Cover Image

The Wnt code: cnidarians signal the way

Cnidarians are the simplest metazoans with a nervous system. They are well known for their regeneration capacity, which is based on the restoration of a signalling centre (organizer). Recent work has identified the canonical Wnt pathway in the freshwater polyp Hydra, where it acts in organizer forma...

Full description

Saved in:
Bibliographic Details
Main Authors: Guder, Corina (Author) , Lengfeld, Tobias (Author) , Watanabe, Hiroshi (Author) , Holstein, Thomas W. (Author)
Format: Article (Journal)
Language:English
Published: [2006]
In: Oncogene
Year: 2006, Volume: 25, Issue: 57, Pages: 7450-7460
ISSN:1476-5594
DOI:10.1038/sj.onc.1210052
Online Access:Verlag, Volltext: http://dx.doi.org/10.1038/sj.onc.1210052
Verlag, Volltext: https://www.nature.com/onc/journal/v25/n57/full/1210052a.html
Get full text
Author Notes:C. Guder, I. Philipp, T. Lengfeld, H. Watanabe, B. Hobmayer, and T.W. Holstein

MARC

LEADER 00000caa a2200000 c 4500
001 1558344721
003 DE-627
005 20220813165158.0
007 cr uuu---uuuuu
008 170509s2006 xx |||||o 00| ||eng c
024 7 |a 10.1038/sj.onc.1210052  |2 doi 
035 |a (DE-627)1558344721 
035 |a (DE-576)488344727 
035 |a (DE-599)BSZ488344727 
035 |a (OCoLC)1340973461 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 32  |2 sdnb 
100 1 |a Guder, Corina  |d 1976-  |e VerfasserIn  |0 (DE-588)132693666  |0 (DE-627)525525300  |0 (DE-576)299348547  |4 aut 
245 1 4 |a The Wnt code  |b cnidarians signal the way  |c C. Guder, I. Philipp, T. Lengfeld, H. Watanabe, B. Hobmayer, and T.W. Holstein 
264 1 |c [2006] 
300 |a 11 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 09.05.2017 
520 |a Cnidarians are the simplest metazoans with a nervous system. They are well known for their regeneration capacity, which is based on the restoration of a signalling centre (organizer). Recent work has identified the canonical Wnt pathway in the freshwater polyp Hydra, where it acts in organizer formation and regeneration. Wnt signalling is also essential for cnidarian embryogenesis. In the sea anemone Nematostella vectensis 11 of the 12 known wnt gene subfamilies were identified. Different wnt genes exhibit serial and overlapping expression domains along the oral|[ndash]|aboral axis of the embryo (the |[lsquo]|wnt code|[rsquo]|). This is reminiscent of the hox code (cluster) in bilaterian embryogenesis that is, however, absent in cnidarians. It is proposed that the common ancestor of cnidarians and bilaterians invented a set of wnt genes that patterned the ancient main body axis. Major antagonists of Wnt ligands (e.g. Dkk 1|[sol]|2|[sol]|4) that were previously known only from chordates, are also present in cnidarians and exhibit a similar conserved function. The unexpectedly high level of genetic complexity of wnt genes evolved in early multi-cellular animals about 650|[thinsp]|Myr ago and suggests a radical expansion of the genetic repertoire, concurrent with the evolution of multi-cellularity and the diversification of eumetazoan body plans. 
650 4 |a axis formation 
650 4 |a Cnidaria 
650 4 |a Hydra 
650 4 |a Nematostella 
650 4 |a regeneration 
650 4 |a Wnt signalling 
700 1 |a Lengfeld, Tobias  |e VerfasserIn  |0 (DE-588)138991642  |0 (DE-627)703174096  |0 (DE-576)309331048  |4 aut 
700 1 |a Watanabe, Hiroshi  |e VerfasserIn  |0 (DE-588)1057884731  |0 (DE-627)795365381  |0 (DE-576)413889599  |4 aut 
700 1 |a Holstein, Thomas W.  |d 1953-  |e VerfasserIn  |0 (DE-588)1057984620  |0 (DE-627)796251053  |0 (DE-576)413989178  |4 aut 
773 0 8 |i Enthalten in  |t Oncogene  |d London : Springer Nature, 1997  |g 25(2006), 57, Seite 7450-7460  |h Online-Ressource  |w (DE-627)320469964  |w (DE-600)2008404-3  |w (DE-576)096188715  |x 1476-5594  |7 nnas  |a The Wnt code cnidarians signal the way 
773 1 8 |g volume:25  |g year:2006  |g number:57  |g pages:7450-7460  |g extent:11  |a The Wnt code cnidarians signal the way 
856 4 0 |u http://dx.doi.org/10.1038/sj.onc.1210052  |x Verlag  |x Resolving-System  |3 Volltext 
856 4 0 |u https://www.nature.com/onc/journal/v25/n57/full/1210052a.html  |x Verlag  |3 Volltext 
951 |a AR 
992 |a 20170509 
993 |a Article 
994 |a 2006 
998 |g 1057984620  |a Holstein, Thomas W.  |m 1057984620:Holstein, Thomas W.  |d 700000  |d 721000  |e 700000PH1057984620  |e 721000PH1057984620  |k 0/700000/  |k 1/700000/721000/  |p 6  |y j 
998 |g 1057884731  |a Watanabe, Hiroshi  |m 1057884731:Watanabe, Hiroshi  |d 700000  |d 721000  |e 700000PW1057884731  |e 721000PW1057884731  |k 0/700000/  |k 1/700000/721000/  |p 4 
998 |g 138991642  |a Lengfeld, Tobias  |m 138991642:Lengfeld, Tobias  |d 700000  |d 721000  |e 700000PL138991642  |e 721000PL138991642  |k 0/700000/  |k 1/700000/721000/  |p 3 
998 |g 132693666  |a Guder, Corina  |m 132693666:Guder, Corina  |d 700000  |d 721000  |e 700000PG132693666  |e 721000PG132693666  |k 0/700000/  |k 1/700000/721000/  |p 1  |x j 
999 |a KXP-PPN1558344721  |e 2968991981 
BIB |a Y 
SER |a journal 
JSO |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 09.05.2017"],"language":["eng"],"recId":"1558344721","person":[{"family":"Guder","given":"Corina","display":"Guder, Corina","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Lengfeld, Tobias","given":"Tobias","family":"Lengfeld"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Watanabe, Hiroshi","given":"Hiroshi","family":"Watanabe"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Holstein, Thomas W.","given":"Thomas W.","family":"Holstein"}],"title":[{"title_sort":"Wnt code","subtitle":"cnidarians signal the way","title":"The Wnt code"}],"physDesc":[{"extent":"11 S."}],"relHost":[{"title":[{"title_sort":"Oncogene","title":"Oncogene","subtitle":"including Oncogene reviews"}],"part":{"extent":"11","text":"25(2006), 57, Seite 7450-7460","volume":"25","pages":"7450-7460","issue":"57","year":"2006"},"pubHistory":["Nachgewiesen 14.1997 -"],"language":["eng"],"recId":"320469964","note":["Gesehen am 18.03.05"],"disp":"The Wnt code cnidarians signal the wayOncogene","type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"zdb":["2008404-3"],"eki":["320469964"],"issn":["1476-5594"]},"origin":[{"publisherPlace":"London ; Basingstoke","dateIssuedDisp":"1997-","publisher":"Springer Nature ; Nature Publ. Group","dateIssuedKey":"1997"}],"physDesc":[{"extent":"Online-Ressource"}]}],"name":{"displayForm":["C. Guder, I. Philipp, T. Lengfeld, H. Watanabe, B. Hobmayer, and T.W. Holstein"]},"origin":[{"dateIssuedDisp":"[2006]","dateIssuedKey":"2006"}],"id":{"doi":["10.1038/sj.onc.1210052"],"eki":["1558344721"]}} 
SRT |a GUDERCORINWNTCODE2006 

Similar Items