Expression of the novel hepatitis C virus Core+1/ARF protein in the context of JFH1-based replicons

Hepatitis C virus contains a second open reading frame within the core gene, designated core+1/ARF. Here we demonstrate for the first time expression of core+1/ARF protein in the context of a bicistronic JFH1-based replicon and report the production of two isoforms, core+1/L (long) and core+1/S (sho...

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Hauptverfasser: Kotta-Loizou, Ioly (VerfasserIn) , Bartenschlager, Ralf (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 18 February 2015
In: Journal of virology
Year: 2015, Jahrgang: 89, Heft: 9, Pages: 5164-5170
ISSN:1098-5514
DOI:10.1128/JVI.02351-14
Online-Zugang:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1128/JVI.02351-14
Verlag, kostenfrei, Volltext: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403472/
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Verfasserangaben:Ioly Kotta-Loizou, Ioannis Karakasiliotis, Niki Vassilaki, Panagiotis Sakellariou, Ralf Bartenschlager, Penelope Mavromara
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Zusammenfassung:Hepatitis C virus contains a second open reading frame within the core gene, designated core+1/ARF. Here we demonstrate for the first time expression of core+1/ARF protein in the context of a bicistronic JFH1-based replicon and report the production of two isoforms, core+1/L (long) and core+1/S (short), with different kinetics.
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Beschreibung:Online Resource
ISSN:1098-5514
DOI:10.1128/JVI.02351-14