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Metastasis of prostate cancer and melanoma cells in a preclinical in vivo mouse model is enhanced by L-plastin expression and phosphorylation

Tumor cell migration and metastasis require dynamic rearrangements of the actin cytoskeleton. Interestingly, the F-actin cross-linking and stabilizing protein L-plastin, originally described as a leukocyte specific protein, is aberrantly expressed in several non-hematopoietic malignant tumors. There...

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Weitere Verfasser: Riplinger, Selina (BerichterstatterIn) , Wabnitz, Guido H. (BerichterstatterIn) , Kirchgessner, Henning (BerichterstatterIn) , Jahraus, Beate (BerichterstatterIn) , Lasitschka, Felix (BerichterstatterIn) , Schulte, Bianca (BerichterstatterIn) , Nakchbandi, Inaam (BerichterstatterIn) , Samstag, Yvonne (BerichterstatterIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2014
In: Molecular cancer
Year: 2014, Jahrgang: 13, Pages: ?
ISSN:1476-4598
DOI:10.1186/1476-4598-13-10
Online-Zugang:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/1476-4598-13-10
Volltext
Verfasserangaben:Selina M. Riplinger, Guido H. Wabnitz, Henning Kirchgessner, Beate Jahraus, Felix Lasitschka, Bianca Schulte, Gabri van der Pluijm, Geertje van der Horst, Günter J. Hämmerling, Inaam Nakchbandi, and Yvonne Samstag
Beschreibung
Zusammenfassung:Tumor cell migration and metastasis require dynamic rearrangements of the actin cytoskeleton. Interestingly, the F-actin cross-linking and stabilizing protein L-plastin, originally described as a leukocyte specific protein, is aberrantly expressed in several non-hematopoietic malignant tumors. Therefore, it has been discussed as a tumor marker. However, systematic in vivo analyses of the functional relevance of L-plastin for tumor cell metastasis were so far lacking.
Beschreibung:Gesehen am 22.08.2014
Beschreibung:Online Resource
ISSN:1476-4598
DOI:10.1186/1476-4598-13-10

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