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Reconstitution of TGFBR2-mediated signaling causes upregulation of GDF-15 in HCT116 colorectal cancer cells

Although inactivating frameshift mutations in the Transforming growth factor beta receptor type 2 (TGFBR2) gene are considered as drivers of microsatellite unstable (MSI) colorectal tumorigenesis, consequential alterations of the downstream target proteome are not resolved completely. Applying a cli...

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Main Authors: Lee, Jennifer (Author) , Fricke, Fabia (Author) , Kopitz, Jürgen (Author) , Gebert, Johannes (Author)
Format: Article (Journal)
Language:English
Published: 26 June 2015
In: PLOS ONE
Year: 2015, Volume: 10, Issue: 6
ISSN:1932-6203
DOI:10.1371/journal.pone.0131506
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1371/journal.pone.0131506
Verlag, kostenfrei, Volltext: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484253/
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Author Notes:Jennifer Lee, Fabia Fricke, Uwe Warnken, Martina Schnölzer, Jürgen Kopitz, Johannes Gebert

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