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Revival of physostigmine: a novel HPLC assay for simultaneous determination of physostigmine and its metabolite eseroline designed for a pharmacokinetic study of septic patients

Background: Physostigmine, commonly used as an antidote in anticholinergic poisoning, is reported to have additional pharmacological effects, such as activation of the cholinergic anti-inflammatory pathway in sepsis models. Due to the narrow therapeutic range of physostigmine and its metabolite eser...

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Main Authors: Pinder, Nadine (Author) , Zimmermann, Johannes B. (Author) , Hofer, Stefan (Author) , Brenner, Thorsten (Author) , Weigand, Markus A. (Author) , Gubbe, Ute (Author) , Hoppe-Tichy, Torsten (Author) , Swoboda, Stefanie (Author)
Format: Article (Journal)
Language:English
Published: July 2015
In: Clinical chemistry and laboratory medicine
Year: 2015, Volume: 53, Issue: 8, Pages: 1259-1264
ISSN:1437-4331
DOI:10.1515/cclm-2014-0834
Online Access:Verlag, Volltext: http://dx.doi.org/10.1515/cclm-2014-0834
Verlag, Volltext: https://www.degruyterbrill.com/view/j/cclm.2015.53.issue-8/cclm-2014-0834/cclm-2014-0834.xml
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Author Notes:Nadine Pinder, Johannes B. Zimmermann, Stefan Hofer, Thorsten Brenner, Markus A. Weigand, Ute Gubbe, Torsten Hoppe-Tichy, Stefanie Swoboda
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Summary:Background: Physostigmine, commonly used as an antidote in anticholinergic poisoning, is reported to have additional pharmacological effects, such as activation of the cholinergic anti-inflammatory pathway in sepsis models. Due to the narrow therapeutic range of physostigmine and its metabolite eseroline, however, the plasma concentrations of these substances need to be determined so as to understand their effect and ensure safety in the treatment of septic patients.
Item Description:Gesehen am 04.04.2017
Physical Description:Online Resource
ISSN:1437-4331
DOI:10.1515/cclm-2014-0834

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