Expression screening using a Medaka cDNA library identifies evolutionarily conserved regulators of the p53/Mdm2 pathway
The p53 tumor suppressor protein is mainly regulated by alterations in the half-life of the protein, resulting in significant differences in p53 protein levels in cells. The major regulator of this process is Mdm2, which ubiquitinates p53 and targets it for proteasomal degradation. This process can...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
8 October 2015
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| In: |
BMC biotechnology
Year: 2015, Jahrgang: 15, Heft: 1 |
| ISSN: | 1472-6750 |
| DOI: | 10.1186/s12896-015-0208-y |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s12896-015-0208-y Verlag, kostenfrei, Volltext: http://bmcbiotechnol.biomedcentral.com/articles/10.1186/s12896-015-0208-y 
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| Verfasserangaben: | Ping Zhang, Anne Sophie Kratz, Mohammed Salama, Seham Elabd, Thorsten Heinrich, Joachim Wittbrodt, Christine Blattner and Gary Davidson |
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Expression screening using a Medaka cDNA library identifies evolutionarily conserved regulators of the p53/Mdm2 pathway
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