Simplification of biochemical models: a general approach based on the analysis of the impact of individual species and reactions on the systems dynamics

Given the complex mechanisms underlying biochemical processes systems biology researchers tend to build ever increasing computational models. However, dealing with complex systems entails a variety of problems, e.g. difficult intuitive understanding, variety of time scales or non-identifiable parame...

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Hauptverfasser:	Surovtsova, Irina (VerfasserIn) , Simus, Natalia (VerfasserIn) , Hübner, Katrin (VerfasserIn) , Sahle, Sven (VerfasserIn) , Kummer, Ursula (VerfasserIn)
Dokumenttyp:	Article (Journal)
Sprache:	Englisch
Veröffentlicht:	2012
In:	BMC systems biology Year: 2012, Jahrgang: 6, Pages: ?
ISSN:	1752-0509
DOI:	10.1186/1752-0509-6-14
Online-Zugang:	Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/1752-0509-6-14
Verfasserangaben:	Irina Surovtsova, Natalia Simus, Katrin Hübner, Sven Sahle and Ursula Kummer

Simplification of biochemical models: a general approach based on the analysis of the impact of individual species and reactions on the systems dynamics von Surovtsova, Irina (VerfasserIn) , Simus, Natalia (VerfasserIn) , Hübner, Katrin (VerfasserIn) , Sahle, Sven (VerfasserIn) , Kummer, Ursula (VerfasserIn) ,

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Simplification of biochemical models: a general approach based on the analysis of the impact of individual species and reactions on the systems dynamics

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