Endobronchial valve therapy in patients with homogeneous emphysema: results from the IMPACT study
Rationale: Endobronchial valves (EBVs) have been successfully used in patients with severe heterogeneous emphysema to improve lung physiology. Limited available data suggest that EBVs are also effective in homogeneous emphysema.Objectives: To evaluate the efficacy and safety of EBVs in patients with...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
31 August 2016
|
| In: |
American journal of respiratory and critical care medicine
Year: 2016, Jahrgang: 194, Heft: 9, Pages: 1073-1082 |
| ISSN: | 1535-4970 |
| DOI: | 10.1164/rccm.201607-1383OC |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1164/rccm.201607-1383OC Verlag, kostenfrei, Volltext: http://www.atsjournals.org/doi/abs/10.1164/rccm.201607-1383OC 
|
| Verfasserangaben: | Arschang Valipour, Dirk-Jan Slebos, Felix Herth, Kaid Darwiche, Manfred Wagner, Joachim H. Ficker, Christoph Petermann, Ralf-Harto Hubner, Franz Stanzel, Ralf Eberhardt |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1562795074 | ||
| 003 | DE-627 | ||
| 005 | 20230427122042.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 170828s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1164/rccm.201607-1383OC |2 doi | |
| 035 | |a (DE-627)1562795074 | ||
| 035 | |a (DE-576)49279507X | ||
| 035 | |a (DE-599)BSZ49279507X | ||
| 035 | |a (OCoLC)1340978849 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Valipour, Arschang |e VerfasserIn |0 (DE-588)1138951897 |0 (DE-627)896569888 |0 (DE-576)492793344 |4 aut | |
| 245 | 1 | 0 | |a Endobronchial valve therapy in patients with homogeneous emphysema |b results from the IMPACT study |c Arschang Valipour, Dirk-Jan Slebos, Felix Herth, Kaid Darwiche, Manfred Wagner, Joachim H. Ficker, Christoph Petermann, Ralf-Harto Hubner, Franz Stanzel, Ralf Eberhardt |
| 264 | 1 | |c 31 August 2016 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 28.08.2017 | ||
| 520 | |a Rationale: Endobronchial valves (EBVs) have been successfully used in patients with severe heterogeneous emphysema to improve lung physiology. Limited available data suggest that EBVs are also effective in homogeneous emphysema.Objectives: To evaluate the efficacy and safety of EBVs in patients with homogeneous emphysema with absence of collateral ventilation assessed with the Chartis system.Methods: Prospective, multicenter, 1:1 randomized controlled trial of EBV plus standard of care (SoC) or SoC alone. Primary outcome was the percentage change in FEV1 (liters) at 3 months relative to baseline in the EBV group versus the SoC group. Secondary outcomes included changes in FEV1, St. George’s Respiratory Questionnaire (SGRQ), 6-minute-walk distance (6MWD), and target lobe volume reduction.Measurements and Main Results: Ninety-three subjects (age, 63.7 ± 6.1 yr [mean ± SD]; FEV1, % predicted, 29.3 ± 6.5; residual volume, % predicted, 275.4 ± 59.4) were allocated to either the EBV group (n = 43) or the SoC group (n = 50). In the intention-to-treat population, at 3 months postprocedure, improvement in FEV1 from baseline was 13.7 ± 28.2% in the EBV group and −3.2 ± 13.0% in the SoC group (mean between-group difference, 17.0%; P = 0.0002). Other variables demonstrated statistically and clinically significant changes from baseline to 3 months (EBV vs. SoC, respectively: SGRQ, −8.63 ± 11.25 vs. 1.01 ± 9.36; and 6MWD, 22.63 ± 66.63 m vs. −17.34 ± 52.8 m). Target lobe volume reduction at 3 months was −1,195 ± 683 ml (P < 0.0001). Of the EBV subjects, 97.2% achieved volume reduction in the target lobe (P < 0.0001). Procedure-related pneumothoraces occurred in 11 subjects (25.6%). Five subjects required removal/replacement of one or more valves. One subject experienced two valve migration events requiring removal/replacement of valves.Conclusions: EBV in patients with homogeneous emphysema without collateral ventilation results in clinically meaningful benefits of improved lung function, exercise tolerance, and quality of life. | ||
| 700 | 1 | |a Herth, Felix |e VerfasserIn |0 (DE-588)1016095236 |0 (DE-627)705477568 |0 (DE-576)351509925 |4 aut | |
| 700 | 1 | |a Eberhardt, Ralf |e VerfasserIn |0 (DE-588)1055080406 |0 (DE-627)792649133 |0 (DE-576)176462120 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t American journal of respiratory and critical care medicine |d New York, NY : American Thoracic Society, 1959 |g 194(2016), 9, Seite 1073-1082 |h Online-Ressource |w (DE-627)26688492X |w (DE-600)1468352-0 |w (DE-576)075961563 |x 1535-4970 |7 nnas |a Endobronchial valve therapy in patients with homogeneous emphysema results from the IMPACT study |
| 773 | 1 | 8 | |g volume:194 |g year:2016 |g number:9 |g pages:1073-1082 |g extent:10 |a Endobronchial valve therapy in patients with homogeneous emphysema results from the IMPACT study |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1164/rccm.201607-1383OC |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://www.atsjournals.org/doi/abs/10.1164/rccm.201607-1383OC |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20170828 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 1055080406 |a Eberhardt, Ralf |m 1055080406:Eberhardt, Ralf |d 910000 |d 950000 |d 950900 |d 50000 |e 910000PE1055080406 |e 950000PE1055080406 |e 950900PE1055080406 |e 50000PE1055080406 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |k 0/50000/ |p 10 |y j | ||
| 998 | |g 1016095236 |a Herth, Felix |m 1016095236:Herth, Felix |d 910000 |d 950000 |d 950900 |d 50000 |e 910000PH1016095236 |e 950000PH1016095236 |e 950900PH1016095236 |e 50000PH1016095236 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |k 0/50000/ |p 3 | ||
| 999 | |a KXP-PPN1562795074 |e 2978655992 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":"31 August 2016","dateIssuedKey":"2016"}],"person":[{"display":"Valipour, Arschang","role":"aut","given":"Arschang","family":"Valipour"},{"display":"Herth, Felix","family":"Herth","role":"aut","given":"Felix"},{"role":"aut","given":"Ralf","family":"Eberhardt","display":"Eberhardt, Ralf"}],"relHost":[{"pubHistory":["80.1959 -"],"titleAlt":[{"title":"AJRCCM online"},{"title":"AJRCCM"},{"title":"American review of respiratory diseases"}],"corporate":[{"display":"American Thoracic Society","role":"isb"}],"part":{"year":"2016","volume":"194","pages":"1073-1082","text":"194(2016), 9, Seite 1073-1082","extent":"10","issue":"9"},"id":{"zdb":["1468352-0"],"issn":["1535-4970"],"eki":["26688492X"]},"origin":[{"publisherPlace":"New York, NY ; New York, NY","dateIssuedKey":"1959","dateIssuedDisp":"1959-","publisher":"American Thoracic Society ; American Lung Association"}],"title":[{"subtitle":"AJRCCM ; an official journal of the American Thoracic Society, Medical Section of the Lung Association","title":"American journal of respiratory and critical care medicine","title_sort":"American journal of respiratory and critical care medicine"}],"note":["Gesehen am 17.01.2022"],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"26688492X","physDesc":[{"extent":"Online-Ressource"}],"disp":"Endobronchial valve therapy in patients with homogeneous emphysema results from the IMPACT studyAmerican journal of respiratory and critical care medicine"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"note":["Gesehen am 28.08.2017"],"title":[{"subtitle":"results from the IMPACT study","title_sort":"Endobronchial valve therapy in patients with homogeneous emphysema","title":"Endobronchial valve therapy in patients with homogeneous emphysema"}],"physDesc":[{"extent":"10 S."}],"recId":"1562795074","name":{"displayForm":["Arschang Valipour, Dirk-Jan Slebos, Felix Herth, Kaid Darwiche, Manfred Wagner, Joachim H. Ficker, Christoph Petermann, Ralf-Harto Hubner, Franz Stanzel, Ralf Eberhardt"]},"id":{"eki":["1562795074"],"doi":["10.1164/rccm.201607-1383OC"]}} | ||
| SRT | |a VALIPOURARENDOBRONCH3120 | ||