Impaired mucus clearance exacerbates allergen-induced type 2 airway inflammation in juvenile mice
Type 2 airway inflammation plays a central role in the pathogenesis of allergen-induced asthma, but the underlying mechanisms remain poorly understood. Recently, we demonstrated that reduced mucociliary clearance, a characteristic feature of asthma, produces spontaneous type 2 airway inflammation in...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 2017
|
| In: |
The journal of allergy and clinical immunology
Year: 2017, Jahrgang: 140, Heft: 1, Pages: 190-203.e5 |
| ISSN: | 1097-6825 |
| DOI: | 10.1016/j.jaci.2016.09.045 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.jaci.2016.09.045 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0091674916312969 
|
| Verfasserangaben: | Benedikt Fritzsching, Matthias Hagner, Lu Dai, Sandra Christochowitz, Raman Agrawal, Charlotte van Bodegom, Simone Schmidt, Jolanthe Schatterny, Stephanie Hirtz, Ryan Brown, Michelle Goritzka, Julia Duerr, Zhe Zhou-Suckow, and Marcus A. Mall |
| Zusammenfassung: | Type 2 airway inflammation plays a central role in the pathogenesis of allergen-induced asthma, but the underlying mechanisms remain poorly understood. Recently, we demonstrated that reduced mucociliary clearance, a characteristic feature of asthma, produces spontaneous type 2 airway inflammation in juvenile β-epithelial Na+ channel (Scnn1b)-transgenic (Tg) mice. |
|---|---|
| Beschreibung: | Gesehen am 03.07.2017 |
| Beschreibung: | Online Resource |
| ISSN: | 1097-6825 |
| DOI: | 10.1016/j.jaci.2016.09.045 |