Apoptotic-cell-derived membrane microparticles and IFN-α induce an inflammatory immune response
A Section a dysregulation in the clearance of apoptotic material is considered a major pathogenetic factor for the emergence of autoimmune diseases. Apoptotic-cell-derived membrane microparticles (AdMPs), which are released from the cell surface during apoptosis, have been implicated in the pathogen...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 July 2015
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| In: |
Journal of cell science
Year: 2015, Jahrgang: 128, Heft: 14, Pages: 2443-2453 |
| ISSN: | 1477-9137 |
| DOI: | 10.1242/jcs.162735 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1242/jcs.162735 Verlag, kostenfrei, Volltext: http://jcs.biologists.org/content/128/14/2443 
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| Verfasserangaben: | Anna Niessen, Petra Heyder, Stefan Krienke, Norbert Blank, Lars-Oliver Tykocinski, Hanns-Martin Lorenz, Martin Schiller |
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| 520 | |a A Section a dysregulation in the clearance of apoptotic material is considered a major pathogenetic factor for the emergence of autoimmune diseases. Apoptotic-cell-derived membrane microparticles (AdMPs), which are released from the cell surface during apoptosis, have been implicated in the pathogenesis of autoimmunity. Also of importance are cytokines, such as interferon-α (IFN-α), which is known to be a major player in patients with systemic lupus erythematosus (SLE). This study investigates the combined effect of AdMPs and IFN-α on professional phagocytes. In the presence of IFN-α, phagocytosis of AdMPs by human monocytes was significantly increased in a dose-dependent manner. The combination of AdMPs and raised IFN-α concentrations resulted in an increase in the secretion of pro-inflammatory cytokines and an upregulation of surface molecule expression involved in antigen uptake. In addition, macrophage polarisation was shifted towards a more inflammatory type of cell. The synergism between IFN-α and AdMPs seemed to be mediated by an upregulation of phosphorylated STAT1. Our results indicate that IFN-α, together with AdMPs, amplify the initiation and maintenance of inflammation. This mechanism might especially play a crucial role in disorders with a defective clearance of apoptotic material. | ||
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