Next-generation (epi)genetic drivers of childhood brain tumours and the outlook for targeted therapies
Summary: Arguably, nowhere has there been a greater advance in our understanding of biological mechanisms and potential translational targets during the next-generation sequencing era than in paediatric brain tumours. The so-called omics revolution, enabled by high-throughput sequencing, has empower...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
27 May 2015
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| In: |
The lancet. Oncology
Year: 2015, Jahrgang: 16, Heft: 6, Pages: e293-e302 |
| ISSN: | 1474-5488 |
| DOI: | 10.1016/S1470-2045(14)71206-9 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/S1470-2045(14)71206-9 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S1470204514712069 
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| Verfasserangaben: | Paul A Northcott, Stefan M Pfister, David TW Jones |
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| 520 | |a Summary: Arguably, nowhere has there been a greater advance in our understanding of biological mechanisms and potential translational targets during the next-generation sequencing era than in paediatric brain tumours. The so-called omics revolution, enabled by high-throughput sequencing, has empowered large consortia and independent groups alike to make major genetic discoveries, from dominant-negative histone mutations and hijacking of distal enhancer elements, to new oncogenic gene fusions and aberrantly active gene expression. Epigenetic deregulation has also been revealed as a common theme across several tumour subtypes. This Review focuses on key findings that have been transforming the landscape of paediatric neuro-oncology research and how these results are opening new avenues towards potential therapeutic translation. | ||
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