Glucagon-like peptide-1 receptor is involved in learning and neuroprotection
Glucagon-like peptide-1 (GLP-1) is a gut peptide that, together with its receptor, GLP-1R, is expressed in the brain. Here we show that intracerebroventricular (i.c.v.) GLP-1 and [Ser(2)]exendin(1−9) (HSEGTFTSD; homologous to a conserved domain in the glucagon/GLP-1 family) enhance associative and s...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
17 August 2003
|
| In: |
Nature medicine
Year: 2003, Jahrgang: 9, Heft: 9, Pages: 1173-1179 |
| ISSN: | 1546-170X |
| DOI: | 10.1038/nm919 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1038/nm919 Verlag, Volltext: http://www.nature.com/nm/journal/v9/n9/full/nm919.html 
|
| Verfasserangaben: | Matthew J. During, Lei Cao, David S. Zuzga, Jeremy S. Francis, Helen L. Fitzsimons, Xiangyang Jiao, Ross J. Bland, Matthias Klugmann, William A. Banks, Daniel J. Drucker, Colin N. Haile |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1559635819 | ||
| 003 | DE-627 | ||
| 005 | 20230428071223.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 170609s2003 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/nm919 |2 doi | |
| 035 | |a (DE-627)1559635819 | ||
| 035 | |a (DE-576)489635814 | ||
| 035 | |a (DE-599)BSZ489635814 | ||
| 035 | |a (OCoLC)1340976055 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a During, Matthew J. |e VerfasserIn |4 aut | |
| 245 | 1 | 0 | |a Glucagon-like peptide-1 receptor is involved in learning and neuroprotection |c Matthew J. During, Lei Cao, David S. Zuzga, Jeremy S. Francis, Helen L. Fitzsimons, Xiangyang Jiao, Ross J. Bland, Matthias Klugmann, William A. Banks, Daniel J. Drucker, Colin N. Haile |
| 264 | 1 | |c 17 August 2003 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 08.06.2017 | ||
| 520 | |a Glucagon-like peptide-1 (GLP-1) is a gut peptide that, together with its receptor, GLP-1R, is expressed in the brain. Here we show that intracerebroventricular (i.c.v.) GLP-1 and [Ser(2)]exendin(1−9) (HSEGTFTSD; homologous to a conserved domain in the glucagon/GLP-1 family) enhance associative and spatial learning through GLP-1R. [Ser(2)]exendin(1−9), but not GLP-1, is also active when administered peripherally. GLP-1R-deficient mice have a phenotype characterized by a learning deficit that is restored after hippocampal Glp1r gene transfer. In addition, rats overexpressing GLP-1R in the hippocampus show improved learning and memory. GLP-1R-deficient mice also have enhanced seizure severity and neuronal injury after kainate administration, with an intermediate phenotype in heterozygotes and phenotypic correction after Glp1r gene transfer in hippocampal somatic cells. Systemic administration of [Ser(2)]exendin(1−9) in wild-type animals prevents kainate-induced apoptosis of hippocampal neurons. Brain GLP-1R represents a promising new target for both cognitive-enhancing and neuroprotective agents. | ||
| 700 | 1 | |a Klugmann, Matthias |e VerfasserIn |0 (DE-588)1133043976 |0 (DE-627)888192622 |0 (DE-576)489077609 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature medicine |d [New York, NY] : Springer Nature, 1995 |g 9(2003), 9, Seite 1173-1179 |h Online-Ressource |w (DE-627)301511640 |w (DE-600)1484517-9 |w (DE-576)288571274 |x 1546-170X |7 nnas |a Glucagon-like peptide-1 receptor is involved in learning and neuroprotection |
| 773 | 1 | 8 | |g volume:9 |g year:2003 |g number:9 |g pages:1173-1179 |g extent:7 |a Glucagon-like peptide-1 receptor is involved in learning and neuroprotection |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/nm919 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.nature.com/nm/journal/v9/n9/full/nm919.html |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20170609 | ||
| 993 | |a Article | ||
| 994 | |a 2003 | ||
| 998 | |g 1133043976 |a Klugmann, Matthias |m 1133043976:Klugmann, Matthias | ||
| 999 | |a KXP-PPN1559635819 |e 2971737780 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"7 S."}],"relHost":[{"origin":[{"publisherPlace":"[New York, NY] ; New York, NY","dateIssuedDisp":"2017-","publisher":"Springer Nature ; Nature America Inc.","dateIssuedKey":"2017"}],"id":{"zdb":["1484517-9"],"eki":["301511640"],"issn":["1546-170X"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Nature medicine","title":"Nature medicine"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 24. Juli 2018"],"disp":"Glucagon-like peptide-1 receptor is involved in learning and neuroprotectionNature medicine","recId":"301511640","language":["eng"],"pubHistory":["1.1995 -"],"part":{"year":"2003","issue":"9","pages":"1173-1179","volume":"9","text":"9(2003), 9, Seite 1173-1179","extent":"7"}}],"name":{"displayForm":["Matthew J. During, Lei Cao, David S. Zuzga, Jeremy S. Francis, Helen L. Fitzsimons, Xiangyang Jiao, Ross J. Bland, Matthias Klugmann, William A. Banks, Daniel J. Drucker, Colin N. Haile"]},"origin":[{"dateIssuedDisp":"17 August 2003","dateIssuedKey":"2003"}],"id":{"eki":["1559635819"],"doi":["10.1038/nm919"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 08.06.2017"],"language":["eng"],"recId":"1559635819","person":[{"given":"Matthew J.","family":"During","role":"aut","display":"During, Matthew J.","roleDisplay":"VerfasserIn"},{"given":"Matthias","family":"Klugmann","role":"aut","roleDisplay":"VerfasserIn","display":"Klugmann, Matthias"}],"title":[{"title":"Glucagon-like peptide-1 receptor is involved in learning and neuroprotection","title_sort":"Glucagon-like peptide-1 receptor is involved in learning and neuroprotection"}]} | ||
| SRT | |a DURINGMATTGLUCAGONLI1720 | ||