A potential role for mechanical forces in the detachment of podocytes and the progression of CKD
Loss of podocytes underlies progression of CKD. Detachment of podocytes from the glomerular basement membrane (GBM) rather than apoptosis or necrosis seems to be the major mechanism of podocyte loss. Such detachment of viable podocytes may be caused by increased mechanical distending and shear force...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 24, 2014
|
| In: |
Journal of the American Society of Nephrology
Year: 2014, Jahrgang: 26, Heft: 2, Pages: 258-269 |
| ISSN: | 1533-3450 |
| DOI: | 10.1681/ASN.2014030278 |
| Online-Zugang: | Verlag, teilw. kostenfrei, Volltext: http://dx.doi.org/10.1681/ASN.2014030278 Verlag, teilw. kostenfrei, Volltext: http://jasn.asnjournals.org.ezproxy.medma.uni-heidelberg.de/content/26/2/258 
|
| Verfasserangaben: | Wilhelm Kriz and Kevin V. Lemley |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1562728903 | ||
| 003 | DE-627 | ||
| 005 | 20220813215230.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 170825r20152014xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1681/ASN.2014030278 |2 doi | |
| 035 | |a (DE-627)1562728903 | ||
| 035 | |a (DE-576)492728909 | ||
| 035 | |a (DE-599)BSZ492728909 | ||
| 035 | |a (OCoLC)1340978880 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Kriz, Wilhelm |d 1936- |e VerfasserIn |0 (DE-588)172197570 |0 (DE-627)69711130X |0 (DE-576)133067750 |4 aut | |
| 245 | 1 | 2 | |a A potential role for mechanical forces in the detachment of podocytes and the progression of CKD |c Wilhelm Kriz and Kevin V. Lemley |
| 264 | 1 | |c July 24, 2014 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.08.2017 | ||
| 520 | |a Loss of podocytes underlies progression of CKD. Detachment of podocytes from the glomerular basement membrane (GBM) rather than apoptosis or necrosis seems to be the major mechanism of podocyte loss. Such detachment of viable podocytes may be caused by increased mechanical distending and shear forces and/or impaired adhesion to the GBM. This review considers the mechanical challenges that may lead to podocyte loss by detachment from the GBM under physiologic and pathophysiologic conditions, including glomerular hypertension, hyperfiltration, hypertrophy, and outflow of filtrate from subpodocyte spaces. Furthermore, we detail the cellular mechanisms by which podocytes respond to these challenges, discuss the protective effects of angiotensin blockade, and note the questions that must be addressed to better understand the relationship between podocyte detachment and progression of CKD. | ||
| 534 | |c 2014 | ||
| 650 | 4 | |a foot process effacement | |
| 650 | 4 | |a mechanical forces | |
| 650 | 4 | |a podocyte detachment | |
| 650 | 4 | |a progression of chronic renal failure | |
| 700 | 1 | |a Lemley, Kevin V. |e VerfasserIn |0 (DE-588)1138840815 |0 (DE-627)896470997 |0 (DE-576)49272718X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a American Society of Nephrology |t Journal of the American Society of Nephrology |d Washington, DC : American Society of Nephrology, 1990 |g 26(2015), 2, Seite 258-269 |h Online-Ressource |w (DE-627)324616481 |w (DE-600)2029124-3 |w (DE-576)094113769 |x 1533-3450 |7 nnas |
| 773 | 1 | 8 | |g volume:26 |g year:2015 |g number:2 |g pages:258-269 |g extent:12 |a A potential role for mechanical forces in the detachment of podocytes and the progression of CKD |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1681/ASN.2014030278 |x Verlag |x Resolving-System |z teilw. kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://jasn.asnjournals.org.ezproxy.medma.uni-heidelberg.de/content/26/2/258 |x Verlag |z teilw. kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20170825 | ||
| 993 | |a Article | ||
| 994 | |a 2015 | ||
| 998 | |g 172197570 |a Kriz, Wilhelm |m 172197570:Kriz, Wilhelm |d 60000 |d 999810 |d 50000 |d 53100 |e 60000PK172197570 |e 999810PK172197570 |e 50000PK172197570 |e 53100PK172197570 |k 0/60000/ |k 1/60000/999810/ |k 0/50000/ |k 1/50000/53100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1562728903 |e 2978454377 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"recId":"1562728903","type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 25.08.2017"],"title":[{"title_sort":"potential role for mechanical forces in the detachment of podocytes and the progression of CKD","title":"A potential role for mechanical forces in the detachment of podocytes and the progression of CKD"}],"person":[{"given":"Wilhelm","family":"Kriz","role":"aut","display":"Kriz, Wilhelm","roleDisplay":"VerfasserIn"},{"family":"Lemley","given":"Kevin V.","display":"Lemley, Kevin V.","roleDisplay":"VerfasserIn","role":"aut"}],"relHost":[{"origin":[{"dateIssuedDisp":"1990-","publisher":"American Society of Nephrology ; Ovid","dateIssuedKey":"1990","publisherPlace":"Washington, DC ; [Erscheinungsort nicht ermittelbar]"}],"id":{"zdb":["2029124-3"],"eki":["324616481"],"issn":["1533-3450"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Journal of the American Society of Nephrology","subtitle":"JASN","title_sort":"Journal of the American Society of Nephrology"}],"pubHistory":["1.1990 -"],"part":{"year":"2015","pages":"258-269","issue":"2","volume":"26","text":"26(2015), 2, Seite 258-269","extent":"12"},"titleAlt":[{"title":"JASN"}],"disp":"American Society of NephrologyJournal of the American Society of Nephrology","note":["Gesehen am 19.08.24"],"type":{"media":"Online-Ressource","bibl":"periodical"},"corporate":[{"display":"American Society of Nephrology","roleDisplay":"VerfasserIn","role":"aut"}],"language":["eng"],"recId":"324616481"}],"physDesc":[{"extent":"12 S."}],"id":{"doi":["10.1681/ASN.2014030278"],"eki":["1562728903"]},"origin":[{"dateIssuedDisp":"July 24, 2014","dateIssuedKey":"2015"}],"name":{"displayForm":["Wilhelm Kriz and Kevin V. Lemley"]}} | ||
| SRT | |a KRIZWILHELPOTENTIALR2420 | ||