The choroid plexus may be an underestimated site of tumor invasion to the brain: an in vitro study using neuroblastoma cell lines
The central nervous system (CNS) is protected by several barriers, including the blood-brain (BBB) and blood-cerebrospinal fluid (BCSFB) barriers. Understanding how cancer cells circumvent these protective barriers to invade the CNS is of crucial interest, since brain metastasis during cancer is oft...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
24 October 2015
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| In: |
Cancer cell international
Year: 2015, Volume: 15 |
| ISSN: | 1475-2867 |
| DOI: | 10.1186/s12935-015-0257-2 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s12935-015-0257-2 Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12935-015-0257-2 
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| Author Notes: | Elodie Vandenhaute, Carolin Stump-Guthier, María Lasierra Losada, Tobias Tenenbaum, Henriette Rudolph, Hiroshi Ishikawa, Christian Schwerk, Horst Schroten, Matthias Dürken, Martin März and Michael Karremann |
| Summary: | The central nervous system (CNS) is protected by several barriers, including the blood-brain (BBB) and blood-cerebrospinal fluid (BCSFB) barriers. Understanding how cancer cells circumvent these protective barriers to invade the CNS is of crucial interest, since brain metastasis during cancer is often a fatal event in both children and adults. However, whereas much effort has been invested in elucidating the process of tumor cell transmigration across the BBB, the role of the BCSFB might still be underestimated considering the significant number of meningeal cancer involvement. Our work aimed to investigate the transmigration of neuroblastoma cells across the BCSFB in vitro. |
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| Item Description: | Gesehen am 22.12.2015 |
| Physical Description: | Online Resource |
| ISSN: | 1475-2867 |
| DOI: | 10.1186/s12935-015-0257-2 |