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DNA methylation signatures in peripheral blood strongly predict all-cause mortality

DNA methylation is modulated by environmental factors and has a role in many complex diseases. Here, the authors find that methylation at specific DNA sites is associated with all-cause mortality, and a methylation-based risk score may be informative for risk assessment and stratification.

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Yan (VerfasserIn) , Breitling, Lutz Philipp (VerfasserIn) , Schöttker, Ben (VerfasserIn) , Brenner, Hermann (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 17 March 2017
In: Nature Communications
Year: 2017, Jahrgang: 8
ISSN:2041-1723
DOI:10.1038/ncomms14617
Online-Zugang:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/ncomms14617
Verlag, kostenfrei, Volltext: http://www.nature.com/ncomms/2017/170317/ncomms14617/full/ncomms14617.html
Volltext
Verfasserangaben:Yan Zhang, Rory Wilson, Jonathan Heiss, Lutz P. Breitling, Kai-Uwe Saum, Ben Schöttker, Bernd Holleczek, Melanie Waldenberger, Annette Peters & Hermann Brenner
Beschreibung
Zusammenfassung:DNA methylation is modulated by environmental factors and has a role in many complex diseases. Here, the authors find that methylation at specific DNA sites is associated with all-cause mortality, and a methylation-based risk score may be informative for risk assessment and stratification.
Beschreibung:Gesehen am 31.03.2017
Beschreibung:Online Resource
ISSN:2041-1723
DOI:10.1038/ncomms14617

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