Reversion of lethality and growth defects in Fatiga oxygen‐sensor mutant flies by loss of Hypoxia‐Inducible Factor‐α/Sima
Hypoxia‐Inducible Factor (HIF) prolyl hydroxylase domains (PHDs) have been proposed to act as sensors that have an important role in oxygen homeostasis. In the presence of oxygen, they hydroxylate two specific prolyl residues in HIF‐α polypeptides, thereby promoting their proteasomal degradation. So...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
01.11.2005
|
| In: |
EMBO reports
Year: 2005, Jahrgang: 6, Heft: 11, Pages: 1070-1075 |
| ISSN: | 1469-3178 |
| DOI: | 10.1038/sj.embor.7400528 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/sj.embor.7400528 Verlag, kostenfrei, Volltext: http://embor.embopress.org/content/6/11/1070 
|
| Verfasserangaben: | Lázaro Centanin, Peter J. Ratcliffe & Pablo Wappner |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 155839320X | ||
| 003 | DE-627 | ||
| 005 | 20220813165950.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 170510s2005 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/sj.embor.7400528 |2 doi | |
| 035 | |a (DE-627)155839320X | ||
| 035 | |a (DE-576)488393205 | ||
| 035 | |a (DE-599)BSZ488393205 | ||
| 035 | |a (OCoLC)1340973792 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Centanin, Lázaro |e VerfasserIn |0 (DE-588)105927664X |0 (DE-627)798228431 |0 (DE-576)415156548 |4 aut | |
| 245 | 1 | 0 | |a Reversion of lethality and growth defects in Fatiga oxygen‐sensor mutant flies by loss of Hypoxia‐Inducible Factor‐α/Sima |c Lázaro Centanin, Peter J. Ratcliffe & Pablo Wappner |
| 264 | 1 | |c 01.11.2005 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 10.05.2017 | ||
| 520 | |a Hypoxia‐Inducible Factor (HIF) prolyl hydroxylase domains (PHDs) have been proposed to act as sensors that have an important role in oxygen homeostasis. In the presence of oxygen, they hydroxylate two specific prolyl residues in HIF‐α polypeptides, thereby promoting their proteasomal degradation. So far, however, the developmental consequences of the inactivation of PHDs in higher metazoans have not been reported. Here, we describe novel loss‐of‐function mutants of fatiga, the gene encoding the Drosophila PHD oxygen sensor, which manifest growth defects and lethality. We also report a null mutation in dHIF‐α/sima, which is unable to adapt to hypoxia but is fully viable in normoxic conditions. Strikingly, loss‐of‐function mutations of sima rescued the developmental defects observed in fatiga mutants and enabled survival to adulthood. These results indicate that the main functions of Fatiga in development, including control of cell size, involve the regulation of dHIF/Sima. | ||
| 650 | 4 | |a Drosophila | |
| 650 | 4 | |a hypoxia‐inducible factor | |
| 650 | 4 | |a oxygen sensor | |
| 650 | 4 | |a Sima | |
| 773 | 0 | 8 | |i Enthalten in |a European Molecular Biology Organization |t EMBO reports |d [London] : Nature Publishing Group UK, 2000 |g 6(2005), 11, Seite 1070-1075 |h Online-Ressource |w (DE-627)320645622 |w (DE-600)2025376-X |w (DE-576)095092153 |x 1469-3178 |7 nnas |
| 773 | 1 | 8 | |g volume:6 |g year:2005 |g number:11 |g pages:1070-1075 |g extent:6 |a Reversion of lethality and growth defects in Fatiga oxygen‐sensor mutant flies by loss of Hypoxia‐Inducible Factor‐α/Sima |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/sj.embor.7400528 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://embor.embopress.org/content/6/11/1070 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20170510 | ||
| 993 | |a Article | ||
| 994 | |a 2005 | ||
| 998 | |g 105927664X |a Centanin, Lázaro |m 105927664X:Centanin, Lázaro |p 1 |x j | ||
| 999 | |a KXP-PPN155839320X |e 2969057611 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"6 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"name":{"displayForm":["European Molecular Biology Organization"]},"id":{"zdb":["2025376-X"],"eki":["320645622"],"doi":["10.1002/(ISSN)1469-3178"],"issn":["1469-3178"]},"origin":[{"publisher":"Nature Publishing Group UK ; EMBO Press ; Oxford Univ. Press ; Nature Publishing Group ; Wiley","dateIssuedDisp":"[2000]-","publisherPlace":"[London] ; Heidelberg ; Oxford [u.a.] ; London [u.a.] ; Hoboken, NJ [u.a.]"}],"recId":"320645622","corporate":[{"role":"aut","roleDisplay":"VerfasserIn","display":"European Molecular Biology Organization"}],"language":["eng"],"disp":"European Molecular Biology OrganizationEMBO reports","note":["Fortsetzung der Druck-Ausgabe","Gesehen am 11.03.25"],"type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"issue":"11","pages":"1070-1075","year":"2005","extent":"6","text":"6(2005), 11, Seite 1070-1075","volume":"6"},"pubHistory":["1.2000 -"],"title":[{"title_sort":"EMBO reports","title":"EMBO reports"}]}],"name":{"displayForm":["Lázaro Centanin, Peter J. Ratcliffe & Pablo Wappner"]},"origin":[{"dateIssuedKey":"2005","dateIssuedDisp":"01.11.2005"}],"id":{"doi":["10.1038/sj.embor.7400528"],"eki":["155839320X"]},"note":["Gesehen am 10.05.2017"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"recId":"155839320X","person":[{"family":"Centanin","given":"Lázaro","roleDisplay":"VerfasserIn","display":"Centanin, Lázaro","role":"aut"}],"title":[{"title_sort":"Reversion of lethality and growth defects in Fatiga oxygen‐sensor mutant flies by loss of Hypoxia‐Inducible Factor‐α/Sima","title":"Reversion of lethality and growth defects in Fatiga oxygen‐sensor mutant flies by loss of Hypoxia‐Inducible Factor‐α/Sima"}]} | ||
| SRT | |a CENTANINLAREVERSIONO0111 | ||