Cover Image

Targeted localization of Inn1, Cyk3 and Chs2 by the mitotic-exit network regulates cytokinesis in budding yeast

The mitotic-exit network (MEN) is a signaling pathway that is essential for the coordination of mitotic exit and cytokinesis. Whereas the role of the MEN in mitotic exit is well established, the molecular mechanisms by which MEN components regulate cytokinesis remain poorly understood. Here, we show...

Full description

Saved in:
Bibliographic Details
Main Authors: Meitinger, Franz (Author) , Pereira, Gislene (Author)
Format: Article (Journal)
Language:English
Published: May 19, 2010
In: Journal of cell science
Year: 2010, Volume: 123, Issue: 11, Pages: 1851-1861
ISSN:1477-9137
DOI:10.1242/jcs.063891
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1242/jcs.063891
Verlag, kostenfrei, Volltext: http://jcs.biologists.org/content/123/11/1851
Get full text
Author Notes:Franz Meitinger, Boryana Petrova, Ilde Mancini Lombardi, Daniela Trinca Bertazzi, Birgit Hub, Hanswalter Zentgraf and Gislene Pereira

MARC

LEADER 00000caa a2200000 c 4500
001 1558639543
003 DE-627
005 20220813172537.0
007 cr uuu---uuuuu
008 170516s2010 xx |||||o 00| ||eng c
024 7 |a 10.1242/jcs.063891  |2 doi 
035 |a (DE-627)1558639543 
035 |a (DE-576)488639549 
035 |a (DE-599)BSZ488639549 
035 |a (OCoLC)1340975323 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 32  |2 sdnb 
100 1 |a Meitinger, Franz  |e VerfasserIn  |0 (DE-588)113182539X  |0 (DE-627)886618061  |0 (DE-576)48851794X  |4 aut 
245 1 0 |a Targeted localization of Inn1, Cyk3 and Chs2 by the mitotic-exit network regulates cytokinesis in budding yeast  |c Franz Meitinger, Boryana Petrova, Ilde Mancini Lombardi, Daniela Trinca Bertazzi, Birgit Hub, Hanswalter Zentgraf and Gislene Pereira 
264 1 |c May 19, 2010 
300 |a 11 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 16.05.2017 
520 |a The mitotic-exit network (MEN) is a signaling pathway that is essential for the coordination of mitotic exit and cytokinesis. Whereas the role of the MEN in mitotic exit is well established, the molecular mechanisms by which MEN components regulate cytokinesis remain poorly understood. Here, we show that the MEN controls components involved in septum formation, including Inn1, Cyk3 and Chs2. MEN-deficient mutants, forced to exit mitosis as a result of Cdk1 inactivation, show defects in targeting Cyk3 and Inn1 to the bud-neck region. In addition, we found that the chitin synthase Chs2 did not efficiently localize at the bud neck in the absence of MEN activity. Ultrastructural analysis of the bud neck revealed that low MEN activity led to unilateral, uncoordinated extension of the primary and secondary septa. This defect was partially suppressed by increased levels of Cyk3. We therefore propose that the MEN directly controls cytokinesis via targeting of Inn1, Cyk3 and Chs2 to the bud neck. 
700 1 |a Pereira, Gislene  |e VerfasserIn  |0 (DE-588)1131901568  |0 (DE-627)886950988  |0 (DE-576)488570433  |4 aut 
773 0 8 |i Enthalten in  |t Journal of cell science  |d Cambridge : Company of Biologists Limited, 1853  |g 123(2010), 11, Seite 1851-1861  |h Online-Ressource  |w (DE-627)300595433  |w (DE-600)1483099-1  |w (DE-576)090854837  |x 1477-9137  |7 nnas  |a Targeted localization of Inn1, Cyk3 and Chs2 by the mitotic-exit network regulates cytokinesis in budding yeast 
773 1 8 |g volume:123  |g year:2010  |g number:11  |g pages:1851-1861  |g extent:11  |a Targeted localization of Inn1, Cyk3 and Chs2 by the mitotic-exit network regulates cytokinesis in budding yeast 
856 4 0 |u http://dx.doi.org/10.1242/jcs.063891  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u http://jcs.biologists.org/content/123/11/1851  |x Verlag  |z kostenfrei  |3 Volltext 
951 |a AR 
992 |a 20170516 
993 |a Article 
994 |a 2010 
998 |g 1131901568  |a Pereira, Gislene  |m 1131901568:Pereira, Gislene  |p 7  |y j 
998 |g 113182539X  |a Meitinger, Franz  |m 113182539X:Meitinger, Franz  |p 1  |x j 
999 |a KXP-PPN1558639543  |e 2969494302 
BIB |a Y 
SER |a journal 
JSO |a {"origin":[{"dateIssuedDisp":"May 19, 2010","dateIssuedKey":"2010"}],"id":{"doi":["10.1242/jcs.063891"],"eki":["1558639543"]},"name":{"displayForm":["Franz Meitinger, Boryana Petrova, Ilde Mancini Lombardi, Daniela Trinca Bertazzi, Birgit Hub, Hanswalter Zentgraf and Gislene Pereira"]},"physDesc":[{"extent":"11 S."}],"relHost":[{"titleAlt":[{"title":"Quarterly journal of microscopical science"}],"part":{"year":"2010","pages":"1851-1861","issue":"11","text":"123(2010), 11, Seite 1851-1861","volume":"123","extent":"11"},"pubHistory":["1.1853 - 8.1860; N.S. 1.1861 - 87.1946; 3.Ser. 88.1947 - 106.1965; 1.1966 -"],"corporate":[{"role":"isb","display":"The Company of Biologists","roleDisplay":"Herausgebendes Organ"}],"language":["eng"],"recId":"300595433","type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Targeted localization of Inn1, Cyk3 and Chs2 by the mitotic-exit network regulates cytokinesis in budding yeastJournal of cell science","note":["Gesehen am 22.04.2021"],"title":[{"subtitle":"Company of Biologists","title":"Journal of cell science","title_sort":"Journal of cell science"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["1483099-1"],"eki":["300595433"],"issn":["1477-9137"]},"origin":[{"dateIssuedDisp":"1853-","dateIssuedKey":"1853","publisher":"Company of Biologists Limited","publisherPlace":"Cambridge"}]}],"title":[{"title_sort":"Targeted localization of Inn1, Cyk3 and Chs2 by the mitotic-exit network regulates cytokinesis in budding yeast","title":"Targeted localization of Inn1, Cyk3 and Chs2 by the mitotic-exit network regulates cytokinesis in budding yeast"}],"person":[{"given":"Franz","family":"Meitinger","role":"aut","display":"Meitinger, Franz","roleDisplay":"VerfasserIn"},{"given":"Gislene","family":"Pereira","role":"aut","roleDisplay":"VerfasserIn","display":"Pereira, Gislene"}],"note":["Gesehen am 16.05.2017"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"recId":"1558639543","language":["eng"]} 
SRT |a MEITINGERFTARGETEDLO1920 

Similar Items