Does the addition of cetuximab to radiochemotherapy improve outcome of patients with locally advanced rectal cancer?: long-term results from phase II trials
Purpose. The addition of cetuximab to radiochemotherapy (RCT) failed to improve complete response rates in locally advanced rectal cancer (LARC). We report the long-term results in patients treated within two sequential clinical trials. Methods. Patients receiving neoadjuvant RCT using capecitabine...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2015
|
| In: |
Gastroenterology research and practice
|
| ISSN: | 1687-630X |
| DOI: | 10.1155/2015/273489 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1155/2015/273489 Verlag, kostenfrei, Volltext: https://www.hindawi.com/journals/grp/2015/273489/abs/ 
|
| Verfasserangaben: | M. Kripp, K. Horisberger, S. Mai, P. Kienle, T. Gaiser, S. Post, F. Wenz, K. Merx, R.-D. Hofheinz |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1559189525 | ||
| 003 | DE-627 | ||
| 005 | 20230428071204.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 170531s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1155/2015/273489 |2 doi | |
| 035 | |a (DE-627)1559189525 | ||
| 035 | |a (DE-576)489189520 | ||
| 035 | |a (DE-599)BSZ489189520 | ||
| 035 | |a (OCoLC)1340975891 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Kripp, Melanie |d 1978- |e VerfasserIn |0 (DE-588)133370925 |0 (DE-627)544030133 |0 (DE-576)299802183 |4 aut | |
| 245 | 1 | 0 | |a Does the addition of cetuximab to radiochemotherapy improve outcome of patients with locally advanced rectal cancer? |b long-term results from phase II trials |c M. Kripp, K. Horisberger, S. Mai, P. Kienle, T. Gaiser, S. Post, F. Wenz, K. Merx, R.-D. Hofheinz |
| 264 | 1 | |c 2015 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 31.05.2017 | ||
| 520 | |a Purpose. The addition of cetuximab to radiochemotherapy (RCT) failed to improve complete response rates in locally advanced rectal cancer (LARC). We report the long-term results in patients treated within two sequential clinical trials. Methods. Patients receiving neoadjuvant RCT using capecitabine and irinotecan (CapIri) within a phase I/II trial or CapIri + cetuximab within a phase II trial were evaluated for analysis of disease-free survival (DFS) and overall survival (OS). KRAS exon 2 mutational status had been analyzed in patients receiving cetuximab. Results. 37 patients from the CapIri trial and 49 patients from the CapIri-cetuximab treatment group were evaluable. Median follow-up time was 75.2 months. The 5-year DFS rate was 82% (CapIri) and 79% (CapIri-cetuximab) . The median OS was 127.4 months. 5-year OS was 73% for both groups (CapIri and CapIri-cetuximab) . No significant difference in DFS or OS was noticed between patients receiving CapIri and those receiving CapIri-cetuximab with KRAS wild-type tumors. Conclusions. As the addition of cetuximab did not improve neither DFS nor OS it should not play a role in the perioperative treatment of patients with LARC, not even of patients with (K)RAS WT tumors. | ||
| 700 | 1 | |a Horisberger, Karoline |d 1974- |e VerfasserIn |0 (DE-588)129014850 |0 (DE-627)387770240 |0 (DE-576)297447602 |4 aut | |
| 700 | 1 | |a Mai, Sabine |d 1964- |e VerfasserIn |0 (DE-588)1048197883 |0 (DE-627)779968042 |0 (DE-576)402013913 |4 aut | |
| 700 | 1 | |a Kienle, Peter |d 1966- |e VerfasserIn |0 (DE-588)1030310262 |0 (DE-627)735023476 |0 (DE-576)378115898 |4 aut | |
| 700 | 1 | |a Gaiser, Timo |d 1975- |e VerfasserIn |0 (DE-588)1030402280 |0 (DE-627)735221685 |0 (DE-576)378226533 |4 aut | |
| 700 | 1 | |a Post, Stefan |d 1954- |e VerfasserIn |0 (DE-588)1026227518 |0 (DE-627)726294667 |0 (DE-576)371524598 |4 aut | |
| 700 | 1 | |a Wenz, Frederik |d 1966- |e VerfasserIn |0 (DE-588)113310390 |0 (DE-627)663837766 |0 (DE-576)346656281 |4 aut | |
| 700 | 1 | |a Merx, Kirsten |d 1970- |e VerfasserIn |0 (DE-588)122413091 |0 (DE-627)70589892X |0 (DE-576)293258910 |4 aut | |
| 700 | 1 | |a Hofheinz, Ralf-Dieter |d 1969- |e VerfasserIn |0 (DE-588)121917517 |0 (DE-627)08161876X |0 (DE-576)292991568 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Gastroenterology research and practice |d [Hoboken, NJ : Wiley], 2008 |g (2015) Artikel-Nummer e273489, 9 Seiten |h Online-Ressource |w (DE-627)571608647 |w (DE-600)2435460-0 |w (DE-576)283869534 |x 1687-630X |7 nnas |a Does the addition of cetuximab to radiochemotherapy improve outcome of patients with locally advanced rectal cancer? long-term results from phase II trials |
| 773 | 1 | 8 | |g year:2015 |g extent:9 |a Does the addition of cetuximab to radiochemotherapy improve outcome of patients with locally advanced rectal cancer? long-term results from phase II trials |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1155/2015/273489 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.hindawi.com/journals/grp/2015/273489/abs/ |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20170531 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 121917517 |a Hofheinz, Ralf-Dieter |m 121917517:Hofheinz, Ralf-Dieter |d 60000 |d 65500 |e 60000PH121917517 |e 65500PH121917517 |k 0/60000/ |k 1/60000/65500/ |p 9 |y j | ||
| 998 | |g 122413091 |a Merx, Kirsten |m 122413091:Merx, Kirsten |d 60000 |d 61200 |e 60000PM122413091 |e 61200PM122413091 |k 0/60000/ |k 1/60000/61200/ |p 8 | ||
| 998 | |g 113310390 |a Wenz, Frederik |m 113310390:Wenz, Frederik |d 60000 |d 63000 |e 60000PW113310390 |e 63000PW113310390 |k 0/60000/ |k 1/60000/63000/ |p 7 | ||
| 998 | |g 1026227518 |a Post, Stefan |m 1026227518:Post, Stefan |d 60000 |d 61800 |e 60000PP1026227518 |e 61800PP1026227518 |k 0/60000/ |k 1/60000/61800/ |p 6 | ||
| 998 | |g 1030402280 |a Gaiser, Timo |m 1030402280:Gaiser, Timo |d 60000 |d 63400 |e 60000PG1030402280 |e 63400PG1030402280 |k 0/60000/ |k 1/60000/63400/ |p 5 | ||
| 998 | |g 1030310262 |a Kienle, Peter |m 1030310262:Kienle, Peter |d 60000 |d 50000 |e 60000PK1030310262 |e 50000PK1030310262 |k 0/60000/ |k 0/50000/ |p 4 | ||
| 998 | |g 1048197883 |a Mai, Sabine |m 1048197883:Mai, Sabine |d 60000 |d 63000 |e 60000PM1048197883 |e 63000PM1048197883 |k 0/60000/ |k 1/60000/63000/ |p 3 | ||
| 998 | |g 129014850 |a Horisberger, Karoline |m 129014850:Horisberger, Karoline |d 60000 |d 61800 |e 60000PH129014850 |e 61800PH129014850 |k 0/60000/ |k 1/60000/61800/ |p 2 | ||
| 998 | |g 133370925 |a Kripp, Melanie |m 133370925:Kripp, Melanie |d 60000 |d 61200 |e 60000PK133370925 |e 61200PK133370925 |k 0/60000/ |k 1/60000/61200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1559189525 |e 2970548496 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2015","dateIssuedDisp":"2015"}],"recId":"1559189525","type":{"bibl":"article-journal","media":"Online-Ressource"},"physDesc":[{"extent":"9 S."}],"id":{"doi":["10.1155/2015/273489"],"eki":["1559189525"]},"relHost":[{"title":[{"title":"Gastroenterology research and practice","title_sort":"Gastroenterology research and practice"}],"part":{"year":"2015","text":"(2015) Artikel-Nummer e273489, 9 Seiten","extent":"9"},"language":["eng"],"pubHistory":["1.2008 -"],"disp":"Does the addition of cetuximab to radiochemotherapy improve outcome of patients with locally advanced rectal cancer? long-term results from phase II trialsGastroenterology research and practice","id":{"eki":["571608647"],"issn":["1687-630X"],"zdb":["2435460-0"],"doi":["10.1155/GRP"]},"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 27.07.2021"],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"571608647","origin":[{"publisherPlace":"[Hoboken, NJ ; New York, NY","publisher":"Wiley] ; Hindawi","dateIssuedDisp":"2024-","dateIssuedKey":"2024"}]}],"note":["Gesehen am 31.05.2017"],"name":{"displayForm":["M. Kripp, K. Horisberger, S. Mai, P. Kienle, T. Gaiser, S. Post, F. Wenz, K. Merx, R.-D. Hofheinz"]},"person":[{"family":"Kripp","role":"aut","given":"Melanie","display":"Kripp, Melanie"},{"family":"Horisberger","display":"Horisberger, Karoline","given":"Karoline","role":"aut"},{"family":"Mai","display":"Mai, Sabine","role":"aut","given":"Sabine"},{"family":"Kienle","role":"aut","given":"Peter","display":"Kienle, Peter"},{"display":"Gaiser, Timo","given":"Timo","role":"aut","family":"Gaiser"},{"role":"aut","given":"Stefan","display":"Post, Stefan","family":"Post"},{"family":"Wenz","display":"Wenz, Frederik","role":"aut","given":"Frederik"},{"given":"Kirsten","role":"aut","display":"Merx, Kirsten","family":"Merx"},{"role":"aut","given":"Ralf-Dieter","display":"Hofheinz, Ralf-Dieter","family":"Hofheinz"}],"title":[{"subtitle":"long-term results from phase II trials","title":"Does the addition of cetuximab to radiochemotherapy improve outcome of patients with locally advanced rectal cancer?","title_sort":"Does the addition of cetuximab to radiochemotherapy improve outcome of patients with locally advanced rectal cancer?"}],"language":["eng"]} | ||
| SRT | |a KRIPPMELANDOESTHEADD2015 | ||