Erp1/Emi2 is essential for the meiosis I to meiosis II transition in Xenopus oocytes
Erp1 (also called Emi2), an inhibitor of the APC/C ubiquitin ligase, is a key component of cytostatic factor (CSF) responsible for Meta-II arrest in vertebrate eggs. Reportedly, however, Erp1 is expressed even during meiosis I in Xenopus oocytes. If so, it is a puzzle why normally maturing oocytes c...
Gespeichert in:
| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
3 November 2006
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| In: |
Developmental biology
Year: 2007, Jahrgang: 303, Heft: 1, Pages: 157-164 |
| ISSN: | 1095-564X |
| DOI: | 10.1016/j.ydbio.2006.10.044 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1016/j.ydbio.2006.10.044 Verlag, kostenfrei, Volltext: http://www.sciencedirect.com/science/article/pii/S0012160606013388 
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| Verfasserangaben: | Munemichi Ohe, Daigo Inoue, Yoshinori Kanemori, Noriyuki Sagata |
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| 520 | |a Erp1 (also called Emi2), an inhibitor of the APC/C ubiquitin ligase, is a key component of cytostatic factor (CSF) responsible for Meta-II arrest in vertebrate eggs. Reportedly, however, Erp1 is expressed even during meiosis I in Xenopus oocytes. If so, it is a puzzle why normally maturing oocytes cannot arrest at Meta-I. Here, we show that actually Erp1 synthesis begins only around the end of meiosis I in Xenopus oocytes, and that specific inhibition of Erp1 synthesis by morpholino oligos prevents entry into meiosis II. Furthermore, we demonstrate that premature, ectopic expression of Erp1 at physiological Meta-II levels can arrest maturing oocytes at Meta-I. Thus, our results show the essential role for Erp1 in the meiosis I/meiosis II transition in Xenopus oocytes and can explain why normally maturing oocytes cannot arrest at Meta-I. | ||
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