Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis
During Xenopus development, Wnt signaling is thought to function first after midblastula transition to regulate axial patterning via β-catenin-mediated transcription. Here, we report that Wnt/glycogen synthase kinase 3 (GSK3) signaling functions posttranscriptionally already in mature oocytes via Wn...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 31, 2015
|
| In: |
Proceedings of the National Academy of Sciences of the United States of America
Year: 2015, Jahrgang: 112, Heft: 18, Pages: 5732-5737 |
| ISSN: | 1091-6490 |
| DOI: | 10.1073/pnas.1423533112 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1073/pnas.1423533112 Verlag, kostenfrei, Volltext: http://www.pnas.org/content/112/18/5732 
|
| Verfasserangaben: | Ya-Lin Huang, Zeinab Anvarian, Gabriele Döderlein, Sergio P. Acebron, and Christof Niehrs |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 156169696X | ||
| 003 | DE-627 | ||
| 005 | 20220813205002.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 170803s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1073/pnas.1423533112 |2 doi | |
| 035 | |a (DE-627)156169696X | ||
| 035 | |a (DE-576)491696965 | ||
| 035 | |a (DE-599)BSZ491696965 | ||
| 035 | |a (OCoLC)1340978160 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Huang, Ya-Lin |e VerfasserIn |0 (DE-588)143195026 |0 (DE-627)704417200 |0 (DE-576)33556948X |4 aut | |
| 245 | 1 | 0 | |a Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis |c Ya-Lin Huang, Zeinab Anvarian, Gabriele Döderlein, Sergio P. Acebron, and Christof Niehrs |
| 264 | 1 | |c March 31, 2015 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 03.08.2017 | ||
| 520 | |a During Xenopus development, Wnt signaling is thought to function first after midblastula transition to regulate axial patterning via β-catenin-mediated transcription. Here, we report that Wnt/glycogen synthase kinase 3 (GSK3) signaling functions posttranscriptionally already in mature oocytes via Wnt/stabilization of proteins (STOP) signaling. Wnt signaling is induced in oocytes after their entry into meiotic metaphase II and declines again upon exit into interphase. Wnt signaling inhibits Gsk3 and thereby protects proteins from polyubiquitination and degradation in mature oocytes. In a protein array screen, we identify a cluster of mitotic effector proteins that are polyubiquitinated in a Gsk3-dependent manner in Xenopus. Consequently inhibition of maternal Wnt/STOP signaling, but not β-catenin signaling, leads to early cleavage arrest after fertilization. The results support a novel role for Wnt signaling in cell cycle progression independent of β-catenin. | ||
| 650 | 4 | |a GSK3 | |
| 650 | 4 | |a mitosis | |
| 650 | 4 | |a proteolysis | |
| 650 | 4 | |a Wnt/STOP | |
| 650 | 4 | |a Xenopus | |
| 700 | 1 | |a Anvarian, Zeinab |e VerfasserIn |0 (DE-588)1137651547 |0 (DE-627)895022486 |0 (DE-576)491696779 |4 aut | |
| 700 | 1 | |a Döderlein, Gabriele |e VerfasserIn |0 (DE-588)1137651253 |0 (DE-627)895021501 |0 (DE-576)491695837 |4 aut | |
| 700 | 1 | |a Acebron, Sergio P. |e VerfasserIn |0 (DE-588)1137651474 |0 (DE-627)895022087 |0 (DE-576)491696272 |4 aut | |
| 700 | 1 | |a Niehrs, Christof |d 1962- |e VerfasserIn |0 (DE-588)112676324 |0 (DE-627)729343014 |0 (DE-576)373331754 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a National Academy of Sciences (Washington, DC) |t Proceedings of the National Academy of Sciences of the United States of America |d Washington, DC : National Acad. of Sciences, 1915 |g 112(2015), 18, Seite 5732-5737 |h Online-Ressource |w (DE-627)254235379 |w (DE-600)1461794-8 |w (DE-576)073260509 |x 1091-6490 |7 nnas |
| 773 | 1 | 8 | |g volume:112 |g year:2015 |g number:18 |g pages:5732-5737 |g extent:6 |a Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1073/pnas.1423533112 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://www.pnas.org/content/112/18/5732 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20170803 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 112676324 |a Niehrs, Christof |m 112676324:Niehrs, Christof |d 140000 |e 140000PN112676324 |k 0/140000/ |p 5 |y j | ||
| 998 | |g 1137651474 |a Acebron, Sergio P. |m 1137651474:Acebron, Sergio P. |d 140000 |e 140000PA1137651474 |k 0/140000/ |p 4 | ||
| 998 | |g 1137651253 |a Döderlein, Gabriele |m 1137651253:Döderlein, Gabriele |p 3 | ||
| 998 | |g 1137651547 |a Anvarian, Zeinab |m 1137651547:Anvarian, Zeinab |p 2 | ||
| 998 | |g 143195026 |a Huang, Ya-Lin |m 143195026:Huang, Ya-Lin |p 1 |x j | ||
| 999 | |a KXP-PPN156169696X |e 2976248834 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"name":{"displayForm":["Ya-Lin Huang, Zeinab Anvarian, Gabriele Döderlein, Sergio P. Acebron, and Christof Niehrs"]},"title":[{"title_sort":"Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis","title":"Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis"}],"relHost":[{"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"National Academy of Sciences (Washington, DC)Proceedings of the National Academy of Sciences of the United States of America","note":["Gesehen am 09.03.2022"],"physDesc":[{"extent":"Online-Ressource"}],"recId":"254235379","corporate":[{"display":"National Academy of Sciences","roleDisplay":"VerfasserIn","role":"aut"}],"language":["eng"],"pubHistory":["1.1915 -"],"titleAlt":[{"title":"PNAS online"},{"title":"PNAS"}],"title":[{"title_sort":"Proceedings of the National Academy of Sciences of the United States of America","title":"Proceedings of the National Academy of Sciences of the United States of America"}],"id":{"zdb":["1461794-8"],"eki":["254235379"],"issn":["1091-6490"]},"origin":[{"dateIssuedKey":"1915","publisherPlace":"Washington, DC","publisher":"National Acad. of Sciences","dateIssuedDisp":"1915-"}],"part":{"year":"2015","extent":"6","text":"112(2015), 18, Seite 5732-5737","issue":"18","volume":"112","pages":"5732-5737"}}],"origin":[{"dateIssuedKey":"2015","dateIssuedDisp":"March 31, 2015"}],"id":{"eki":["156169696X"],"doi":["10.1073/pnas.1423533112"]},"person":[{"given":"Ya-Lin","family":"Huang","display":"Huang, Ya-Lin","role":"aut","roleDisplay":"VerfasserIn"},{"given":"Zeinab","family":"Anvarian","display":"Anvarian, Zeinab","roleDisplay":"VerfasserIn","role":"aut"},{"roleDisplay":"VerfasserIn","role":"aut","display":"Döderlein, Gabriele","family":"Döderlein","given":"Gabriele"},{"roleDisplay":"VerfasserIn","role":"aut","display":"Acebron, Sergio P.","family":"Acebron","given":"Sergio P."},{"roleDisplay":"VerfasserIn","role":"aut","display":"Niehrs, Christof","family":"Niehrs","given":"Christof"}],"note":["Gesehen am 03.08.2017"],"language":["eng"],"recId":"156169696X","physDesc":[{"extent":"6 S."}]} | ||
| SRT | |a HUANGYALINMATERNALWN3120 | ||