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Comparison of gadofosveset (Vasovist®) with gadobenate dimeglumine (Multihance®)-enhanced MR angiography for high-grade carotid artery stenosis

Summary: Objective To prove superiority of blood pool contrast agent gadofosveset over conventional contrast agent gadobenate dimeglumine for assessment of stenotic internal carotid artery (ICA). Methods: Eleven patients with high-grade ICA stenosis (≥ 75%), confirmed by duplex sonography, underwent...

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Bibliographic Details
Main Authors: Amarteifio, Erick (Author) , Böckler, Dittmar (Author) , Attigah, Nicolas (Author) , Demirel, Serdar (Author)
Format: Article (Journal)
Language:English
Published: 2015
In: Journal of neuroradiology
Year: 2015, Volume: 42, Issue: 4, Pages: 236-244
ISSN:1773-0406
DOI:10.1016/j.neurad.2014.03.002
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1016/j.neurad.2014.03.002
Verlag, kostenfrei, Volltext: http://www.sciencedirect.com/science/article/pii/S0150986114001825
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Author Notes:E. Amarteifio, M. Essig, D. Böckler, N. Attigah, L. Schuster, S. Demirel
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Summary:Summary: Objective To prove superiority of blood pool contrast agent gadofosveset over conventional contrast agent gadobenate dimeglumine for assessment of stenotic internal carotid artery (ICA). Methods: Eleven patients with high-grade ICA stenosis (≥ 75%), confirmed by duplex sonography, underwent MR angiography (MRA) with gadofosveset and gadobenate dimeglumine. Results: Agreement in stenosis grade was reached in 7 of 10 stenotic ICAs. In two ICAs, gadobenate dimeglumine led to underestimation of stenosis grade. There was a significant difference in signal intensity (pre-/post-stenotic segments), showing higher values for gadofosveset (P < 0.01; P < 0.05). Impression of contrast intensity with gadofosveset was better in 8 ICAs and only in 1 ICA with gadobenate dimeglumine (P < 0.05). Conclusion: Gadofosveset-enhanced MR angiography may be superior for assessment of high-grade ICA stenosis compared with gadobenate dimeglumine MR angiography.
Item Description:Available online:1 July 2014
Gesehen am 30.04.2017
Physical Description:Online Resource
ISSN:1773-0406
DOI:10.1016/j.neurad.2014.03.002

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