Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma
We recently reported a truncating deletion in the NFKBIE gene, which encodes IκBε, a negative feedback regulator of NF-κB, in clinically aggressive chronic lymphocytic leukemia (CLL). Because preliminary data indicate enrichment of NFKBIE aberrations in other lymphoid malignancies, we screened a lar...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
26 September 2016
|
| In: |
Blood
Year: 2016, Jahrgang: 128, Heft: 23, Pages: 2666-2670 |
| ISSN: | 1528-0020 |
| DOI: | 10.1182/blood-2016-03-704528 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1182/blood-2016-03-704528 Verlag, kostenfrei, Volltext: http://www.bloodjournal.org/content/128/23/2666 
|
| Verfasserangaben: | Larry Mansouri, Daniel Noerenberg, Emma Young, Elena Mylonas, Maysaa Abdulla, Mareike Frick, Fazila Asmar, Viktor Ljungström, Markus Schneider, Kenichi Yoshida, Aron Skaftason, Tatjana Pandzic, Blanca Gonzalez, Anna Tasidou, Nils Waldhueter, Alfredo Rivas-Delgado, Maria Angelopoulou, Marita Ziepert, Christopher Maximilian Arends, Lucile Couronné, Dido Lenze, Claudia D. Baldus, Christian Bastard, Jessica Okosun, Jude Fitzgibbon, Bernd Dörken, Hans G. Drexler, Damien Roos-Weil, Clemens A. Schmitt, Helga D. Munch-Petersen, Thorsten Zenz, Martin-Leo Hansmann, Jonathan C. Strefford, Gunilla Enblad, Olivier A. Bernard, Elisabeth Ralfkiaer, Martin Erlanson, Penelope Korkolopoulou, Magnus Hultdin, Theodora Papadaki, Kirsten Grønbæk, Armando Lopez-Guillermo, Seishi Ogawa, Ralf Küppers, Kostas Stamatopoulos, Niki Stavroyianni, George Kanellis, Andreas Rosenwald, Elias Campo, Rose-Marie Amini, German Ott, Theodoros P. Vassilakopoulos, Michael Hummel, Richard Rosenquist, Frederik Damm |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1563290367 | ||
| 003 | DE-627 | ||
| 005 | 20220813221927.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 170907s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1182/blood-2016-03-704528 |2 doi | |
| 035 | |a (DE-627)1563290367 | ||
| 035 | |a (DE-576)493290362 | ||
| 035 | |a (DE-599)BSZ493290362 | ||
| 035 | |a (OCoLC)1340979124 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Mansouri, Larry |e VerfasserIn |0 (DE-588)113944817X |0 (DE-627)897184092 |0 (DE-576)493285199 |4 aut | |
| 245 | 1 | 0 | |a Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma |c Larry Mansouri, Daniel Noerenberg, Emma Young, Elena Mylonas, Maysaa Abdulla, Mareike Frick, Fazila Asmar, Viktor Ljungström, Markus Schneider, Kenichi Yoshida, Aron Skaftason, Tatjana Pandzic, Blanca Gonzalez, Anna Tasidou, Nils Waldhueter, Alfredo Rivas-Delgado, Maria Angelopoulou, Marita Ziepert, Christopher Maximilian Arends, Lucile Couronné, Dido Lenze, Claudia D. Baldus, Christian Bastard, Jessica Okosun, Jude Fitzgibbon, Bernd Dörken, Hans G. Drexler, Damien Roos-Weil, Clemens A. Schmitt, Helga D. Munch-Petersen, Thorsten Zenz, Martin-Leo Hansmann, Jonathan C. Strefford, Gunilla Enblad, Olivier A. Bernard, Elisabeth Ralfkiaer, Martin Erlanson, Penelope Korkolopoulou, Magnus Hultdin, Theodora Papadaki, Kirsten Grønbæk, Armando Lopez-Guillermo, Seishi Ogawa, Ralf Küppers, Kostas Stamatopoulos, Niki Stavroyianni, George Kanellis, Andreas Rosenwald, Elias Campo, Rose-Marie Amini, German Ott, Theodoros P. Vassilakopoulos, Michael Hummel, Richard Rosenquist, Frederik Damm |
| 264 | 1 | |c 26 September 2016 | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 07.09.2017 | ||
| 520 | |a We recently reported a truncating deletion in the NFKBIE gene, which encodes IκBε, a negative feedback regulator of NF-κB, in clinically aggressive chronic lymphocytic leukemia (CLL). Because preliminary data indicate enrichment of NFKBIE aberrations in other lymphoid malignancies, we screened a large patient cohort (n = 1460) diagnosed with different lymphoid neoplasms. While NFKBIE deletions were infrequent in follicular lymphoma, splenic marginal zone lymphoma, and T-cell acute lymphoblastic leukemia (<2%), slightly higher frequencies were seen in diffuse large B-cell lymphoma, mantle cell lymphoma, and primary central nervous system lymphoma (3% to 4%). In contrast, a remarkably high frequency of NFKBIE aberrations (46/203 cases [22.7%]) was observed in primary mediastinal B-cell lymphoma (PMBL) and Hodgkin lymphoma (3/11 cases [27.3%]). NFKBIE-deleted PMBL patients were more often therapy refractory (P = .022) and displayed inferior outcome compared with wild-type patients (5-year survival, 59% vs 78%; P = .034); however, they appeared to benefit from radiotherapy (P = .022) and rituximab-containing regimens (P = .074). NFKBIE aberrations remained an independent factor in multivariate analysis (P = .003) and when restricting the analysis to immunochemotherapy-treated patients (P = .008). Whole-exome sequencing and gene expression profiling verified the importance of NF-κB deregulation in PMBL. In summary, we identify NFKBIE aberrations as a common genetic event across B-cell malignancies and highlight NFKBIE deletions as a novel poor-prognostic marker in PMBL. | ||
| 700 | 1 | |a Zenz, Thorsten |d 1970- |e VerfasserIn |0 (DE-588)114963738 |0 (DE-627)577184202 |0 (DE-576)180278266 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Blood |d Washington, DC : American Society of Hematology, 1946 |g 128(2016), 23, Seite 2666-2670 |h Online-Ressource |w (DE-627)266886647 |w (DE-600)1468538-3 |w (DE-576)075961938 |x 1528-0020 |7 nnas |a Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma |
| 773 | 1 | 8 | |g volume:128 |g year:2016 |g number:23 |g pages:2666-2670 |g extent:5 |a Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1182/blood-2016-03-704528 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://www.bloodjournal.org/content/128/23/2666 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20170907 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 114963738 |a Zenz, Thorsten |m 114963738:Zenz, Thorsten |p 31 | ||
| 999 | |a KXP-PPN1563290367 |e 2979783013 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":"26 September 2016","dateIssuedKey":"2016"}],"id":{"doi":["10.1182/blood-2016-03-704528"],"eki":["1563290367"]},"name":{"displayForm":["Larry Mansouri, Daniel Noerenberg, Emma Young, Elena Mylonas, Maysaa Abdulla, Mareike Frick, Fazila Asmar, Viktor Ljungström, Markus Schneider, Kenichi Yoshida, Aron Skaftason, Tatjana Pandzic, Blanca Gonzalez, Anna Tasidou, Nils Waldhueter, Alfredo Rivas-Delgado, Maria Angelopoulou, Marita Ziepert, Christopher Maximilian Arends, Lucile Couronné, Dido Lenze, Claudia D. Baldus, Christian Bastard, Jessica Okosun, Jude Fitzgibbon, Bernd Dörken, Hans G. Drexler, Damien Roos-Weil, Clemens A. Schmitt, Helga D. Munch-Petersen, Thorsten Zenz, Martin-Leo Hansmann, Jonathan C. Strefford, Gunilla Enblad, Olivier A. Bernard, Elisabeth Ralfkiaer, Martin Erlanson, Penelope Korkolopoulou, Magnus Hultdin, Theodora Papadaki, Kirsten Grønbæk, Armando Lopez-Guillermo, Seishi Ogawa, Ralf Küppers, Kostas Stamatopoulos, Niki Stavroyianni, George Kanellis, Andreas Rosenwald, Elias Campo, Rose-Marie Amini, German Ott, Theodoros P. Vassilakopoulos, Michael Hummel, Richard Rosenquist, Frederik Damm"]},"physDesc":[{"extent":"5 S."}],"relHost":[{"pubHistory":["1.1946 -"],"titleAlt":[{"title":"Blood online"}],"part":{"year":"2016","pages":"2666-2670","issue":"23","text":"128(2016), 23, Seite 2666-2670","volume":"128","extent":"5"},"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphomaBlood","note":["Gesehen am 21.04.2023"],"recId":"266886647","corporate":[{"role":"isb","display":"American Society of Hematology","roleDisplay":"Herausgebendes Organ"}],"language":["eng"],"title":[{"title_sort":"Blood","title":"Blood","subtitle":"journal of the American Society of Hematology"}],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisherPlace":"Washington, DC ; Philadelphia, Pa. ; Stanford, Calif.","dateIssuedDisp":"1946-","publisher":"American Society of Hematology ; Saunders ; HighWire Press","dateIssuedKey":"1946"}],"id":{"eki":["266886647"],"zdb":["1468538-3"],"issn":["1528-0020"]}}],"title":[{"title_sort":"Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma","title":"Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma"}],"person":[{"given":"Larry","family":"Mansouri","role":"aut","display":"Mansouri, Larry","roleDisplay":"VerfasserIn"},{"role":"aut","display":"Zenz, Thorsten","roleDisplay":"VerfasserIn","given":"Thorsten","family":"Zenz"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 07.09.2017"],"recId":"1563290367","language":["eng"]} | ||
| SRT | |a MANSOURILAFREQUENTNF2620 | ||