Fate restriction and multipotency in retinal stem cells

Stem cells have the capacity to both self-renew and generate postmitotic cells. Long-term tracking of individual clones in their natural environment constitutes the ultimate way to validate postembryonic stem cells. We identify retinal stem cells (RSCs) using the spatiotemporal organization of the f...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Centanin, Lázaro (VerfasserIn) , Höckendorf, Burkhard (VerfasserIn) , Wittbrodt, Joachim (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: December 1, 2011
In: Cell stem cell
Year: 2011, Jahrgang: 9, Heft: 6, Pages: 553-562
ISSN:1875-9777
DOI:10.1016/j.stem.2011.11.004
Online-Zugang:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1016/j.stem.2011.11.004
Verlag, kostenfrei, Volltext: http://www.sciencedirect.com/science/article/pii/S1934590911005327
Volltext
Verfasserangaben:Lázaro Centanin, Burkhard Hoeckendorf, and Joachim Wittbrodt

MARC

LEADER 00000caa a22000002c 4500
001 1553385810
003 DE-627
005 20240315105840.0
007 cr uuu---uuuuu
008 170213s2011 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.stem.2011.11.004  |2 doi 
035 |a (DE-627)1553385810 
035 |a (DE-576)483385816 
035 |a (DE-599)BSZ483385816 
035 |a (OCoLC)1340960120 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 32  |2 sdnb 
100 1 |a Centanin, Lázaro  |e VerfasserIn  |0 (DE-588)105927664X  |0 (DE-627)798228431  |0 (DE-576)415156548  |4 aut 
245 1 0 |a Fate restriction and multipotency in retinal stem cells  |c Lázaro Centanin, Burkhard Hoeckendorf, and Joachim Wittbrodt 
264 1 |c December 1, 2011 
300 |a 10 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 13.02.2017 
520 |a Stem cells have the capacity to both self-renew and generate postmitotic cells. Long-term tracking of individual clones in their natural environment constitutes the ultimate way to validate postembryonic stem cells. We identify retinal stem cells (RSCs) using the spatiotemporal organization of the fish retina and follow the complete offspring of a single cell during the postnatal life. RSCs generate two tissues of the adult fish retina, the neural retina (NR) and the retinal-pigmented epithelium (RPE). Despite their common embryonic origin and tight coordination during continuous organ growth, we prove that NR and RPE are maintained by dedicated RSCs that contribute in a fate-restricted manner to either one or the other tissue. We show that in the NR, RSCs are multipotent and generate all neuron types and glia. The clonal origin of these different cell types from a multipotent NSC has far-reaching implications for cell type and tissue homeostasis. 
700 1 |a Höckendorf, Burkhard  |e VerfasserIn  |0 (DE-588)1038250447  |0 (DE-627)75683273X  |0 (DE-576)392232146  |4 aut 
700 1 |a Wittbrodt, Joachim  |e VerfasserIn  |0 (DE-588)1038250919  |0 (DE-627)756835356  |0 (DE-576)167753401  |4 aut 
773 0 8 |i Enthalten in  |t Cell stem cell  |d Amsterdam [u.a.] : Elsevier, 2007  |g 9(2011), 6, Seite 553-562  |h Online-Ressource  |w (DE-627)535183836  |w (DE-600)2375356-0  |w (DE-576)267378114  |x 1875-9777  |7 nnas  |a Fate restriction and multipotency in retinal stem cells 
773 1 8 |g volume:9  |g year:2011  |g number:6  |g pages:553-562  |g extent:10  |a Fate restriction and multipotency in retinal stem cells 
856 4 0 |u http://dx.doi.org/10.1016/j.stem.2011.11.004  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u http://www.sciencedirect.com/science/article/pii/S1934590911005327  |x Verlag  |z kostenfrei  |3 Volltext 
951 |a AR 
992 |a 20170213 
993 |a Article 
994 |a 2011 
998 |g 1038250919  |a Wittbrodt, Joachim  |m 1038250919:Wittbrodt, Joachim  |d 700000  |d 721000  |e 700000PW1038250919  |e 721000PW1038250919  |k 0/700000/  |k 1/700000/721000/  |p 3  |y j 
998 |g 1038250447  |a Höckendorf, Burkhard  |m 1038250447:Höckendorf, Burkhard  |d 700000  |d 721000  |e 700000PH1038250447  |e 721000PH1038250447  |k 0/700000/  |k 1/700000/721000/  |p 2 
998 |g 105927664X  |a Centanin, Lázaro  |m 105927664X:Centanin, Lázaro  |d 700000  |d 721000  |e 700000PC105927664X  |e 721000PC105927664X  |k 0/700000/  |k 1/700000/721000/  |p 1  |x j 
999 |a KXP-PPN1553385810  |e 2953994009 
BIB |a Y 
SER |a journal 
JSO |a {"note":["Gesehen am 13.02.2017"],"title":[{"title":"Fate restriction and multipotency in retinal stem cells","title_sort":"Fate restriction and multipotency in retinal stem cells"}],"person":[{"roleDisplay":"VerfasserIn","family":"Centanin","display":"Centanin, Lázaro","given":"Lázaro","role":"aut"},{"given":"Burkhard","role":"aut","display":"Höckendorf, Burkhard","family":"Höckendorf","roleDisplay":"VerfasserIn"},{"role":"aut","given":"Joachim","display":"Wittbrodt, Joachim","family":"Wittbrodt","roleDisplay":"VerfasserIn"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"id":{"eki":["1553385810"],"doi":["10.1016/j.stem.2011.11.004"]},"physDesc":[{"extent":"10 S."}],"recId":"1553385810","name":{"displayForm":["Lázaro Centanin, Burkhard Hoeckendorf, and Joachim Wittbrodt"]},"relHost":[{"type":{"bibl":"periodical","media":"Online-Ressource"},"title":[{"title_sort":"Cell stem cell","title":"Cell stem cell"}],"note":["Gesehen am 19.09.12"],"titleAlt":[{"title":"Cell / Stem cell"}],"recId":"535183836","physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"id":{"eki":["535183836"],"zdb":["2375356-0"],"issn":["1875-9777"]},"part":{"year":"2011","text":"9(2011), 6, Seite 553-562","issue":"6","extent":"10","volume":"9","pages":"553-562"},"disp":"Fate restriction and multipotency in retinal stem cellsCell stem cell","pubHistory":["1.2007 -"],"origin":[{"publisher":"Elsevier","dateIssuedDisp":"2007-","publisherPlace":"Amsterdam [u.a.]","dateIssuedKey":"2007"}]}],"origin":[{"dateIssuedKey":"2011","dateIssuedDisp":"December 1, 2011"}]} 
SRT |a CENTANINLAFATERESTRI1201