The role of cell adhesion molecules for navigating axons: density matters
Cell adhesion molecules of the immunoglobulin-super-family (IgSF-CAMs) do not only have a physical effect, mediating merely attachment between cell surfaces. For navigating axons, IgSF-CAMs also exert an instructive impact: Upon activation, they elicit intracellular signalling cascades in the tip of...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
23 November 2012
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| In: |
Mechanisms of development
Year: 2013, Jahrgang: 130, Heft: 6/8, Pages: 359-372 |
| ISSN: | 1872-6356 |
| DOI: | 10.1016/j.mod.2012.11.002 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1016/j.mod.2012.11.002 Verlag, kostenfrei, Volltext: http://www.sciencedirect.com/science/article/pii/S092547731200113X 
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| Verfasserangaben: | G.E. Pollerberg, K. Thelen, M.O. Theiss, B.C. Hochlehnert |
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| 520 | |a Cell adhesion molecules of the immunoglobulin-super-family (IgSF-CAMs) do not only have a physical effect, mediating merely attachment between cell surfaces. For navigating axons, IgSF-CAMs also exert an instructive impact: Upon activation, they elicit intracellular signalling cascades in the tip of the axon, the growth cone, which regulate in a spatio-temporally concerted action both speed and direction of the axon. Density and distribution of IgSF-CAMs in the growth cone plasma membrane play important roles for the activation of IgSF-CAMs, their clustering, and the adhesive forces they acquire, as well as for the local restriction and effective propagation of their intracellular signals. | ||
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