Mismatch repair-deficient crypt foci in Lynch syndrome: molecular alterations and association with clinical parameters

Lynch syndrome is caused by germline mutations of DNA mismatch repair (MMR) genes, most frequently MLH1 and MSH2. Recently, MMR-deficient crypt foci (MMR-DCF) have been identified as a novel lesion which occurs at high frequency in the intestinal mucosa from Lynch syndrome mutation carriers, but ver...

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Bibliographic Details

Main Authors:	Staffa, Laura (Author) , Echterdiek, Fabian Friedrich (Author) , Nelius, Nina (Author) , Benner, Axel (Author) , Werft, Wiebke (Author) , Lahrmann, Bernd (Author) , Grabe, Niels (Author) , Schneider, Martin (Author) , Tariverdian, Mirjam (Author) , Knebel Doeberitz, Magnus von (Author) , Kloor, Matthias (Author)
Format:	Article (Journal)
Language:	English
Published:	March 27, 2015
In:	PLOS ONE Year: 2015, Volume: 10, Issue: 3, Pages: 1-15
ISSN:	1932-6203
DOI:	10.1371/journal.pone.0121980
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1371/journal.pone.0121980 Verlag, kostenfrei, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121980 Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1371/journal.pone.0121980 Verlag, kostenfrei, Volltext: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376900/
Author Notes:	Laura Staffa, Fabian Echterdiek, Nina Nelius, Axel Benner, Wiebke Werft, Bernd Lahrmann, Niels Grabe, Martin Schneider, Mirjam Tariverdian, Magnus von Knebel Doeberitz, Hendrik Bläker, Matthias Kloor