A WNK kinase binds and phosphorylates V-ATPase subunit C
WNK (with no lysine (K)) protein kinases are found in many eukaryotes and share a unique active site. Here, we report that a member of the Arabidopsis WNK family (AtWNK8) interacts with subunit C of the vacuolar H+-ATPase (V-ATPase) via a short C-terminal domain. AtWNK8 is shown to autophosphorylate...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
18 January 2006
|
| In: |
FEBS letters
Year: 2006, Jahrgang: 580, Heft: 3, Pages: 932-939 |
| ISSN: | 1873-3468 |
| DOI: | 10.1016/j.febslet.2006.01.018 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1016/j.febslet.2006.01.018 Verlag, kostenfrei, Volltext: http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2006.01.018/abstract |
| Verfasserangaben: | Anne Hong-Hermesdorf, Angela Brüx, Ardina Grüber, Gerhard Grüber, Karin Schumacher |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 155836756X | ||
| 003 | DE-627 | ||
| 005 | 20220813165434.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 170509s2006 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.febslet.2006.01.018 |2 doi | |
| 035 | |a (DE-627)155836756X | ||
| 035 | |a (DE-576)488367565 | ||
| 035 | |a (DE-599)BSZ488367565 | ||
| 035 | |a (OCoLC)1340973467 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Hong-Hermesdorf, Anne |e VerfasserIn |0 (DE-588)1131662229 |0 (DE-627)886306361 |0 (DE-576)488367298 |4 aut | |
| 245 | 1 | 2 | |a A WNK kinase binds and phosphorylates V-ATPase subunit C |c Anne Hong-Hermesdorf, Angela Brüx, Ardina Grüber, Gerhard Grüber, Karin Schumacher |
| 264 | 1 | |c 18 January 2006 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 09.05.2017 | ||
| 520 | |a WNK (with no lysine (K)) protein kinases are found in many eukaryotes and share a unique active site. Here, we report that a member of the Arabidopsis WNK family (AtWNK8) interacts with subunit C of the vacuolar H+-ATPase (V-ATPase) via a short C-terminal domain. AtWNK8 is shown to autophosphorylate intermolecularly and to phosphorylate Arabidopsis subunit C (AtVHA-C) at multiple sites as determined by MALDI-TOF MS analysis. Furthermore, we show that AtVHA-C and other V-ATPase subunits are phosphorylated when V1-complexes are used as substrates for AtWNK8. Taken together, our results provide evidence that V-ATPases are potential targets of WNK kinases and their associated signaling pathways. | ||
| 650 | 4 | |a Arabidopsis | |
| 650 | 4 | |a MALDI-TOF MS | |
| 650 | 4 | |a matrix assisted laser desorption-ionisation/time-of-flight mass spectrometry | |
| 650 | 4 | |a Phosphorylation | |
| 650 | 4 | |a V1-complex | |
| 650 | 4 | |a vacuolar H+-ATPase | |
| 650 | 4 | |a vacuolar H+-ATPase subunit C | |
| 650 | 4 | |a V-ATPase | |
| 650 | 4 | |a VHA-C | |
| 650 | 4 | |a with no lysine (K) | |
| 650 | 4 | |a WNK | |
| 700 | 1 | |a Schumacher, Karin |d 1966- |e VerfasserIn |0 (DE-588)173015123 |0 (DE-627)697940241 |0 (DE-576)133868206 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a Vereinigung der Europäischen Biochemischen Gesellschaften |t FEBS letters |d Chichester : Wiley, 1968 |g 580(2006), 3, Seite 932-939 |h Online-Ressource |w (DE-627)253779669 |w (DE-600)1460391-3 |w (DE-576)07279383X |x 1873-3468 |7 nnas |
| 773 | 1 | 8 | |g volume:580 |g year:2006 |g number:3 |g pages:932-939 |g extent:8 |a A WNK kinase binds and phosphorylates V-ATPase subunit C |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.febslet.2006.01.018 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2006.01.018/abstract |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20170509 | ||
| 993 | |a Article | ||
| 994 | |a 2006 | ||
| 998 | |g 173015123 |a Schumacher, Karin |m 173015123:Schumacher, Karin |p 5 |y j | ||
| 999 | |a KXP-PPN155836756X |e 2969023709 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"family":"Hong-Hermesdorf","given":"Anne","display":"Hong-Hermesdorf, Anne","role":"aut"},{"family":"Schumacher","given":"Karin","display":"Schumacher, Karin","role":"aut"}],"title":[{"title_sort":"WNK kinase binds and phosphorylates V-ATPase subunit C","title":"A WNK kinase binds and phosphorylates V-ATPase subunit C"}],"physDesc":[{"extent":"8 S."}],"id":{"eki":["155836756X"],"doi":["10.1016/j.febslet.2006.01.018"]},"language":["eng"],"name":{"displayForm":["Anne Hong-Hermesdorf, Angela Brüx, Ardina Grüber, Gerhard Grüber, Karin Schumacher"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"155836756X","relHost":[{"title":[{"subtitle":"for the rapid publication of short reports in biochemistry, biophysics, and molecular biology","title_sort":"FEBS letters","title":"FEBS letters"}],"part":{"extent":"8","volume":"580","issue":"3","pages":"932-939","year":"2006","text":"580(2006), 3, Seite 932-939"},"physDesc":[{"extent":"Online-Ressource"}],"disp":"Vereinigung der Europäischen Biochemischen GesellschaftenFEBS letters","type":{"media":"Online-Ressource","bibl":"periodical"},"corporate":[{"role":"aut","display":"Vereinigung der Europäischen Biochemischen Gesellschaften"}],"id":{"zdb":["1460391-3"],"eki":["253779669"],"issn":["1873-3468"],"doi":["10.1002/(ISSN)1873-3468"]},"language":["eng"],"name":{"displayForm":["Federation of European Biochemical Societies. Ed. M. Avron [u.a.]"]},"recId":"253779669","origin":[{"dateIssuedKey":"1968","dateIssuedDisp":"1968-","publisher":"Wiley ; North-Holland Publ. Co. ; Elsevier","publisherPlace":"Chichester ; Amsterdam ; Amsterdam [u.a.]"}],"note":["Gesehen am 18.12.2019","Fortsetzung der Druck-Ausgabe"],"pubHistory":["1.1968 -"]}],"note":["Gesehen am 09.05.2017"],"origin":[{"dateIssuedDisp":"18 January 2006","dateIssuedKey":"2006"}]} | ||
| SRT | |a HONGHERMESWNKKINASEB1820 | ||