Cover Image

A systematic review of pharmacological treatment options used to reduce ischemia reperfusion injury in rat liver transplantation

Background Although animal studies models are frequently used for the purpose of attenuating ischemia reperfusion injury (IRI) in liver transplantation (LT), many of pharmacological agents have not become part of clinical routine. Methods A search was performed using the PubMed database to identify...

Full description

Saved in:
Bibliographic Details
Main Authors: Yamanaka, Kenya (Author) , Houben, Philipp (Author) , Bruns, Helge (Author) , Schultze, Daniel (Author) , Schemmer, Peter (Author)
Format: Article (Journal)
Language:English
Published: 28 April 2015
In: PLOS ONE
Year: 2015, Volume: 10, Issue: 4
ISSN:1932-6203
DOI:10.1371/journal.pone.0122214
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1371/journal.pone.0122214
Verlag, kostenfrei, Volltext: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412498/
Get full text
Author Notes:Kenya Yamanaka, Philipp Houben, Helge Bruns, Daniel Schultze, Etsuro Hatano, Peter Schemmer

MARC

LEADER 00000caa a2200000 c 4500
001 1560642440
003 DE-627
005 20230428162053.0
007 cr uuu---uuuuu
008 170707s2015 xx |||||o 00| ||eng c
024 7 |a 10.1371/journal.pone.0122214  |2 doi 
035 |a (DE-627)1560642440 
035 |a (DE-576)490642446 
035 |a (DE-599)BSZ490642446 
035 |a (OCoLC)1340976660 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Yamanaka, Kenya  |e VerfasserIn  |0 (DE-588)1081182091  |0 (DE-627)845662260  |0 (DE-576)454014538  |4 aut 
245 1 2 |a A systematic review of pharmacological treatment options used to reduce ischemia reperfusion injury in rat liver transplantation  |c Kenya Yamanaka, Philipp Houben, Helge Bruns, Daniel Schultze, Etsuro Hatano, Peter Schemmer 
264 1 |c 28 April 2015 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 07.07.2015 
520 |a Background Although animal studies models are frequently used for the purpose of attenuating ischemia reperfusion injury (IRI) in liver transplantation (LT), many of pharmacological agents have not become part of clinical routine. Methods A search was performed using the PubMed database to identify agents, from which 58 articles containing 2700 rat LT procedures were selected. The identified pharmacological agents were categorized as follows: I - adenosine agonists, nitric oxide agonists, endothelin antagonists, and prostaglandins, II - Kupffer cell inactivator, III - complement inhibiter, IV - antioxidant, V - neutrophil inactivator, VI -anti-apoptosis agent, VII - heat shock protein and nuclear factor kappa B inducer, VIII - metabolic agent, IX - traditional Chinese medicine, and X - others. Meta-analysis using 7-day-survival rate was also performed with Mantel-Haenszel's Random effects model. Results The categorization revealed that the rate of donor-treated experiments in each group was highest for agents from Group II (70%) and VII (71%), whereas it was higher for agents from Group V (83%) in the recipient-treated experiments. Furthermore, 90% of the experiments with agents in Group II provided 7-day-survival benefits. The Risk Ratio (RR) of the meta-analysis was 2.43 [95% CI: 1.88-3.14] with moderate heterogeneity. However, the RR of each of the studies was too model-dependent to be used in the search for the most promising pharmacological agent. Conclusion With regard to hepatic IRI pathology, the categorization of agents of interest would be a first step in designing suitable multifactorial and pleiotropic approaches to develop pharmacological strategies. 
700 1 |a Houben, Philipp  |d 1982-  |e VerfasserIn  |0 (DE-588)1031409505  |0 (DE-627)73638023X  |0 (DE-576)378857029  |4 aut 
700 1 |a Bruns, Helge  |d 1976-  |e VerfasserIn  |0 (DE-588)133638561  |0 (DE-627)550286780  |0 (DE-576)299989119  |4 aut 
700 1 |a Schultze, Daniel  |d 1980-  |e VerfasserIn  |0 (DE-588)1054785260  |0 (DE-627)792111532  |0 (DE-576)410512958  |4 aut 
700 1 |a Schemmer, Peter  |d 1967-  |e VerfasserIn  |0 (DE-588)1022604244  |0 (DE-627)717006794  |0 (DE-576)365668230  |4 aut 
773 0 8 |i Enthalten in  |t PLOS ONE  |d San Francisco, California, US : PLOS, 2006  |g 10(2015,4) Artikel-Nummer e0122214, 16 Seiten  |h Online-Ressource  |w (DE-627)523574592  |w (DE-600)2267670-3  |w (DE-576)281331979  |x 1932-6203  |7 nnas  |a A systematic review of pharmacological treatment options used to reduce ischemia reperfusion injury in rat liver transplantation 
773 1 8 |g volume:10  |g year:2015  |g number:4  |a A systematic review of pharmacological treatment options used to reduce ischemia reperfusion injury in rat liver transplantation 
856 4 0 |u http://dx.doi.org/10.1371/journal.pone.0122214  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412498/  |x Verlag  |z kostenfrei  |3 Volltext 
951 |a AR 
992 |a 20170707 
993 |a Article 
994 |a 2015 
998 |g 1022604244  |a Schemmer, Peter  |m 1022604244:Schemmer, Peter  |d 910000  |d 910200  |e 910000PS1022604244  |e 910200PS1022604244  |k 0/910000/  |k 1/910000/910200/  |p 6  |y j 
998 |g 1054785260  |a Schultze, Daniel  |m 1054785260:Schultze, Daniel  |d 910000  |d 910200  |e 910000PS1054785260  |e 910200PS1054785260  |k 0/910000/  |k 1/910000/910200/  |p 4 
998 |g 133638561  |a Bruns, Helge  |m 133638561:Bruns, Helge  |d 910000  |d 910200  |e 910000PB133638561  |e 910200PB133638561  |k 0/910000/  |k 1/910000/910200/  |p 3 
998 |g 1031409505  |a Houben, Philipp  |m 1031409505:Houben, Philipp  |d 910000  |d 910200  |e 910000PH1031409505  |e 910200PH1031409505  |k 0/910000/  |k 1/910000/910200/  |p 2 
998 |g 1081182091  |a Yamanaka, Kenya  |m 1081182091:Yamanaka, Kenya  |d 910000  |d 910200  |e 910000PY1081182091  |e 910200PY1081182091  |k 0/910000/  |k 1/910000/910200/  |p 1  |x j 
999 |a KXP-PPN1560642440  |e 2973441978 
BIB |a Y 
SER |a journal 
JSO |a {"id":{"eki":["1560642440"],"doi":["10.1371/journal.pone.0122214"]},"title":[{"title":"A systematic review of pharmacological treatment options used to reduce ischemia reperfusion injury in rat liver transplantation","title_sort":"systematic review of pharmacological treatment options used to reduce ischemia reperfusion injury in rat liver transplantation"}],"origin":[{"dateIssuedKey":"2015","dateIssuedDisp":"28 April 2015"}],"name":{"displayForm":["Kenya Yamanaka, Philipp Houben, Helge Bruns, Daniel Schultze, Etsuro Hatano, Peter Schemmer"]},"person":[{"given":"Kenya","family":"Yamanaka","role":"aut","roleDisplay":"VerfasserIn","display":"Yamanaka, Kenya"},{"given":"Philipp","family":"Houben","role":"aut","display":"Houben, Philipp","roleDisplay":"VerfasserIn"},{"given":"Helge","family":"Bruns","role":"aut","roleDisplay":"VerfasserIn","display":"Bruns, Helge"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Schultze, Daniel","given":"Daniel","family":"Schultze"},{"role":"aut","display":"Schemmer, Peter","roleDisplay":"VerfasserIn","given":"Peter","family":"Schemmer"}],"recId":"1560642440","language":["eng"],"relHost":[{"id":{"zdb":["2267670-3"],"eki":["523574592"],"issn":["1932-6203"]},"origin":[{"publisherPlace":"San Francisco, California, US ; Lawrence, Kan.","dateIssuedKey":"2006","publisher":"PLOS ; PLoS","dateIssuedDisp":"2006-"}],"name":{"displayForm":["Public Library of Science"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"PLOS ONE","title_sort":"PLOS ONE"}],"part":{"year":"2015","issue":"4","text":"10(2015,4) Artikel-Nummer e0122214, 16 Seiten","volume":"10"},"pubHistory":["1.2006 -"],"corporate":[{"display":"Public Library of Science","roleDisplay":"Herausgebendes Organ","role":"isb"}],"language":["eng"],"recId":"523574592","disp":"A systematic review of pharmacological treatment options used to reduce ischemia reperfusion injury in rat liver transplantationPLOS ONE","note":["Schreibweise des Titels bis 2012: PLoS ONE","Gesehen am 20.03.19"],"type":{"media":"Online-Ressource","bibl":"periodical"}}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 07.07.2015"]} 
SRT |a YAMANAKAKESYSTEMATIC2820 

Similar Items