A conserved acidic motif is crucial for enzymatic activity of protein o-mannosyltransferases
Protein O-mannosylation is an essential modification in fungi and mammals. It is initiated at the endoplasmic reticulum by a conserved family of dolichyl phosphate mannose-dependent protein O-mannosyltransferases (PMTs). PMTs are integral membrane proteins with two hydrophilic loops (loops 1 and 5)...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
September 28, 2011
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| In: |
The journal of biological chemistry
Year: 2011, Volume: 286, Issue: 46, Pages: 39768-39775 |
| ISSN: | 1083-351X |
| DOI: | 10.1074/jbc.M111.281196 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1074/jbc.M111.281196 Verlag, kostenfrei, Volltext: http://www.jbc.org/content/286/46/39768 
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| Author Notes: | Mark Lommel, Andrea Schott, Thomas Jank, Verena Hofmann, and Sabine Strahl |