Comparison of 68Ga-DOTATOC biodistribution in patients with and without spleenectomy
Ga-68 labeled somatostatin analogues such as 68Ga-DOTA0-Phe1-Tyr3-octrotide (DOTATOC) as PET tracers, have significantly improved the imaging of somatostatin receptors (SSTRs) expressing tumors. Due to unspecific parenchymal binding and the expression of SSTRs on leukocytes in the spleen this is the...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
March 2015
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| In: |
The quarterly journal of nuclear medicine and molecular imaging
Year: 2015, Volume: 59, Issue: 1, Pages: 116-120 |
| ISSN: | 1827-1936 |
| Online Access: | Verlag, kostenfrei, Volltext: https://www.minervamedica.it/en/journals/nuclear-med-molecular-imaging/article.php?cod=R39Y2015N01A0116
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| Author Notes: | C. Kratochwil, E. Mavriopoulou, D. Rath, A. Afshar-Oromieh, D. Apostolopoulos, S. Haufe, W. Mier, U. Haberkorn, F. L. Giesel |
| Summary: | Ga-68 labeled somatostatin analogues such as 68Ga-DOTA0-Phe1-Tyr3-octrotide (DOTATOC) as PET tracers, have significantly improved the imaging of somatostatin receptors (SSTRs) expressing tumors. Due to unspecific parenchymal binding and the expression of SSTRs on leukocytes in the spleen this is the organ with the highest non-tumor uptake of DOTATOC. Therefore, we investigated the potential changes of normal tissue distribution and tumor concentration in patients with neuroendocrine tumors (NETs) with or without spleenectomy. |
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| Item Description: | Gesehen am 25.09.2017 |
| Physical Description: | Online Resource |
| ISSN: | 1827-1936 |