Buchumschlag

Phosphorylation of ZEN-4/MKLP1 by Aurora B regulates completion of cytokinesis

Summary The central spindle regulates the formation and positioning of the contractile ring and is essential for completion of cytokinesis [1]. Central spindle assembly begins in early anaphase with the bundling of overlapping, antiparallel, nonkinetochore microtubules [2, 3], and these bundles beco...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Guse, Annika (VerfasserIn) , Mishima, Masanori (VerfasserIn) , Glotzer, Michael (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: April 26, 2005
In: Current biology
Year: 2005, Jahrgang: 15, Heft: 8, Pages: 778-786
ISSN:1879-0445
DOI:10.1016/j.cub.2005.03.041
Online-Zugang:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1016/j.cub.2005.03.041
Verlag, kostenfrei, Volltext: http://www.sciencedirect.com/science/article/pii/S0960982205003350
Volltext
Verfasserangaben:Annika Guse, Masanori Mishima and Michael Glotzer

MARC

LEADER 00000caa a2200000 c 4500
001 1558389350
003 DE-627
005 20220813165925.0
007 cr uuu---uuuuu
008 170510s2005 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.cub.2005.03.041  |2 doi 
035 |a (DE-627)1558389350 
035 |a (DE-576)488389356 
035 |a (DE-599)BSZ488389356 
035 |a (OCoLC)1340973835 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 32  |2 sdnb 
100 1 |a Guse, Annika  |e VerfasserIn  |0 (DE-588)1079253254  |0 (DE-627)840692730  |0 (DE-576)452309247  |4 aut 
245 1 0 |a Phosphorylation of ZEN-4/MKLP1 by Aurora B regulates completion of cytokinesis  |c Annika Guse, Masanori Mishima and Michael Glotzer 
264 1 |c April 26, 2005 
300 |a 9 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 10.05.2017 
520 |a Summary The central spindle regulates the formation and positioning of the contractile ring and is essential for completion of cytokinesis [1]. Central spindle assembly begins in early anaphase with the bundling of overlapping, antiparallel, nonkinetochore microtubules [2, 3], and these bundles become compacted and mature into the midbody. Prominent components of the central spindle include aurora B kinase and centralspindlin, a complex containing a Kinesin-6 protein (ZEN-4/MKLP1) and a Rho family GAP (CYK-4/MgcRacGAP) that is essential for central spindle assembly [4]. Centralspindlin localization depends on aurora B kinase [5]. Aurora B concentrates in the midbody and persists between daughter cells. Here, we show that in C. elegans embryos and in cultured human cells, respectively, ZEN-4 and MKLP1 are phosphorylated by aurora B in vitro and in vivo on conserved C-terminal serine residues. In C. elegans embryos, a nonphosphorylatable mutant of ZEN-4 localizes properly but does not efficiently support completion of cytokinesis. In mammalian cells, an inhibitor of aurora kinase acutely attenuates phosphorylation of MKLP1. Inhibition of aurora B in late anaphase causes cytokinesis defects without disrupting the central spindle. These data indicate a conserved role for aurora-B-mediated phosphorylation of ZEN-4/MKLP1 in the completion of cytokinesis. 
700 1 |a Mishima, Masanori  |e VerfasserIn  |0 (DE-588)1131884418  |0 (DE-627)886930030  |0 (DE-576)488549434  |4 aut 
700 1 |a Glotzer, Michael  |e VerfasserIn  |0 (DE-588)1131884280  |0 (DE-627)886929814  |0 (DE-576)488548799  |4 aut 
773 0 8 |i Enthalten in  |t Current biology  |d Cambridge, MA : Cell Press, 1991  |g 15(2005), 8, Seite 778-786  |h Online-Ressource  |w (DE-627)320593223  |w (DE-600)2019214-9  |w (DE-576)093983190  |x 1879-0445  |7 nnas  |a Phosphorylation of ZEN-4/MKLP1 by Aurora B regulates completion of cytokinesis 
773 1 8 |g volume:15  |g year:2005  |g number:8  |g pages:778-786  |g extent:9  |a Phosphorylation of ZEN-4/MKLP1 by Aurora B regulates completion of cytokinesis 
856 4 0 |u http://dx.doi.org/10.1016/j.cub.2005.03.041  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u http://www.sciencedirect.com/science/article/pii/S0960982205003350  |x Verlag  |z kostenfrei  |3 Volltext 
951 |a AR 
992 |a 20170510 
993 |a Article 
994 |a 2005 
998 |g 1079253254  |a Guse, Annika  |m 1079253254:Guse, Annika  |p 1  |x j 
999 |a KXP-PPN1558389350  |e 2969052814 
BIB |a Y 
SER |a journal 
JSO |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 10.05.2017"],"language":["eng"],"recId":"1558389350","person":[{"display":"Guse, Annika","roleDisplay":"VerfasserIn","role":"aut","family":"Guse","given":"Annika"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Mishima, Masanori","given":"Masanori","family":"Mishima"},{"display":"Glotzer, Michael","roleDisplay":"VerfasserIn","role":"aut","family":"Glotzer","given":"Michael"}],"title":[{"title_sort":"Phosphorylation of ZEN-4/MKLP1 by Aurora B regulates completion of cytokinesis","title":"Phosphorylation of ZEN-4/MKLP1 by Aurora B regulates completion of cytokinesis"}],"physDesc":[{"extent":"9 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1879-0445"],"eki":["320593223"],"zdb":["2019214-9"]},"origin":[{"publisherPlace":"Cambridge, MA ; London","publisher":"Cell Press ; Current Biology Ltd.","dateIssuedKey":"1991","dateIssuedDisp":"1991-"}],"titleAlt":[{"title":"CB"}],"part":{"pages":"778-786","issue":"8","year":"2005","extent":"9","volume":"15","text":"15(2005), 8, Seite 778-786"},"pubHistory":["1.1991 -"],"recId":"320593223","language":["eng"],"disp":"Phosphorylation of ZEN-4/MKLP1 by Aurora B regulates completion of cytokinesisCurrent biology","type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 02.08.24"],"title":[{"subtitle":"CB","title":"Current biology","title_sort":"Current biology"}]}],"name":{"displayForm":["Annika Guse, Masanori Mishima and Michael Glotzer"]},"origin":[{"dateIssuedDisp":"April 26, 2005","dateIssuedKey":"2005"}],"id":{"eki":["1558389350"],"doi":["10.1016/j.cub.2005.03.041"]}} 
SRT |a GUSEANNIKAPHOSPHORYL2620 

Ähnliche Einträge