Dual gold(I)-catalyzed cyclization of dialkynyl pyridinium salts
Novel dialkynyl pyridines were synthesized and protected as alkyl salts for dual gold(I)-catalyzed cycloisomerization. Different alkyl groups and counter ions were screened for the salts, with benzyl and hexafluorophosphate providing the best results. The cyclization led to NMR yields of >95 % be...
Gespeichert in:
| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
18 May 2017
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| In: |
ChemCatChem
Year: 2017, Jahrgang: 9, Heft: 11, Pages: 1915-1920 |
| ISSN: | 1867-3899 |
| DOI: | 10.1002/cctc.201700018 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1002/cctc.201700018 Verlag, Volltext: http://onlinelibrary.wiley.com/doi/10.1002/cctc.201700018/epdf Verlag, Volltext: http://onlinelibrary.wiley.com/doi/10.1002/cctc.201700018/abstract |
| Verfasserangaben: | Svetlana Tšupova, Alban Cadu, Fabian Stuck, Frank Rominger, Matthias Rudolph, Joseph S.M. Samec, A. Stephen K. Hashmi |
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| 520 | |a Novel dialkynyl pyridines were synthesized and protected as alkyl salts for dual gold(I)-catalyzed cycloisomerization. Different alkyl groups and counter ions were screened for the salts, with benzyl and hexafluorophosphate providing the best results. The cyclization led to NMR yields of >95 % being obtained for a number of substrates. Step-wise hydrogenation of products could be performed in one-pot by Pd/C, with selective reduction of the double bonds, followed by deprotection of the benzyl group. | ||
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