Cover Image

Erythropoietin acts as an anti-inflammatory signal on murine mast cells

Recently it was found that the erythropoietin receptor (EpoR) is expressed on innate immune cells, such as dendritic cells and macrophages. We found that murine bone marrow-derived mast cells express the EpoR and that its expression is increased under hypoxic conditions. Interestingly, Epo stimulati...

Full description

Saved in:
Bibliographic Details
Main Authors: Wiedenmann, Tanja (Author) , Erhardt, Stefanie (Author) , Cerny, Daniela (Author) , Hildebrand, Dagmar (Author) , Klein, Sabrina (Author) , Heeg, Klaus (Author) , Hieke-Kubatzky, Katharina (Author)
Format: Article (Journal)
Language:English
Published: 30 January 2015
In: Molecular immunology
Year: 2015, Volume: 65, Issue: 1, Pages: 68-76
ISSN:1872-9142
DOI:10.1016/j.molimm.2015.01.011
Online Access:Verlag, Volltext: http://dx.doi.org/10.1016/j.molimm.2015.01.011
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0161589015000218
Get full text
Author Notes:Tanja Wiedenmann, Stefanie Ehrhardt, Daniela Cerny, Dagmar Hildebrand, Sabrina Klein, Klaus Heeg, Katharina F. Kubatzky

MARC

LEADER 00000caa a2200000 c 4500
001 1560568712
003 DE-627
005 20240415103413.0
007 cr uuu---uuuuu
008 170707s2015 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.molimm.2015.01.011  |2 doi 
035 |a (DE-627)1560568712 
035 |a (DE-576)490568718 
035 |a (DE-599)BSZ490568718 
035 |a (OCoLC)1340976784 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Wiedenmann, Tanja  |e VerfasserIn  |0 (DE-588)1115669516  |0 (DE-627)869867644  |0 (DE-576)477853021  |4 aut 
245 1 0 |a Erythropoietin acts as an anti-inflammatory signal on murine mast cells  |c Tanja Wiedenmann, Stefanie Ehrhardt, Daniela Cerny, Dagmar Hildebrand, Sabrina Klein, Klaus Heeg, Katharina F. Kubatzky 
264 1 |c 30 January 2015 
300 |a 9 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 07.07.2017 
520 |a Recently it was found that the erythropoietin receptor (EpoR) is expressed on innate immune cells, such as dendritic cells and macrophages. We found that murine bone marrow-derived mast cells express the EpoR and that its expression is increased under hypoxic conditions. Interestingly, Epo stimulation of the cells did not activate signal transducer and activator of transcription molecules, nor did we find differences in the expression of typical STAT-dependent genes, the proliferation rate, and the ability to differentiate or to protect the cells from apoptosis. Instead, we demonstrate that stimulation of mast cells with Epo leads to phosphorylation of the receptor tyrosine kinase c-kit. We hypothesize that this is due to the formation of a receptor complex between the EpoR and c-kit. The common beta chain of the IL-3 receptor family, which was described as part of the tissue protective receptor (TPR) on other non-erythroid cells, however is not activated. To investigate whether the EpoR/c-kit complex has tissue protective properties, cells were treated with the Toll-like receptor ligand LPS. Combined Epo and LPS treatment downregulated the inflammatory response of the cells as detected by a decrease in IL-6 and TNF-α secretion. 
650 4 |a Bone marrow-derived mast cells 
650 4 |a Erythropoietin 
650 4 |a Hypoxia 
650 4 |a Pro-inflammatory cytokines 
650 4 |a Stem cell factor receptor 
650 4 |a Toll-like receptor 
700 1 |a Erhardt, Stefanie  |e VerfasserIn  |0 (DE-588)1136575359  |0 (DE-627)893135593  |0 (DE-576)490656463  |4 aut 
700 1 |a Cerny, Daniela  |e VerfasserIn  |0 (DE-588)1070474991  |0 (DE-627)82390086X  |0 (DE-576)430061358  |4 aut 
700 1 |a Hildebrand, Dagmar  |d 1979-  |e VerfasserIn  |0 (DE-588)1013137892  |0 (DE-627)704967073  |0 (DE-576)346073596  |4 aut 
700 1 |a Klein, Sabrina  |d 1982-  |e VerfasserIn  |0 (DE-588)138788715  |0 (DE-627)703106554  |0 (DE-576)309063922  |4 aut 
700 1 |a Heeg, Klaus  |d 1956-  |e VerfasserIn  |0 (DE-588)133238369  |0 (DE-627)539308587  |0 (DE-576)299716805  |4 aut 
700 1 |a Hieke-Kubatzky, Katharina  |e VerfasserIn  |0 (DE-588)1070475114  |0 (DE-627)823900819  |0 (DE-576)430061307  |4 aut 
773 0 8 |i Enthalten in  |t Molecular immunology  |d Amsterdam [u.a.] : Elsevier, 1979  |g 65(2015), 1, Seite 68-76  |h Online-Ressource  |w (DE-627)320511332  |w (DE-600)2013448-4  |w (DE-576)252776437  |x 1872-9142  |7 nnas  |a Erythropoietin acts as an anti-inflammatory signal on murine mast cells 
773 1 8 |g volume:65  |g year:2015  |g number:1  |g pages:68-76  |g extent:9  |a Erythropoietin acts as an anti-inflammatory signal on murine mast cells 
856 4 0 |u http://dx.doi.org/10.1016/j.molimm.2015.01.011  |x Verlag  |x Resolving-System  |3 Volltext 
856 4 0 |u http://www.sciencedirect.com/science/article/pii/S0161589015000218  |x Verlag  |3 Volltext 
951 |a AR 
992 |a 20170707 
993 |a Article 
994 |a 2015 
998 |g 1070475114  |a Hieke-Kubatzky, Katharina  |m 1070475114:Hieke-Kubatzky, Katharina  |d 910000  |d 911700  |e 910000PH1070475114  |e 911700PH1070475114  |k 0/910000/  |k 1/910000/911700/  |p 7  |y j 
998 |g 133238369  |a Heeg, Klaus  |m 133238369:Heeg, Klaus  |d 910000  |d 911700  |e 910000PH133238369  |e 911700PH133238369  |k 0/910000/  |k 1/910000/911700/  |p 6 
998 |g 138788715  |a Klein, Sabrina  |m 138788715:Klein, Sabrina  |d 910000  |d 911700  |e 910000PK138788715  |e 911700PK138788715  |k 0/910000/  |k 1/910000/911700/  |p 5 
998 |g 1013137892  |a Hildebrand, Dagmar  |m 1013137892:Hildebrand, Dagmar  |d 910000  |d 911700  |e 910000PH1013137892  |e 911700PH1013137892  |k 0/910000/  |k 1/910000/911700/  |p 4 
998 |g 1070474991  |a Cerny, Daniela  |m 1070474991:Cerny, Daniela  |d 910000  |d 911700  |e 910000PC1070474991  |e 911700PC1070474991  |k 0/910000/  |k 1/910000/911700/  |p 3 
998 |g 1136575359  |a Ehrhardt, Stefanie  |m 1136575359:Ehrhardt, Stefanie  |d 910000  |d 911700  |e 910000PE1136575359  |e 911700PE1136575359  |k 0/910000/  |k 1/910000/911700/  |p 2 
998 |g 1115669516  |a Wiedenmann, Tanja  |m 1115669516:Wiedenmann, Tanja  |d 910000  |d 911700  |e 910000PW1115669516  |e 911700PW1115669516  |k 0/910000/  |k 1/910000/911700/  |p 1  |x j 
999 |a KXP-PPN1560568712  |e 2973310261 
BIB |a Y 
SER |a journal 
JSO |a {"person":[{"family":"Wiedenmann","display":"Wiedenmann, Tanja","role":"aut","given":"Tanja"},{"given":"Stefanie","display":"Erhardt, Stefanie","family":"Erhardt","role":"aut"},{"given":"Daniela","role":"aut","family":"Cerny","display":"Cerny, Daniela"},{"role":"aut","display":"Hildebrand, Dagmar","family":"Hildebrand","given":"Dagmar"},{"role":"aut","family":"Klein","display":"Klein, Sabrina","given":"Sabrina"},{"display":"Heeg, Klaus","family":"Heeg","role":"aut","given":"Klaus"},{"given":"Katharina","role":"aut","family":"Hieke-Kubatzky","display":"Hieke-Kubatzky, Katharina"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"relHost":[{"origin":[{"publisher":"Elsevier ; Pergamon Press","publisherPlace":"Amsterdam [u.a.] ; Oxford ; Frankfurt, M. [u.a.]","dateIssuedKey":"1979","dateIssuedDisp":"1979-"}],"id":{"issn":["1872-9142"],"eki":["320511332"],"zdb":["2013448-4"]},"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"title":[{"title_sort":"Molecular immunology","title":"Molecular immunology"}],"note":["Gesehen am 16.01.20"],"recId":"320511332","type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["16.1979 -"],"disp":"Erythropoietin acts as an anti-inflammatory signal on murine mast cellsMolecular immunology","part":{"pages":"68-76","volume":"65","extent":"9","issue":"1","year":"2015","text":"65(2015), 1, Seite 68-76"}}],"origin":[{"dateIssuedKey":"2015","dateIssuedDisp":"30 January 2015"}],"id":{"doi":["10.1016/j.molimm.2015.01.011"],"eki":["1560568712"]},"recId":"1560568712","title":[{"title":"Erythropoietin acts as an anti-inflammatory signal on murine mast cells","title_sort":"Erythropoietin acts as an anti-inflammatory signal on murine mast cells"}],"physDesc":[{"extent":"9 S."}],"language":["eng"],"note":["Gesehen am 07.07.2017"],"name":{"displayForm":["Tanja Wiedenmann, Stefanie Ehrhardt, Daniela Cerny, Dagmar Hildebrand, Sabrina Klein, Klaus Heeg, Katharina F. Kubatzky"]}} 
SRT |a WIEDENMANNERYTHROPOI3020 

Similar Items