Total synthesis of (±)-dihydroisosubamol
We herein report the first total synthesis of the dibenzocycloheptanoide (±)-dihydroisosubamol. The key step includes a recently developed gold-catalysed hydroarylation reaction for the construction of the dibenzocycloheptene motif. Additional steps are a Suzuki-Miyaura cross coupling, a palladium-c...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2017
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| In: |
Advanced synthesis & catalysis
Year: 2016, Jahrgang: 359, Heft: 5, Pages: 866-874 |
| ISSN: | 1615-4169 |
| DOI: | 10.1002/adsc.201600663 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1002/adsc.201600663 Verlag, Volltext: http://onlinelibrary.wiley.com/doi/10.1002/adsc.201600663/abstract 
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| Verfasserangaben: | Daniel Pflästerer, Matthias Rudolph, Brian F. Yates, Alireza Ariafard, and A. Stephen K. Hashmi |
| Zusammenfassung: | We herein report the first total synthesis of the dibenzocycloheptanoide (±)-dihydroisosubamol. The key step includes a recently developed gold-catalysed hydroarylation reaction for the construction of the dibenzocycloheptene motif. Additional steps are a Suzuki-Miyaura cross coupling, a palladium-catalysed hydroxylation and an allylic oxidation. To access the saturated seven-membered ring system an iridium-catalysed hydrogenation proved to be successful. |
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| Beschreibung: | Online published: 23 December 2016 Gesehen am 23.08.2017 |
| Beschreibung: | Online Resource |
| ISSN: | 1615-4169 |
| DOI: | 10.1002/adsc.201600663 |