Trends in autologous hematopoietic cell transplantation for multiple myeloma in Europe: increased use and improved outcomes in elderly patients in recent years
Autologous hematopoietic cell transplantation (AHCT) is a standard of care in multiple myeloma (MM) patients aged <65 years. To understand age-related trends in utilisation and outcome of AHCT, we analysed 53 675 MM patients who underwent a first AHCT in 31 European countries between 1991 and 201...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2015
|
| In: |
Bone marrow transplantation
Year: 2014, Volume: 50, Issue: 2, Pages: 209-215 |
| ISSN: | 1476-5365 |
| DOI: | 10.1038/bmt.2014.255 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1038/bmt.2014.255 Verlag, Volltext: http://www.redi-bw.de/db/ebsco.php/search.ebscohost.com/login.aspx%3fdirect%3dtrue%26db%3da9h%26AN%3d100775159%26lang%3dde%26site%3deds-live 
|
| Author Notes: | H.W. Auner, R. Szydlo, J. Hoek, H. Goldschmidt, A.M. Stoppa, G.J. Morgan, P. Moreau, M. Attal, G. Marit, N. Russell, M. Brune, G. Cook, P. Sonneveld, S. Schönland, L. Garderet, and N. Kröger |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1560109629 | ||
| 003 | DE-627 | ||
| 005 | 20230428071246.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 170622r20152014xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/bmt.2014.255 |2 doi | |
| 035 | |a (DE-627)1560109629 | ||
| 035 | |a (DE-576)490109624 | ||
| 035 | |a (DE-599)BSZ490109624 | ||
| 035 | |a (OCoLC)1340975798 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Auner, Holger |e VerfasserIn |0 (DE-588)1135752621 |0 (DE-627)890794626 |0 (DE-576)490109012 |4 aut | |
| 245 | 1 | 0 | |a Trends in autologous hematopoietic cell transplantation for multiple myeloma in Europe |b increased use and improved outcomes in elderly patients in recent years |c H.W. Auner, R. Szydlo, J. Hoek, H. Goldschmidt, A.M. Stoppa, G.J. Morgan, P. Moreau, M. Attal, G. Marit, N. Russell, M. Brune, G. Cook, P. Sonneveld, S. Schönland, L. Garderet, and N. Kröger |
| 264 | 1 | |c 2015 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published online: 10 November 2014 | ||
| 500 | |a Gesehen am 22.06.2017 | ||
| 520 | |a Autologous hematopoietic cell transplantation (AHCT) is a standard of care in multiple myeloma (MM) patients aged <65 years. To understand age-related trends in utilisation and outcome of AHCT, we analysed 53 675 MM patients who underwent a first AHCT in 31 European countries between 1991 and 2010. The number of patients undergoing AHCT increased for all age groups (<40, 40-49, 50-59, 60-64, 65-69 and ⩾70 years) throughout the observation period. The highest increase was observed for patients aged ⩾65 years, who accounted for 3% of AHCTs in 1991-1995 and for 18.8% of AHCTs in 2006-2010. Risk factors associated with survival over the entire observation period (P<0.001) were calendar period, remission status at AHCT, gender, disease duration before AHCT and age. Survival improved considerably more in older than in younger patients in recent years. In 2006-2010, median 2- and 5-year post-transplant survival ranged from 85.9 and 61.5% in patients <40 years to 80.2 and 49.7% in those ⩾70 years. All-cause day-100 mortality decreased throughout the observation period to ⩽2.4% for all age groups in 2006-2010. The results of this study demonstrate increased utilisation and safety of AHCT with improved post-transplant survival particularly in elderly MM patients in recent years in Europe. | ||
| 534 | |c 2014 | ||
| 650 | 4 | |a DISEASE risk factors | |
| 650 | 4 | |a DISEASES in older people | |
| 650 | 4 | |a EUROPE | |
| 650 | 4 | |a HEMATOPOIETIC stem cell transplantation | |
| 650 | 4 | |a MULTIPLE myeloma treatment | |
| 650 | 4 | |a OUTCOME assessment (Medical care) | |
| 700 | 1 | |a Goldschmidt, Hartmut |d 1956- |e VerfasserIn |0 (DE-588)102258023X |0 (DE-627)717003809 |0 (DE-576)365637386 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Bone marrow transplantation |d London : Springer Nature, 1997 |g 50(2015), 2, Seite 209-215 |h Online-Ressource |w (DE-627)320433366 |w (DE-600)2004030-1 |w (DE-576)091012996 |x 1476-5365 |7 nnas |a Trends in autologous hematopoietic cell transplantation for multiple myeloma in Europe increased use and improved outcomes in elderly patients in recent years |
| 773 | 1 | 8 | |g volume:50 |g year:2015 |g number:2 |g pages:209-215 |g extent:7 |a Trends in autologous hematopoietic cell transplantation for multiple myeloma in Europe increased use and improved outcomes in elderly patients in recent years |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/bmt.2014.255 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.redi-bw.de/db/ebsco.php/search.ebscohost.com/login.aspx%3fdirect%3dtrue%26db%3da9h%26AN%3d100775159%26lang%3dde%26site%3deds-live |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20170622 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 102258023X |a Goldschmidt, Hartmut |m 102258023X:Goldschmidt, Hartmut |d 910000 |d 910100 |e 910000PG102258023X |e 910100PG102258023X |k 0/910000/ |k 1/910000/910100/ |p 4 | ||
| 999 | |a KXP-PPN1560109629 |e 297232983X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"display":"Auner, Holger","family":"Auner","role":"aut","given":"Holger"},{"family":"Goldschmidt","display":"Goldschmidt, Hartmut","role":"aut","given":"Hartmut"}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title":"Trends in autologous hematopoietic cell transplantation for multiple myeloma in Europe","subtitle":"increased use and improved outcomes in elderly patients in recent years","title_sort":"Trends in autologous hematopoietic cell transplantation for multiple myeloma in Europe"}],"note":["Published online: 10 November 2014","Gesehen am 22.06.2017"],"origin":[{"dateIssuedKey":"2015","dateIssuedDisp":"2015"}],"id":{"eki":["1560109629"],"doi":["10.1038/bmt.2014.255"]},"recId":"1560109629","relHost":[{"part":{"issue":"2","text":"50(2015), 2, Seite 209-215","pages":"209-215","year":"2015","extent":"7","volume":"50"},"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Trends in autologous hematopoietic cell transplantation for multiple myeloma in Europe increased use and improved outcomes in elderly patients in recent yearsBone marrow transplantation","note":["Gesehen am 17.01.25"],"origin":[{"dateIssuedDisp":"1997-","dateIssuedKey":"1997","publisher":"Springer Nature ; Macmillan ; Nature Publishing Group","publisherPlace":"London ; Basingstoke ; London"}],"pubHistory":["Nachgewiesen 19.1997 -"],"title":[{"title_sort":"Bone marrow transplantation","title":"Bone marrow transplantation"}],"id":{"zdb":["2004030-1"],"issn":["1476-5365"],"eki":["320433366"]},"recId":"320433366","physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"extent":"7 S."}],"name":{"displayForm":["H.W. Auner, R. Szydlo, J. Hoek, H. Goldschmidt, A.M. Stoppa, G.J. Morgan, P. Moreau, M. Attal, G. Marit, N. Russell, M. Brune, G. Cook, P. Sonneveld, S. Schönland, L. Garderet, and N. Kröger"]}} | ||
| SRT | |a AUNERHOLGETRENDSINAU2015 | ||