Cover Image

Hippocampal network oscillations in APP/APLP2-deficient mice

The physiological function of amyloid precursor protein (APP) and its two homologues APP-like protein 1 (APLP1) and 2 (APLP2) is largely unknown. Previous work suggests that lack of APP or APLP2 impairs synaptic plasticity and spatial learning. There is, however, almost no data on the role of APP or...

Full description

Saved in:
Bibliographic Details
Other Authors: Zhang, Xiaomin (Other) , Weyer, Sascha W. (Other) , Both, Martin (Other) , Müller, Ulrike C. (Other) , Draguhn, Andreas (Other)
Format: Article (Journal)
Language:English
Published: April 9, 2013
In: PLOS ONE
Year: 2013, Volume: 8, Issue: 4, Pages: 1-7
ISSN:1932-6203
DOI:10.1371/journal.pone.0061198
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1371/journal.pone.0061198
Verlag, kostenfrei, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061198
Verlag, kostenfrei, Volltext: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0061198
Get full text
Author Notes: Xiaomin Zhang, Ulrike Herrmann, Sascha W. Weyer, Martin Both, Ulrike C. Müller3, Martin Korte, Andreas Draguhn

MARC

LEADER 00000caa a2200000 c 4500
001 1485348552
003 DE-627
005 20241218113435.0
007 cr uuu---uuuuu
008 141013s2013 xx |||||o 00| ||eng c
024 7 |a 10.1371/journal.pone.0061198  |2 doi 
035 |a (DE-627)1485348552 
035 |a (DE-576)415348552 
035 |a (DE-599)BSZ415348552 
035 |a (OCoLC)1340651142 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
245 0 0 |a Hippocampal network oscillations in APP/APLP2-deficient mice  |c  Xiaomin Zhang, Ulrike Herrmann, Sascha W. Weyer, Martin Both, Ulrike C. Müller3, Martin Korte, Andreas Draguhn 
264 1 |c April 9, 2013 
300 |b Illustrationen 
300 |a 7 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 18.12.2024 
520 |a The physiological function of amyloid precursor protein (APP) and its two homologues APP-like protein 1 (APLP1) and 2 (APLP2) is largely unknown. Previous work suggests that lack of APP or APLP2 impairs synaptic plasticity and spatial learning. There is, however, almost no data on the role of APP or APLP at the network level which forms a critical interface between cellular functions and behavior. We have therefore investigated memory-related synaptic and network functions in hippocampal slices from three lines of transgenic mice: APPsα-KI (mice expressing extracellular fragment of APP, corresponding to the secreted APPsα ectodomain), APLP2-KO, and combined APPsα-KI/APLP2-KO (APPsα-DM for “double mutants”). We analyzed two prominent patterns of network activity, gamma oscillations and sharp-wave ripple complexes (SPW-R). Both patterns were generally preserved in all strains. We find, however, a significantly reduced frequency of gamma oscillations in CA3 of APLP2-KO mice in comparison to APPsα-KI and WT mice. Network activity, basic synaptic transmission and short-term plasticity were unaltered in the combined mutants (APPsα-DM) which showed, however, reduced long-term potentiation (LTP). Together, our data indicate that APLP2 and the intracellular domain of APP are not essential for coherent activity patterns in the hippocampus, but have subtle effects on synaptic plasticity and fine-tuning of network oscillations. 
650 4 |a Action potentials 
650 4 |a Animal behavior 
650 4 |a Gamma spectrometry 
650 4 |a Genetic oscillators 
650 4 |a Hippocampus 
650 4 |a Mouse models 
650 4 |a Signal filtering 
650 4 |a Synaptic plasticity 
700 1 |a Zhang, Xiaomin  |0 (DE-588)1059313618  |0 (DE-627)798282223  |0 (DE-576)415306175  |4 oth 
700 1 |a Weyer, Sascha W.  |0 (DE-588)1025142209  |0 (DE-627)721246109  |0 (DE-576)369984897  |4 oth 
700 1 |a Both, Martin  |0 (DE-588)103455543X  |0 (DE-627)745844391  |0 (DE-576)382142314  |4 oth 
700 1 |a Müller, Ulrike C.  |d 1960-  |0 (DE-588)1020647965  |0 (DE-627)691291403  |0 (DE-576)361723210  |4 oth 
700 1 |a Draguhn, Andreas  |d 1961-  |0 (DE-588)121130282  |0 (DE-627)081107102  |0 (DE-576)292552394  |4 oth 
773 0 8 |i Enthalten in  |t PLOS ONE  |d San Francisco, California, US : PLOS, 2006  |g 8(2013), 4 vom: Apr., Artikel-ID e61198, Seite 1-7  |h Online-Ressource  |w (DE-627)523574592  |w (DE-600)2267670-3  |w (DE-576)281331979  |x 1932-6203  |7 nnas  |a Hippocampal network oscillations in APP/APLP2-deficient mice 
773 1 8 |g volume:8  |g year:2013  |g number:4  |g month:04  |g elocationid:e61198  |g pages:1-7  |g extent:7  |a Hippocampal network oscillations in APP/APLP2-deficient mice 
856 4 0 |u https://doi.org/10.1371/journal.pone.0061198  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061198  |x Verlag  |z kostenfrei  |3 Volltext 
856 4 0 |u http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0061198  |x Verlag  |z kostenfrei  |3 Volltext 
951 |a AR 
992 |a 20141013 
993 |a Article 
994 |a 2013 
998 |g 121130282  |a Draguhn, Andreas  |m 121130282:Draguhn, Andreas  |d 50000  |d 53200  |e 50000PD121130282  |e 53200PD121130282  |k 0/50000/  |k 1/50000/53200/  |p 7  |y j 
998 |g 1020647965  |a Müller, Ulrike C.  |m 1020647965:Müller, Ulrike C.  |d 160000  |d 160100  |e 160000PM1020647965  |e 160100PM1020647965  |k 0/160000/  |k 1/160000/160100/  |p 6 
998 |g 103455543X  |a Both, Martin  |m 103455543X:Both, Martin  |d 50000  |d 53200  |e 50000PB103455543X  |e 53200PB103455543X  |k 0/50000/  |k 1/50000/53200/  |p 5 
998 |g 1025142209  |a Weyer, Sascha W.  |m 1025142209:Weyer, Sascha W.  |d 160000  |d 160100  |e 160000PW1025142209  |e 160100PW1025142209  |k 0/160000/  |k 1/160000/160100/  |p 3 
998 |g 1059313618  |a Zhang, Xiaomin  |m 1059313618:Zhang, Xiaomin  |d 50000  |d 53200  |e 50000PZ1059313618  |e 53200PZ1059313618  |k 0/50000/  |k 1/50000/53200/  |p 1  |x j 
999 |a KXP-PPN1485348552  |e 281749914X 
BIB |a Y 
SER |a journal 
JSO |a {"origin":[{"dateIssuedKey":"2013","dateIssuedDisp":"April 9, 2013"}],"id":{"doi":["10.1371/journal.pone.0061198"],"eki":["1485348552"]},"recId":"1485348552","name":{"displayForm":[" Xiaomin Zhang, Ulrike Herrmann, Sascha W. Weyer, Martin Both, Ulrike C. Müller3, Martin Korte, Andreas Draguhn"]},"title":[{"title_sort":"Hippocampal network oscillations in APP/APLP2-deficient mice","title":"Hippocampal network oscillations in APP/APLP2-deficient mice"}],"person":[{"given":"Xiaomin","role":"oth","family":"Zhang","display":"Zhang, Xiaomin"},{"family":"Weyer","given":"Sascha W.","role":"oth","display":"Weyer, Sascha W."},{"display":"Both, Martin","role":"oth","given":"Martin","family":"Both"},{"display":"Müller, Ulrike C.","given":"Ulrike C.","role":"oth","family":"Müller"},{"family":"Draguhn","given":"Andreas","role":"oth","display":"Draguhn, Andreas"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"physDesc":[{"noteIll":"Illustrationen","extent":"7 S."}],"relHost":[{"part":{"issue":"4","year":"2013","volume":"8","pages":"1-7","extent":"7","text":"8(2013), 4 vom: Apr., Artikel-ID e61198, Seite 1-7"},"pubHistory":["1.2006 -"],"note":["Schreibweise des Titels bis 2012: PLoS ONE","Gesehen am 20.03.19"],"id":{"eki":["523574592"],"zdb":["2267670-3"],"issn":["1932-6203"]},"origin":[{"publisher":"PLOS ; PLoS","dateIssuedKey":"2006","dateIssuedDisp":"2006-","publisherPlace":"San Francisco, California, US ; Lawrence, Kan."}],"disp":"Hippocampal network oscillations in APP/APLP2-deficient micePLOS ONE","name":{"displayForm":["Public Library of Science"]},"recId":"523574592","title":[{"title":"PLOS ONE","title_sort":"PLOS ONE"}],"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"corporate":[{"display":"Public Library of Science","role":"isb"}]}],"note":["Gesehen am 18.12.2024"]} 
SRT |a HIPPOCAMPA9201 

Similar Items