Buchumschlag

Bestrophin 2: An anion channel associated with neurogenesis in chemosensory systems

The chemosensory neuroepithelia of the vertebrate olfactory system share a life-long ability to regenerate. Novel neurons proliferate from basal stem cells that continuously replace old or damaged sensory neurons. The sensory neurons of the mouse and rat olfactory system specifically express bestrop...

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Hauptverfasser: Klimmeck, Daniel (VerfasserIn) , Daiber, Philipp (VerfasserIn) , Frings, Stephan (VerfasserIn) , Möhrlen, Frank (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2009
In: The journal of comparative neurology
Year: 2009, Jahrgang: 515, Heft: 5, Pages: 585-599
ISSN:1096-9861
DOI:10.1002/cne.22075
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1002/cne.22075
Verlag, Volltext: http://onlinelibrary.wiley.com/doi/10.1002/cne.22075/abstract
Volltext
Verfasserangaben:Daniel Klimmeck, Philipp C. Daiber, Anja Brühl, Arnd Baumann, Stephan Frings, Frank Möhrlen
Beschreibung
Zusammenfassung:The chemosensory neuroepithelia of the vertebrate olfactory system share a life-long ability to regenerate. Novel neurons proliferate from basal stem cells that continuously replace old or damaged sensory neurons. The sensory neurons of the mouse and rat olfactory system specifically express bestrophin 2, a member of the bestrophin family of calcium-activated chloride channels. This channel was recently proposed to operate as a transduction channel in olfactory sensory cilia. We raised a polyclonal antibody against bestrophin 2 and characterized the expression pattern of this protein in the mouse main olfactory epithelium, septal organ of Masera, and vomeronasal organ. Comparison with the maturation markers growth-associated protein 43 and olfactory marker protein revealed that bestrophin 2 was expressed in developing sensory neurons of all chemosensory neuroepithelia, but was restricted to proximal cilia in mature sensory neurons. Our results suggest that bestrophin 2 plays a critical role during differentiation and growth of axons and cilia. In mature olfactory receptor neurons, it appears to support growth and function of sensory cilia. J. Comp. Neurol. 515:585-599, 2009. © 2009 Wiley-Liss, Inc.
Beschreibung:Online Resource
ISSN:1096-9861
DOI:10.1002/cne.22075

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