Nanopatterns biofunctionalized with cell adhesion molecule DM-GRASP offered as cell substrate: spacing determines attachment and differentiation of neurons
The density/spacing of plasma membrane proteins is thought to be crucial for their function; clear-cut experimental evidence, however, is still rare. We examined nanopatterns biofunctionalized with cell adhesion molecule DM-GRASP with respect to their impact on neuron attachment and neurite growth....
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| Main Authors: | , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
August 20, 2009
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| In: |
Nano letters
Year: 2009, Volume: 9, Issue: 12, Pages: 4115-4121 |
| ISSN: | 1530-6992 |
| DOI: | 10.1021/nl9023325 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1021/nl9023325
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| Author Notes: | Steffen Jaehrling, Karsten Thelen, Tobias Wolfram, and G. Elisabeth Pollerberg |
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| 520 | |a The density/spacing of plasma membrane proteins is thought to be crucial for their function; clear-cut experimental evidence, however, is still rare. We examined nanopatterns biofunctionalized with cell adhesion molecule DM-GRASP with respect to their impact on neuron attachment and neurite growth. Data analysis/modeling revealed that these cellular responses improve with increasing DM-GRASP density, with the exception of one spacing which does not allow for the anchorage of a cytoskeletal protein (spectrin) to three DM-GRASP molecules. | ||
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