Cell division patterns in acute myeloid leukemia stem-like cells determine clinical course: a model to predict patient survival
Acute myeloid leukemia (AML) is a heterogeneous disease in which a variety of distinct genetic alterations might occur. Recent attempts to identify the leukemia stem-like cells (LSC) have also indicated heterogeneity of these cells. On the basis of mathematical modeling and computer simulations, we...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
January 22, 2015
|
| In: |
Cancer research
Year: 2015, Jahrgang: 75, Heft: 6, Pages: 940-949 |
| ISSN: | 1538-7445 |
| DOI: | 10.1158/0008-5472.CAN-14-2508 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1158/0008-5472.CAN-14-2508 Verlag, Volltext: http://cancerres.aacrjournals.org/content/75/6/940 
|
| Verfasserangaben: | Thomas Stiehl, Natalia Baran, Anthony D. Ho, Anna Marciniak-Czochra |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1561436577 | ||
| 003 | DE-627 | ||
| 005 | 20230427122019.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 170801s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1158/0008-5472.CAN-14-2508 |2 doi | |
| 035 | |a (DE-627)1561436577 | ||
| 035 | |a (DE-576)491436572 | ||
| 035 | |a (DE-599)BSZ491436572 | ||
| 035 | |a (OCoLC)1340977882 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Stiehl, Thomas |e VerfasserIn |0 (DE-588)1053844999 |0 (DE-627)790793342 |0 (DE-576)409783927 |4 aut | |
| 245 | 1 | 0 | |a Cell division patterns in acute myeloid leukemia stem-like cells determine clinical course |b a model to predict patient survival |c Thomas Stiehl, Natalia Baran, Anthony D. Ho, Anna Marciniak-Czochra |
| 264 | 1 | |c January 22, 2015 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 01.08.2017 | ||
| 520 | |a Acute myeloid leukemia (AML) is a heterogeneous disease in which a variety of distinct genetic alterations might occur. Recent attempts to identify the leukemia stem-like cells (LSC) have also indicated heterogeneity of these cells. On the basis of mathematical modeling and computer simulations, we have provided evidence that proliferation and self-renewal rates of the LSC population have greater impact on the course of disease than proliferation and self-renewal rates of leukemia blast populations, that is, leukemia progenitor cells. The modeling approach has enabled us to estimate the LSC properties of 31 individuals with relapsed AML and to link them to patient survival. On the basis of the estimated LSC properties, the patients can be divided into two prognostic groups that differ significantly with respect to overall survival after first relapse. The results suggest that high LSC self-renewal and proliferation rates are indicators of poor prognosis. Nevertheless, high LSC self-renewal rate may partially compensate for slow LSC proliferation and vice versa. Thus, model-based interpretation of clinical data allows estimation of prognostic factors that cannot be measured directly. This may have clinical implications for designing treatment strategies. Cancer Res; 75(6); 940-9. ©2015 AACR. | ||
| 700 | 1 | |a Baran, Natalia |e VerfasserIn |0 (DE-588)105405200X |0 (DE-627)791013499 |0 (DE-576)409974609 |4 aut | |
| 700 | 1 | |a Ho, Anthony Dick |d 1948- |e VerfasserIn |0 (DE-588)108692477 |0 (DE-627)504904205 |0 (DE-576)19010466X |4 aut | |
| 700 | 1 | |a Marciniak-Czochra, Anna |d 1974- |e VerfasserIn |0 (DE-588)1044379626 |0 (DE-627)771928432 |0 (DE-576)397031505 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancer research |d Philadelphia, Pa. : AACR, 1941 |g 75(2015), 6, Seite 940-949 |h Online-Ressource |w (DE-627)325489955 |w (DE-600)2036785-5 |w (DE-576)094502226 |x 1538-7445 |7 nnas |a Cell division patterns in acute myeloid leukemia stem-like cells determine clinical course a model to predict patient survival |
| 773 | 1 | 8 | |g volume:75 |g year:2015 |g number:6 |g pages:940-949 |g extent:10 |a Cell division patterns in acute myeloid leukemia stem-like cells determine clinical course a model to predict patient survival |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1158/0008-5472.CAN-14-2508 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://cancerres.aacrjournals.org/content/75/6/940 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20170801 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 1044379626 |a Marciniak-Czochra, Anna |m 1044379626:Marciniak-Czochra, Anna |d 110000 |d 110200 |d 110000 |d 110400 |e 110000PM1044379626 |e 110200PM1044379626 |e 110000PM1044379626 |e 110400PM1044379626 |k 0/110000/ |k 1/110000/110200/ |k 0/110000/ |k 1/110000/110400/ | ||
| 998 | |g 108692477 |a Ho, Anthony Dick |m 108692477:Ho, Anthony Dick |d 910000 |d 910100 |e 910000PH108692477 |e 910100PH108692477 |k 0/910000/ |k 1/910000/910100/ | ||
| 998 | |g 105405200X |a Baran, Natalia |m 105405200X:Baran, Natalia |d 910000 |d 910100 |e 910000PB105405200X |e 910100PB105405200X |k 0/910000/ |k 1/910000/910100/ |p 2 | ||
| 998 | |g 1053844999 |a Stiehl, Thomas |m 1053844999:Stiehl, Thomas |d 700000 |d 708000 |e 700000PS1053844999 |e 708000PS1053844999 |k 0/700000/ |k 1/700000/708000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1561436577 |e 2975776586 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 01.08.2017"],"recId":"1561436577","language":["eng"],"title":[{"title_sort":"Cell division patterns in acute myeloid leukemia stem-like cells determine clinical course","title":"Cell division patterns in acute myeloid leukemia stem-like cells determine clinical course","subtitle":"a model to predict patient survival"}],"person":[{"family":"Stiehl","given":"Thomas","display":"Stiehl, Thomas","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Baran","given":"Natalia","display":"Baran, Natalia","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Ho, Anthony Dick","given":"Anthony Dick","family":"Ho"},{"display":"Marciniak-Czochra, Anna","roleDisplay":"VerfasserIn","role":"aut","family":"Marciniak-Czochra","given":"Anna"}],"physDesc":[{"extent":"10 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["2036785-5"],"eki":["325489955"],"issn":["1538-7445"]},"origin":[{"dateIssuedDisp":"1941-","publisher":"AACR","dateIssuedKey":"1941","publisherPlace":"Philadelphia, Pa."}],"name":{"displayForm":["American Association for Cancer Research"]},"part":{"extent":"10","text":"75(2015), 6, Seite 940-949","volume":"75","pages":"940-949","issue":"6","year":"2015"},"pubHistory":["Volume 1, issue 1 (1 January 1941)-"],"corporate":[{"roleDisplay":"Herausgebendes Organ","display":"American Association for Cancer Research","role":"isb"}],"language":["eng"],"recId":"325489955","note":["Gesehen am 31.03.25","Fortsetzung der Druck-Ausgabe"],"disp":"Cell division patterns in acute myeloid leukemia stem-like cells determine clinical course a model to predict patient survivalCancer research","type":{"bibl":"periodical","media":"Online-Ressource"},"title":[{"title_sort":"Cancer research","title":"Cancer research"}]}],"origin":[{"dateIssuedKey":"2015","dateIssuedDisp":"January 22, 2015"}],"id":{"doi":["10.1158/0008-5472.CAN-14-2508"],"eki":["1561436577"]},"name":{"displayForm":["Thomas Stiehl, Natalia Baran, Anthony D. Ho, Anna Marciniak-Czochra"]}} | ||
| SRT | |a STIEHLTHOMCELLDIVISI2220 | ||