Review of potential improvements using MRI in the radiotherapy workflow
The goal of modern radiotherapy is to deliver a lethal amount of dose to tissue volumes that contain a significant amount of tumour cells while sparing surrounding unaffected or healthy tissue. Online image guided radiotherapy with stereotactic ultrasound, fiducial-based planar X-ray imaging or heli...
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2015
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| In: |
Zeitschrift für medizinische Physik
Year: 2015, Jahrgang: 25, Heft: 3, Pages: 210-220 |
| ISSN: | 1876-4436 |
| DOI: | 10.1016/j.zemedi.2014.11.003 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.zemedi.2014.11.003 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0939388914001469 
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| Verfasserangaben: | Alberto Torresin, Maria Grazia Brambilla, Angelo F. Monti, Alessio Moscato, Marc A. Brockmann, Lothar Schad, Ulrike I. Attenberger, Frank Lohr |
MARC
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| 245 | 1 | 0 | |a Review of potential improvements using MRI in the radiotherapy workflow |c Alberto Torresin, Maria Grazia Brambilla, Angelo F. Monti, Alessio Moscato, Marc A. Brockmann, Lothar Schad, Ulrike I. Attenberger, Frank Lohr |
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| 520 | |a The goal of modern radiotherapy is to deliver a lethal amount of dose to tissue volumes that contain a significant amount of tumour cells while sparing surrounding unaffected or healthy tissue. Online image guided radiotherapy with stereotactic ultrasound, fiducial-based planar X-ray imaging or helical/conebeam CT has dramatically improved the precision of radiotherapy, with moving targets still posing some methodical problems regarding positioning. Therefore, requirements for precise target delineation and identification of functional body structures to be spared by high doses become more evident. The identification of areas of relatively radioresistant cells or areas of high tumor cell density is currently under development. This review outlines the state of the art of MRI integration into treatment planning and its importance in follow up and the quantification of biological effects. Finally the current state of the art of online imaging for patient positioning will be outlined and indications will be given what the potential of integrated radiotherapy/online MRI systems is. | ||
| 520 | |a Das Ziel der modernen Strahlentherapie ist es, tumorizide Strahlendosen auf neoplastische Gewebe zu applizieren, während nicht befallene Gewebe geschont werden sollen. Online-Bildführung mit stereotaktischem Ultraschall, planarem Röntgen unter Zuhilfenahme von röntgendichten Markern oder helikalem bzw. Cone-Beam-CT am Beschleuniger hat die Präzision der Strahlentherapie dramatisch verbessert, wobei bewegliche Ziele noch methodische Probleme aufwerfen. Die Ansprüche an Zielvolumendefinition und die Identifikation von funktionellen Einheiten, die möglichst geschont werden müssen, werden dadurch deutlicher. Die Identifikation von Tumorbereichen mit relativ strahlenresistenten Zellen bzw. hoher Tumorzelldichte ist gegenwärtig Forschungsgegenstand. Diese Arbeit soll einen Überblick über die Integration der MR-Bildgebung in die Strahlentherapieplanungskette geben sowie das Potenzial einer weiter reichenden Einbeziehung in den gesamten Strahlentherapie-Workflow umreißen. | ||
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| 650 | 4 | |a treatment planning | |
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