Effects of a chronic myositis on structural and functional features of spinal astrocytes in the rat
The study aimed at the question if astrocytes react with morphological or functional changes when a skeletal muscle is pathologically altered. In rats, a myositis was induced in the gastrocnemius-soleus muscle. After 12 days, the immunoreactivity (IR) for glial fibrillary acidic protein (GFAP), morp...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
9. April 2004
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| In: |
Neuroscience letters
Year: 2004, Volume: 361, Issue: 1, Pages: 196-199 |
| ISSN: | 1872-7972 |
| DOI: | 10.1016/j.neulet.2003.12.003 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.neulet.2003.12.003 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0304394003013831 
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| Author Notes: | S. Tenschert, A. Reinert, U. Hoheisel, S. Mense |
| Summary: | The study aimed at the question if astrocytes react with morphological or functional changes when a skeletal muscle is pathologically altered. In rats, a myositis was induced in the gastrocnemius-soleus muscle. After 12 days, the immunoreactivity (IR) for glial fibrillary acidic protein (GFAP), morphometric parameters, and fibroblast growth factor-2 (FGF-2) expression of astrocytes were quantitatively evaluated in the dorsal horn of the spinal segment L4. Following inflammation, the area density of GFAP-IR as well as the proportion of astrocytes expressing FGF-2 increased significantly while the degree of astrocyte arborisation decreased as shown by a shape factor. The density of cell nuclei was unchanged suggesting that no myositis-induced cell divisions occurred. The data indicate that spinal astrocytes may influence pain processes particularly by increased FGF-2 synthesis. |
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| Item Description: | Gesehen am 01.09.2017 |
| Physical Description: | Online Resource |
| ISSN: | 1872-7972 |
| DOI: | 10.1016/j.neulet.2003.12.003 |