Safe and fast flow synthesis of functionalized oxazoles with molecular oxygen in a microstructured reactor
The synthesis of hydroperoxymethyl oxazoles by oxidation of alkylideneoxazoles with molecular oxygen was implemented in a microstructured reactor for increased safety and larger-scale applications. Elaborate studies on the influence of pressure and temperature were performed, and the apparent activa...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
June 13, 2016
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| In: |
Organic process research & development
Year: 2016, Volume: 20, Issue: 7, Pages: 1297-1304 |
| ISSN: | 1520-586X |
| DOI: | 10.1021/acs.oprd.6b00118 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1021/acs.oprd.6b00118
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| Author Notes: | Sarah Bay, Tobias Baumeister, A. Stephen K. Hashmi, and Thorsten Röder |
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| 520 | |a The synthesis of hydroperoxymethyl oxazoles by oxidation of alkylideneoxazoles with molecular oxygen was implemented in a microstructured reactor for increased safety and larger-scale applications. Elaborate studies on the influence of pressure and temperature were performed, and the apparent activation energy for the oxidation reaction was determined. Elevated temperatures up to 100 °C and pressures up to 18 bar(a) led to a conversion rate of approximately 90% within 4 h of the reaction time, thus displaying the high potential and beneficial effect of using a microreactor setup with liquid recycle loop for this oxidation. The in situ reduction of the generated hydroperoxide functionality shows the capability of this setup for follow-up transformations. | ||
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