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Simplification of biochemical models: a general approach based on the analysis of the impact of individual species and reactions on the systems dynamics

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Given the complex mechanisms underlying biochemical processes systems biology researchers tend to build ever increasing computational models. However, dealing with complex systems entails a variety of problems, e.g. difficult intuitive understanding, variety of time scales or non-identifiable parame...

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Main Authors: Surovtsova, Irina (Author) , Simus, Natalia (Author) , Hübner, Katrin (Author) , Sahle, Sven (Author) , Kummer, Ursula (Author)
Format: Article (Journal)
Language:English
Published: 2012
In: BMC systems biology
Year: 2012, Volume: 6, Pages: ?
ISSN:1752-0509
DOI:10.1186/1752-0509-6-14
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/1752-0509-6-14
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Author Notes:Irina Surovtsova, Natalia Simus, Katrin Hübner, Sven Sahle and Ursula Kummer
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Simplification of biochemical models: a general approach based on the analysis of the impact of individual species and reactions on the systems dynamics by Surovtsova, Irina (Author) , Simus, Natalia (Author) , Hübner, Katrin (Author) , Sahle, Sven (Author) , Kummer, Ursula (Author) ,

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