Simple fold composition and modular architecture of the nuclear pore complex
The nuclear pore complex (NPC) consists of multiple copies of ≈30 different proteins [nucleoporins (nups)], forming a channel in the nuclear envelope that mediates macromolecular transport between the cytosol and the nucleus. With <5% of the nup residues currently available in experimentally dete...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
February 14, 2006
|
| In: |
Proceedings of the National Academy of Sciences of the United States of America
Year: 2006, Jahrgang: 103, Heft: 7, Pages: 2172-2177 |
| ISSN: | 1091-6490 |
| DOI: | 10.1073/pnas.0506345103 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1073/pnas.0506345103 Verlag, kostenfrei, Volltext: http://www.pnas.org/content/103/7/2172 
|
| Verfasserangaben: | Damien Devos, Svetlana Dokudovskaya, Rosemary Williams, Frank Alber, Narayanan Eswar, Brian T. Chait, Michael P. Rout, and Andrej Sali |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1558592873 | ||
| 003 | DE-627 | ||
| 005 | 20220813171727.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 170515s2006 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1073/pnas.0506345103 |2 doi | |
| 035 | |a (DE-627)1558592873 | ||
| 035 | |a (DE-576)488592879 | ||
| 035 | |a (DE-599)BSZ488592879 | ||
| 035 | |a (OCoLC)1340975271 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Devos, Damien |e VerfasserIn |0 (DE-588)1038353319 |0 (DE-627)766122247 |0 (DE-576)392341069 |4 aut | |
| 245 | 1 | 0 | |a Simple fold composition and modular architecture of the nuclear pore complex |c Damien Devos, Svetlana Dokudovskaya, Rosemary Williams, Frank Alber, Narayanan Eswar, Brian T. Chait, Michael P. Rout, and Andrej Sali |
| 264 | 1 | |c February 14, 2006 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 15.05.2017 | ||
| 520 | |a The nuclear pore complex (NPC) consists of multiple copies of ≈30 different proteins [nucleoporins (nups)], forming a channel in the nuclear envelope that mediates macromolecular transport between the cytosol and the nucleus. With <5% of the nup residues currently available in experimentally determined structures, little is known about the detailed structure of the NPC. Here, we use a combined computational and biochemical approach to assign folds for ≈95% of the residues in the yeast and vertebrate nups. These fold assignments suggest an underlying simplicity in the composition and modularity in the architecture of all eukaryotic NPCs. The simplicity in NPC composition is reflected in the presence of only eight fold types, with the three most frequent folds accounting for ≈85% of the residues. The modularity in NPC architecture is reflected in its hierarchical and symmetrical organization that partitions the predicted nup folds into three groups: the transmembrane group containing transmembrane helices and a cadherin fold, the central scaffold group containing β-propeller and α-solenoid folds, and the peripheral FG group containing predominantly the FG repeats and the coiled-coil fold. Moreover, similarities between structures in coated vesicles and those in the NPC support our prior hypothesis for their common evolutionary origin in a progenitor protocoatomer. The small number of predicted fold types in the NPC and their internal symmetries suggest that the bulk of the NPC structure has evolved through extensive motif and gene duplication from a simple precursor set of only a few proteins. | ||
| 650 | 4 | |a coated vesicle | |
| 650 | 4 | |a evolution | |
| 650 | 4 | |a fold assignment | |
| 650 | 4 | |a protocoatomer | |
| 773 | 0 | 8 | |i Enthalten in |a National Academy of Sciences (Washington, DC) |t Proceedings of the National Academy of Sciences of the United States of America |d Washington, DC : National Acad. of Sciences, 1915 |g 103(2006), 7, Seite 2172-2177 |h Online-Ressource |w (DE-627)254235379 |w (DE-600)1461794-8 |w (DE-576)073260509 |x 1091-6490 |7 nnas |
| 773 | 1 | 8 | |g volume:103 |g year:2006 |g number:7 |g pages:2172-2177 |g extent:6 |a Simple fold composition and modular architecture of the nuclear pore complex |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1073/pnas.0506345103 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://www.pnas.org/content/103/7/2172 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20170515 | ||
| 993 | |a Article | ||
| 994 | |a 2006 | ||
| 998 | |g 1038353319 |a Devos, Damien |m 1038353319:Devos, Damien |p 1 |x j | ||
| 999 | |a KXP-PPN1558592873 |e 2969429853 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Simple fold composition and modular architecture of the nuclear pore complex","title_sort":"Simple fold composition and modular architecture of the nuclear pore complex"}],"person":[{"family":"Devos","given":"Damien","roleDisplay":"VerfasserIn","display":"Devos, Damien","role":"aut"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 15.05.2017"],"language":["eng"],"recId":"1558592873","origin":[{"dateIssuedKey":"2006","dateIssuedDisp":"February 14, 2006"}],"id":{"doi":["10.1073/pnas.0506345103"],"eki":["1558592873"]},"name":{"displayForm":["Damien Devos, Svetlana Dokudovskaya, Rosemary Williams, Frank Alber, Narayanan Eswar, Brian T. Chait, Michael P. Rout, and Andrej Sali"]},"physDesc":[{"extent":"6 S."}],"relHost":[{"pubHistory":["1.1915 -"],"titleAlt":[{"title":"PNAS online"},{"title":"PNAS"}],"part":{"pages":"2172-2177","issue":"7","year":"2006","extent":"6","volume":"103","text":"103(2006), 7, Seite 2172-2177"},"note":["Gesehen am 09.03.2022"],"disp":"National Academy of Sciences (Washington, DC)Proceedings of the National Academy of Sciences of the United States of America","type":{"media":"Online-Ressource","bibl":"periodical"},"corporate":[{"display":"National Academy of Sciences","roleDisplay":"VerfasserIn","role":"aut"}],"language":["eng"],"recId":"254235379","title":[{"title_sort":"Proceedings of the National Academy of Sciences of the United States of America","title":"Proceedings of the National Academy of Sciences of the United States of America"}],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisherPlace":"Washington, DC","dateIssuedDisp":"1915-","dateIssuedKey":"1915","publisher":"National Acad. of Sciences"}],"id":{"eki":["254235379"],"zdb":["1461794-8"],"issn":["1091-6490"]}}]} | ||
| SRT | |a DEVOSDAMIESIMPLEFOLD1420 | ||