Monoclonal antibody detects oligodendroglial cell surface protein exhibiting temporal regulation during development
As tools to study stage-specific surface molecules expressed during the development of oligodendrocytes, we have generated monoclonal antibodies against peanut agglutinin (PNA)-binding glycoproteins isolated by affinity chromatography from the oligodendroglial precursor cell line Oli-neu. In this pa...
Gespeichert in:
| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
22 October 1999
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| In: |
Glia
Year: 1999, Jahrgang: 28, Heft: 2, Pages: 128-137$p10 |
| ISSN: | 1098-1136 |
| DOI: | 10.1002/(SICI)1098-1136(199911)28:2<128::AID-GLIA4>3.0.CO;2-E |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1002/(SICI)1098-1136(199911)28:2<128::AID-GLIA4>3.0.CO;2-E Verlag, Volltext: http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1098-1136(199911)28:2<128::AID-GLIA4>3.0.CO;2-E/abstract 
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| Verfasserangaben: | Martina Grzenkowski, Antje Niehaus, Jacqueline Trotter |
MARC
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| 520 | |a As tools to study stage-specific surface molecules expressed during the development of oligodendrocytes, we have generated monoclonal antibodies against peanut agglutinin (PNA)-binding glycoproteins isolated by affinity chromatography from the oligodendroglial precursor cell line Oli-neu. In this paper we report the characterization of the monoclonal antibody 7D10. The 7D10 antibody recognizes a 145-kD cell surface glycoprotein expressed by postmitotic multibranched cells of the oligodendroglial lineage. The antigen stains subpopulations of myelin-associated glycoprotein (MAG) and O4-positive cells and is subsequently down-regulated during further differentiation in vitro. The 7D10 antigen is also expressed by a subpopulation of astroglial cells but not by neurons. A truncated form of the protein is released by antigen-expressing cells into the culture supernatant. | ||
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