Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland
Transcription factor CREM appears to play a key physiological and developmental role within the hypothalamic-pituitary-gonadal axis. This axis is modulated by the pineal hormone melatonin, whose production is in turn driven by the endogenous clock. There is striking circadian fluctuation of a novel...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
23 September 1993
|
| In: |
Nature
Year: 1993, Jahrgang: 365, Heft: 6444, Pages: 314-320 |
| ISSN: | 1476-4687 |
| DOI: | 10.1038/365314a0 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1038/365314a0 Verlag, Volltext: https://www.nature.com/nature/journal/v365/n6444/abs/365314a0.html 
|
| Verfasserangaben: | Jörg H. Stehle, Nicholas S. Foulkes, Carlos A. Molina, Valérie Simonneaux, Paul Pévet & Paolo Sassone-Corsi |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1558572996 | ||
| 003 | DE-627 | ||
| 005 | 20220813171541.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 170512s1993 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/365314a0 |2 doi | |
| 035 | |a (DE-627)1558572996 | ||
| 035 | |a (DE-576)488572991 | ||
| 035 | |a (DE-599)BSZ488572991 | ||
| 035 | |a (OCoLC)1340975237 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Stehle, Jörg H. |d 1954- |e VerfasserIn |0 (DE-588)118092197 |0 (DE-627)079239161 |0 (DE-576)291711774 |4 aut | |
| 245 | 1 | 0 | |a Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland |c Jörg H. Stehle, Nicholas S. Foulkes, Carlos A. Molina, Valérie Simonneaux, Paul Pévet & Paolo Sassone-Corsi |
| 264 | 1 | |c 23 September 1993 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 12.05.2017 | ||
| 520 | |a Transcription factor CREM appears to play a key physiological and developmental role within the hypothalamic-pituitary-gonadal axis. This axis is modulated by the pineal hormone melatonin, whose production is in turn driven by the endogenous clock. There is striking circadian fluctuation of a novel CREM isoform, ICER, which is expressed at high levels during the night. ICER is generated from an alternative, intronic promoter and functions as a powerful represser of cyclic AMP-induced transcription. Rhythmic adrenergic signals originated by the clock direct ICER expression by stimulation of the cAMP signal transduction pathway. | ||
| 700 | 1 | |a Foulkes, Nicholas S. |d 1963- |e VerfasserIn |0 (DE-588)1081431695 |0 (DE-627)84611044X |0 (DE-576)454404999 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature |d London [u.a.] : Nature Publ. Group, 1869 |g 365(1993), 6444, Seite 314-320 |h Online-Ressource |w (DE-627)240151402 |w (DE-600)1413423-8 |w (DE-576)079718426 |x 1476-4687 |7 nnas |a Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland |
| 773 | 1 | 8 | |g volume:365 |g year:1993 |g number:6444 |g pages:314-320 |g extent:7 |a Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/365314a0 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/nature/journal/v365/n6444/abs/365314a0.html |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20170512 | ||
| 993 | |a Article | ||
| 994 | |a 1993 | ||
| 998 | |g 1081431695 |a Foulkes, Nicholas S. |m 1081431695:Foulkes, Nicholas S. |d 700000 |d 721000 |e 700000PF1081431695 |e 721000PF1081431695 |k 0/700000/ |k 1/700000/721000/ |p 2 | ||
| 999 | |a KXP-PPN1558572996 |e 2969397048 | ||
| BIB | |a Y | ||
| SER | |a newspaper | ||
| JSO | |a {"note":["Gesehen am 12.05.2017"],"type":{"media":"Online-Ressource","bibl":"article-newspaper"},"language":["eng"],"recId":"1558572996","title":[{"title":"Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland","title_sort":"Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland"}],"person":[{"given":"Jörg H.","family":"Stehle","role":"aut","display":"Stehle, Jörg H.","roleDisplay":"VerfasserIn"},{"display":"Foulkes, Nicholas S.","roleDisplay":"VerfasserIn","role":"aut","family":"Foulkes","given":"Nicholas S."}],"physDesc":[{"extent":"7 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["240151402"],"zdb":["1413423-8"],"issn":["1476-4687"]},"origin":[{"publisherPlace":"London [u.a.] ; London","publisher":"Nature Publ. Group ; Macmillan","dateIssuedKey":"1869","dateIssuedDisp":"1869-"}],"part":{"volume":"365","text":"365(1993), 6444, Seite 314-320","extent":"7","year":"1993","issue":"6444","pages":"314-320"},"titleAlt":[{"title":"Nature <London>"},{"title":"Nature"}],"pubHistory":["1.1869/70 - ; auch mit durchgehender Nr.-Zählung"],"language":["eng"],"recId":"240151402","disp":"Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal glandNature","type":{"media":"Online-Ressource","bibl":"newspaper"},"note":["Gesehen am 19.02.2019"],"title":[{"subtitle":"international weekly journal of science","title":"Nature","title_sort":"Nature"}]}],"origin":[{"dateIssuedKey":"1993","dateIssuedDisp":"23 September 1993"}],"id":{"doi":["10.1038/365314a0"],"eki":["1558572996"]},"name":{"displayForm":["Jörg H. Stehle, Nicholas S. Foulkes, Carlos A. Molina, Valérie Simonneaux, Paul Pévet & Paolo Sassone-Corsi"]}} | ||
| SRT | |a STEHLEJOERADRENERGIC2319 | ||