Inhibition of 5’-methylthioadenosine metabolism in the Yang cycle alters polyamine levels, and impairs seedling growth and reproduction in Arabidopsis
The methionine or Yang cycle recycles Met from 5’-methylthioadenosine (MTA) which is produced from S-adenosyl-L-methionine (SAM) as a by-product of ethylene, polyamines, and nicotianamine (NA) synthesis. MTA nucleosidase is encoded by two genes in Arabidopsis thaliana, MTN1 and MTN2. Analysis of T-D...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
9 June 2010
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| In: |
The plant journal
Year: 2010, Jahrgang: 62, Heft: 6, Pages: 977-988 |
| ISSN: | 1365-313X |
| DOI: | 10.1111/j.1365-313X.2010.04211.x |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1111/j.1365-313X.2010.04211.x Verlag, kostenfrei, Volltext: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-313X.2010.04211.x/abstract 
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| Verfasserangaben: | Katharina Bürstenbinder, Ishari Waduwara, Sarah Schoor, Barbara A. Moffatt, Markus Wirtz, Subhash C. Minocha, Yasmin Oppermann, Alain Bouchereau, Rüdiger Hell and Margret Sauter |
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| 245 | 1 | 0 | |a Inhibition of 5’-methylthioadenosine metabolism in the Yang cycle alters polyamine levels, and impairs seedling growth and reproduction in Arabidopsis |c Katharina Bürstenbinder, Ishari Waduwara, Sarah Schoor, Barbara A. Moffatt, Markus Wirtz, Subhash C. Minocha, Yasmin Oppermann, Alain Bouchereau, Rüdiger Hell and Margret Sauter |
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| 520 | |a The methionine or Yang cycle recycles Met from 5’-methylthioadenosine (MTA) which is produced from S-adenosyl-L-methionine (SAM) as a by-product of ethylene, polyamines, and nicotianamine (NA) synthesis. MTA nucleosidase is encoded by two genes in Arabidopsis thaliana, MTN1 and MTN2. Analysis of T-DNA insertion mutants and of wt revealed that MTN1 provides approximately 80% of the total MTN activity. Severe knock down of MTN enzyme activity in the mtn1-1 and mtn1-2 allelic lines resulted in accumulation of SAM/dSAM (decarboxylated SAM) and of MTA in seedlings grown on MTA as sulfur source. While ethylene and NA synthesis were not altered in mtn1-1 and mtn1-2 seedlings grown on MTA, putrescine and spermine were elevated. By contrast, mtn2-1 and mtn2-2 seedlings with near wt enzyme activity had wt levels of SAM/dSAM, MTA, and polyamines. In addition to the metabolic phenotypes, mtn1-1 and mtn1-2 seedlings were growth retarded, while seedlings of wt, mtn2-1, and mtn2-2 showed normal growth on 500 μm MTA. The double knock down mutant mtn1-1/mtn2-1 was sterile. In conclusion, the data presented identify MTA as a crucial metabolite that acts as a regulatory link between the Yang cycle and polyamine biosynthesis and identifies MTA nucleosidase as a crucial enzyme of the Yang cycle. | ||
| 650 | 4 | |a 5’-methylthioadenosine nucleosidase | |
| 650 | 4 | |a Arabidopsis seedling growth | |
| 650 | 4 | |a ethylene | |
| 650 | 4 | |a methylthioadenosine | |
| 650 | 4 | |a polyamines | |
| 650 | 4 | |a sulfur metabolism | |
| 650 | 4 | |a Yang cycle | |
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| 700 | 1 | |a Hell, Rüdiger |e VerfasserIn |0 (DE-588)1022964933 |0 (DE-627)717340341 |0 (DE-576)166399647 |4 aut | |
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