Antiapoptotic effects of propolis extract and propol on human macrophages exposed to minimally modified low density lipoprotein
An aqueous extract of propolis and the phenolic component of propolis, propol, were assayed for antioxidative and antiapoptotic properties. Both additions inhibited Cu<sup>2+</sup>-initiated low density lipoprotein (LDL) oxidation as characterized by a reduction of the lag time, reduced...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Deutsch |
| Veröffentlicht: |
2000
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| In: |
Arzneimittelforschung
Year: 2000, Jahrgang: 50, Heft: 4, Pages: 373-379 |
| ISSN: | 1616-7066 |
| DOI: | 10.1055/s-0031-1300216 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1055/s-0031-1300216 Verlag, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0031-1300216 
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| Verfasserangaben: | Ralf Claus, Ralf Kinscherf, Christof Gehrke, Gabriel Bonaterra, Purusotam Basnet, Jürgen Metz, Hans-Peter Deigner |
| Zusammenfassung: | An aqueous extract of propolis and the phenolic component of propolis, propol, were assayed for antioxidative and antiapoptotic properties. Both additions inhibited Cu<sup>2+</sup>-initiated low density lipoprotein (LDL) oxidation as characterized by a reduction of the lag time, reduced the increase of relative electrophoretic mobility during oxidation and markedly diminished apoptosis of human macrophages exposed to minimally modified (mmLDL). Moreover, aqueous propolis extract and propol blocked the mmLDL-induced decrease of glutathione (GSH) and the activation of the transcription factor NF-kB in these cells. The potent phenolic antioxidant propol thus expands the capability of cells to neutralize oxidative stress and to prevent apoptosis and is therefore suggested to significantly contribute to the antiinflammatory and antioxidative effects of propolis. |
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| Beschreibung: | Gesehen am 13.09.2017 |
| Beschreibung: | Online Resource |
| ISSN: | 1616-7066 |
| DOI: | 10.1055/s-0031-1300216 |