The hematopoietic cytokine granulocyte-macrophage colony stimulating factor is important for cognitive functions
We recently reported expression of hematopoietic growth factor GM-CSF and its receptor (GM-CSFR) in CNS neurons. Here we evaluated this system in learning and memory formation using GM-CSF deficient mice. In complementation, GM-CSF signalling was manipulated specifically in adult murine hippocampus...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
26 September 2012
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| In: |
Scientific reports
Year: 2012, Jahrgang: 2, Pages: 1-10 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep00697 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/srep00697 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/srep00697 Verlag, kostenfrei, Volltext: http://www.nature.com/srep/2012/120926/srep00697/full/srep00697.html 
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| Verfasserangaben: | Markus Krieger, Martin Both, Simon A. Kranig, Claudia Pitzer, Matthias Klugmann, Gerhard Vogt, Andreas Draguhn & Armin Schneider |
MARC
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| 520 | |a We recently reported expression of hematopoietic growth factor GM-CSF and its receptor (GM-CSFR) in CNS neurons. Here we evaluated this system in learning and memory formation using GM-CSF deficient mice. In complementation, GM-CSF signalling was manipulated specifically in adult murine hippocampus by adeno-associated virus (AAV)-mediated GM-CSFR alpha overexpression or knock-down. GM-CSF ablation caused various hippocampus and amygdala-dependent deficits in spatial and fear memory while rendering intact basic parameters like motor function, inherent anxiety and pain threshold levels. Corroborating these data, spatial memory of AAV-injected mice was positively correlated with GM-CSFRα expression levels. Hippocampal neurons of knock-out mice showed markedly pruned dendritic trees, reduced spine densities and lower percentages of mature spines. Despite such morphological alterations, long-term potentiation (LTP) was unimpaired in the knock-out hippocampus. Collectively, these results suggest that GM-CSF signalling plays a major role in structural plasticity relevant to learning and memory. | ||
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