An ancient chordin-like gene in organizer formation of Hydra
Signaling centers or organizers play a key role in axial patterning processes in animal embryogenesis. The function of most vertebrate organizers involves the activity of secreted antagonists of bone morphogenetic proteins (BMPs) such as Chordin or Noggin. Although BMP homologs have been isolated fr...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
February 27, 2007
|
| In: |
Proceedings of the National Academy of Sciences of the United States of America
Year: 2007, Jahrgang: 104, Heft: 9, Pages: 3249-3254 |
| ISSN: | 1091-6490 |
| DOI: | 10.1073/pnas.0604501104 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1073/pnas.0604501104 Verlag, kostenfrei, Volltext: http://www.pnas.org/content/104/9/3249 
|
| Verfasserangaben: | Fabian Rentzsch, Corina Guder, Dirk Vocke, Bert Hobmayer, Thomas W. Holstein |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1558296999 | ||
| 003 | DE-627 | ||
| 005 | 20220813164847.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 170508s2007 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1073/pnas.0604501104 |2 doi | |
| 035 | |a (DE-627)1558296999 | ||
| 035 | |a (DE-576)488296994 | ||
| 035 | |a (DE-599)BSZ488296994 | ||
| 035 | |a (OCoLC)1340973347 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Rentzsch, Fabian |d 1969- |e VerfasserIn |0 (DE-588)124530281 |0 (DE-627)363400494 |0 (DE-576)294216936 |4 aut | |
| 245 | 1 | 3 | |a An ancient chordin-like gene in organizer formation of Hydra |c Fabian Rentzsch, Corina Guder, Dirk Vocke, Bert Hobmayer, Thomas W. Holstein |
| 264 | 1 | |c February 27, 2007 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 08.05.2017 | ||
| 520 | |a Signaling centers or organizers play a key role in axial patterning processes in animal embryogenesis. The function of most vertebrate organizers involves the activity of secreted antagonists of bone morphogenetic proteins (BMPs) such as Chordin or Noggin. Although BMP homologs have been isolated from many phyla, the evolutionary origin of the antagonistic BMP/Chordin system in organizer signaling is presently unknown. Here we describe a Chordin-like molecule (HyChdl) from Hydra that inhibits BMP activity in zebrafish embryos and acts in Hydra axis formation when new head organizers are formed during budding and regeneration. hychdl transcripts are also up-regulated in the head regeneration-deficient mutant strain reg-16. Accordingly, HyChdl has a function in organizer formation, but not in head differentiation. Our data indicate that the BMP/Chordin antagonism is a basic property of metazoan signaling centers that was invented in early metazoan evolution to set up axial polarity. | ||
| 650 | 4 | |a axis formation | |
| 650 | 4 | |a bone morphogenetic protein/Chordin | |
| 650 | 4 | |a Cnidaria | |
| 650 | 4 | |a regeneration | |
| 650 | 4 | |a signaling | |
| 700 | 1 | |a Guder, Corina |d 1976- |e VerfasserIn |0 (DE-588)132693666 |0 (DE-627)525525300 |0 (DE-576)299348547 |4 aut | |
| 700 | 1 | |a Holstein, Thomas W. |d 1953- |e VerfasserIn |0 (DE-588)1057984620 |0 (DE-627)796251053 |0 (DE-576)413989178 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a National Academy of Sciences (Washington, DC) |t Proceedings of the National Academy of Sciences of the United States of America |d Washington, DC : National Acad. of Sciences, 1915 |g 104(2007), 9, Seite 3249-3254 |h Online-Ressource |w (DE-627)254235379 |w (DE-600)1461794-8 |w (DE-576)073260509 |x 1091-6490 |7 nnas |
| 773 | 1 | 8 | |g volume:104 |g year:2007 |g number:9 |g pages:3249-3254 |g extent:6 |a An ancient chordin-like gene in organizer formation of Hydra |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1073/pnas.0604501104 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://www.pnas.org/content/104/9/3249 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20170508 | ||
| 993 | |a Article | ||
| 994 | |a 2007 | ||
| 998 | |g 1057984620 |a Holstein, Thomas W. |m 1057984620:Holstein, Thomas W. |d 700000 |d 721000 |e 700000PH1057984620 |e 721000PH1057984620 |k 0/700000/ |k 1/700000/721000/ |p 5 |y j | ||
| 998 | |g 132693666 |a Guder, Corina |m 132693666:Guder, Corina |d 700000 |d 721000 |e 700000PG132693666 |e 721000PG132693666 |k 0/700000/ |k 1/700000/721000/ |p 2 | ||
| 999 | |a KXP-PPN1558296999 |e 2968921398 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.1073/pnas.0604501104"],"eki":["1558296999"]},"origin":[{"dateIssuedDisp":"February 27, 2007","dateIssuedKey":"2007"}],"name":{"displayForm":["Fabian Rentzsch, Corina Guder, Dirk Vocke, Bert Hobmayer, Thomas W. Holstein"]},"relHost":[{"title":[{"title":"Proceedings of the National Academy of Sciences of the United States of America","title_sort":"Proceedings of the National Academy of Sciences of the United States of America"}],"note":["Gesehen am 09.03.2022"],"disp":"National Academy of Sciences (Washington, DC)Proceedings of the National Academy of Sciences of the United States of America","type":{"media":"Online-Ressource","bibl":"periodical"},"corporate":[{"role":"aut","display":"National Academy of Sciences","roleDisplay":"VerfasserIn"}],"language":["eng"],"recId":"254235379","pubHistory":["1.1915 -"],"part":{"volume":"104","text":"104(2007), 9, Seite 3249-3254","extent":"6","year":"2007","pages":"3249-3254","issue":"9"},"titleAlt":[{"title":"PNAS online"},{"title":"PNAS"}],"origin":[{"dateIssuedKey":"1915","publisher":"National Acad. of Sciences","dateIssuedDisp":"1915-","publisherPlace":"Washington, DC"}],"id":{"issn":["1091-6490"],"eki":["254235379"],"zdb":["1461794-8"]},"physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"extent":"6 S."}],"title":[{"title":"An ancient chordin-like gene in organizer formation of Hydra","title_sort":"ancient chordin-like gene in organizer formation of Hydra"}],"person":[{"role":"aut","display":"Rentzsch, Fabian","roleDisplay":"VerfasserIn","given":"Fabian","family":"Rentzsch"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Guder, Corina","given":"Corina","family":"Guder"},{"display":"Holstein, Thomas W.","roleDisplay":"VerfasserIn","role":"aut","family":"Holstein","given":"Thomas W."}],"recId":"1558296999","language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 08.05.2017"]} | ||
| SRT | |a RENTZSCHFAANCIENTCHO2720 | ||