A peptide-gated ion channel from the freshwater polyp Hydra
Chemical transmitters are either low molecular weight molecules or neuropeptides. As a general rule, neuropeptides activate only slow metabotropic receptors. To date, only one exception to this rule is known, the FMRFamide-activated Na+ channel (FaNaC) from snails. Until now FaNaC has been regarded...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 2, 2007
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| In: |
The journal of biological chemistry
Year: 2007, Jahrgang: 282, Heft: 48, Pages: 35098-35103 |
| ISSN: | 1083-351X |
| DOI: | 10.1074/jbc.M706849200 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1074/jbc.M706849200 Verlag, kostenfrei, Volltext: http://www.jbc.org/content/282/48/35098 
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| Verfasserangaben: | Andjelko Golubovic, Anne Kuhn, Michael Williamson, Hubert Kalbacher, Thomas W. Holstein, Cornelis J.P. Grimmelikhuijzen, and Stefan Gründer |
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| 245 | 1 | 2 | |a A peptide-gated ion channel from the freshwater polyp Hydra |c Andjelko Golubovic, Anne Kuhn, Michael Williamson, Hubert Kalbacher, Thomas W. Holstein, Cornelis J.P. Grimmelikhuijzen, and Stefan Gründer |
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| 520 | |a Chemical transmitters are either low molecular weight molecules or neuropeptides. As a general rule, neuropeptides activate only slow metabotropic receptors. To date, only one exception to this rule is known, the FMRFamide-activated Na+ channel (FaNaC) from snails. Until now FaNaC has been regarded as a curiosity, and it was not known whether peptide-gated ionotropic receptors are also present in other animal groups. Nervous systems first evolved in cnidarians, which extensively use neuropeptides. Here we report cloning from the freshwater cnidarian Hydra of a novel ion channel (Hydra sodium channel, HyNaC) that is directly gated by the neuropeptides Hydra-RFamides I and II and is related to FaNaC. The cells expressing HyNaC localize to the base of the tentacles, adjacent to the neurons producing the Hydra-RFamides, suggesting that the peptides are the natural ligands for this channel. Our results suggest that neuropeptides were already used for fast transmission in ancient nervous systems. | ||
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