myeloid leukemia 
773 1 8 |g volume:31  |g year:2017  |g number:4  |g month:04  |g pages:549-562, e1-e11  |g extent:25  |a Hoxa9 and Meis1 cooperatively induce addiction to syk signaling by suppressing miR-146a in acute myeloid leukemia 
856 4 0 |u https://doi.org/10.1016/j.ccell.2017.03.001  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S1535610817300636  |x Verlag  |z kostenfrei  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S1535610817300636?via%3Dihub  |x Verlag  |3 Volltext 
856 4 0 |u https://dx.doi.org/10.1016/j.ccell.2017.03.001  |x Resolving-System  |3 Volltext 
883 |8 1\p  |a cgwrk  |d 20241001  |q DE-101  |u https://d-nb.info/provenance/plan#cgwrk 
951 |a AR 
992 |a 20200302 
993 |a Article 
994 |a 2017 
998 |g 1015101798  |a Müller-Tidow, Carsten  |m 1015101798:Müller-Tidow, Carsten  |d 910000  |d 910100  |e 910000PM1015101798  |e 910100PM1015101798  |k 0/910000/  |k 1/910000/910100/  |p 21 
998 |g 133882764  |a Göllner, Stefanie  |m 133882764:Göllner, Stefanie  |d 910000  |d 910100  |e 910000PG133882764  |e 910100PG133882764  |k 0/910000/  |k 1/910000/910100/  |p 15 
999 |a KXP-PPN101912279X  |e 360153570X 
BIB |a Y 
SER |a journal 
JSO |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.1016/j.ccell.2017.03.001"],"eki":["101912279X"]},"physDesc":[{"noteIll":"Illustrationen","extent":"25 S."}],"relHost":[{"type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["1.2002 -"],"language":["eng"],"disp":"Hoxa9 and Meis1 cooperatively induce addiction to syk signaling by suppressing miR-146a in acute myeloid leukemiaCancer cell","recId":"343970082","note":["Gesehen am 28.02.11"],"physDesc":[{"extent":"Online-Ressource"}],"part":{"pages":"549-562, e1-e11","year":"2017","volume":"31","text":"31(2017), 4 vom: Apr., Seite 549-562, e1-e11","issue":"4","extent":"25"},"id":{"eki":["343970082"],"issn":["1878-3686"],"zdb":["2074034-7"]},"title":[{"title":"Cancer cell","title_sort":"Cancer cell"}],"origin":[{"dateIssuedDisp":"2002-","publisher":"Cell Press ; Elsevier","publisherPlace":"Cambridge, Mass. ; New York, NY","dateIssuedKey":"2002"}]}],"note":["Erscheinungsdatum im PDF: April 10, 2017","Gesehen am 26.11.2024"],"recId":"101912279X","name":{"displayForm":["Sebastian Mohr, Carmen Doebele, Federico Comoglio, Tobias Berg, Julia Beck, Hanibal Bohnenberger, Gabriela Alexe, Jasmin Corso, Philipp Ströbel, Astrid Wachter, Tim Beissbarth, Frank Schnütgen, Anjali Cremer, Nadine Haetscher, Stefanie Göllner, Arefeh Rouhi, Lars Palmqvist, Michael A. Rieger, Timm Schroeder, Halvard Bönig, Carsten Müller-Tidow, Florian Kuchenbauer, Ekkehard Schütz, Anthony R. Green, Henning Urlaub, Kimberly Stegmaier, R. Keith Humphries, Hubert Serve, and Thomas Oellerich"]},"origin":[{"dateIssuedDisp":"20 April 2017","dateIssuedKey":"2017"}],"person":[{"family":"Mohr","given":"Sebastian","display":"Mohr, Sebastian","role":"aut"},{"role":"aut","family":"Doebele","display":"Doebele, Carmen","given":"Carmen"},{"role":"aut","family":"Comoglio","given":"Federico","display":"Comoglio, Federico"},{"role":"aut","family":"Berg","display":"Berg, Tobias","given":"Tobias"},{"role":"aut","given":"Julia","display":"Beck, Julia","family":"Beck"},{"display":"Bohnenberger, Hanibal","given":"Hanibal","family":"Bohnenberger","role":"aut"},{"role":"aut","display":"Alexe, Gabriela","given":"Gabriela","family":"Alexe"},{"family":"Corso","given":"Jasmin","display":"Corso, Jasmin","role":"aut"},{"role":"aut","given":"Philipp","display":"Ströbel, Philipp","family":"Ströbel"},{"family":"Wachter","display":"Wachter, Astrid","given":"Astrid","role":"aut"},{"family":"Beißbarth","given":"Tim","display":"Beißbarth, Tim","role":"aut"},{"role":"aut","display":"Schnütgen, Frank","given":"Frank","family":"Schnütgen"},{"family":"Cremer","display":"Cremer, Anjali","given":"Anjali","role":"aut"},{"family":"Haetscher","display":"Haetscher, Nadine","given":"Nadine","role":"aut"},{"family":"Göllner","given":"Stefanie","display":"Göllner, Stefanie","role":"aut"},{"given":"Arefeh","display":"Rouhi, Arefeh","family":"Rouhi","role":"aut"},{"given":"Lars","display":"Palmqvist, Lars","family":"Palmqvist","role":"aut"},{"display":"Rieger, Michael A.","given":"Michael A.","family":"Rieger","role":"aut"},{"role":"aut","family":"Schroeder","display":"Schroeder, Timm","given":"Timm"},{"role":"aut","family":"Bönig","given":"Halvard","display":"Bönig, Halvard"},{"given":"Carsten","display":"Müller-Tidow, Carsten","family":"Müller-Tidow","role":"aut"},{"role":"aut","family":"Kuchenbauer","given":"Florian","display":"Kuchenbauer, Florian"},{"role":"aut","family":"Schütz","display":"Schütz, Ekkehard","given":"Ekkehard"},{"family":"Green","display":"Green, Anthony R.","given":"Anthony R.","role":"aut"},{"role":"aut","display":"Urlaub, Henning","given":"Henning","family":"Urlaub"},{"given":"Kimberly","display":"Stegmaier, Kimberly","family":"Stegmaier","role":"aut"},{"family":"Humphries","display":"Humphries, R. Keith","given":"R. Keith","role":"aut"},{"family":"Serve","display":"Serve, Hubert","given":"Hubert","role":"aut"},{"family":"Oellerich","display":"Oellerich, Thomas","given":"Thomas","role":"aut"}],"language":["eng"],"title":[{"title":"Hoxa9 and Meis1 cooperatively induce addiction to syk signaling by suppressing miR-146a in acute myeloid leukemia","title_sort":"Hoxa9 and Meis1 cooperatively induce addiction to syk signaling by suppressing miR-146a in acute myeloid leukemia"}]} 
SRT |a MOHRSEBASTHOXA9ANDME2020 

Ähnliche Einträge